Results 61 to 70 of about 139 (105)

Protozoan ALKBH8 oxygenases display both DNA repair and tRNA modification activities.

PLoS ONE, 2014
The ALKBH family of Fe(II) and 2-oxoglutarate dependent oxygenases comprises enzymes that display sequence homology to AlkB from E. coli, a DNA repair enzyme that uses an oxidative mechanism to dealkylate methyl and etheno adducts on the nucleobases ...
Daria Zdżalik, Cathrine B Vågbø, Finn Kirpekar, Erna Davydova, Alicja Puścian, Agnieszka M Maciejewska, Hans E Krokan, Arne Klungland, Barbara Tudek, Erwin van den Born, Pål Ø Falnes   +10 more
doaj   +1 more source

Current trends in single‐cell RNA sequencing applications in diabetes mellitus

FEBS Open Bio, Volume 15, Issue 11, Page 1738-1761, November 2025.
Single‐cell RNA sequencing is a powerful approach to decipher the cellular and molecular landscape at a single‐cell resolution. The rapid development of this technology has led to a wide range of applications, including the detection of cellular and molecular mechanisms and the identification and introduction of novel potential diagnostic and ...
Seyed Sajjad Zadian, Khodakaram Jahanbin, Shekoofeh Nikooei, Marzieh Rostaminejad, Arezoo Rahimi, Pedram Abdizadeh, Behnam Alipoor   +6 more
wiley   +1 more source

Association of genetic variants in m1A modification core genes and neuroblastoma risk

BMC Cancer
Neuroblastoma tightly linked with genetic abnormality. The core genes responsible for RNA N1-methyladenosine (m1A) modification are critical in tumor development. Nevertheless, few reports revealed the function of m1A modification core gene polymorphisms
Susu Jiang, Siqi Dong, Yong Li, Lei Lin, Liping Chen, Wenli Zhang, Jinhong Zhu, Xinxin Zhang, Zhonghua Yang, Jiao Zhang, Jiwen Cheng, Li Li, Haixia Zhou, Suhong Li, Wenhan Yang, Jing He, Zhenjian Zhuo   +16 more
doaj   +1 more source

Structural Analysis of the AlkB Family in Poultry

Animals
The objective of this study was to identify the AlkB family genes in poultry using bioinformatics, and to explore their molecular characteristics, evolutionary relationships, and expression patterns to clarify their potential functions in poultry.
Yuling Niu, Kan Li, Xuerong You, Yutao Wu, Xue Du, Ayong Zhao, Zhijun Wang   +6 more
doaj   +1 more source

Mendelian Randomization Analysis of Mitochondria‐Related Genes and Screening of Prognostic Genes in Colorectal Cancer

Cancer Medicine, Volume 14, Issue 13, July 2025.
ABSTRACT Background Mitochondria have been linked with inflammatory colorectal cancer (CRC) development; however, the association between mitochondria‐related genes (MRGs) and CRC remains unknown. Aims To explore the causal relationship between MRGs and CRC, screen prognostic genes, conduct drug prediction analyses, and investigate the correlations ...
Limin Zhu, Xiaowei Huang, Fan Zhang, Jinzu Yang, Zhenye Xu   +4 more
wiley   +1 more source

ALKBH3‐Mediated M1A Demethylation of METTL3 Endows Pathological Fibrosis:Interplay Between M1A and M6A RNA Methylation

Advanced Science, Volume 12, Issue 19, May 22, 2025.
RNA modification is crucial in fibrosis diseases, but the role of m1A modification remains elusive. This study reveals that ALKBH3, an m1A demethylase, drives skin fibrosis by reshaping m6A RNA modification and stabilizing COL1A1 and FN1 mRNAs through METTL3, uncovering a crosstalk between m1A and m6A methylation in pathological events.
Liying Tu, Shuchen Gu, Ruoqing Xu, En Yang, Xin Huang, Hsin Liang, Shenying Luo, Haizhou Li, Yixuan Zhao, Tao Zan   +9 more
wiley   +1 more source

Unveiling the molecular complexity of proliferative diabetic retinopathy through scRNA-seq, AlphaFold 2, and machine learning

Frontiers in Endocrinology
BackgroundProliferative diabetic retinopathy (PDR), a major cause of blindness, is characterized by complex pathogenesis. This study integrates single-cell RNA sequencing (scRNA-seq), Non-negative Matrix Factorization (NMF), machine learning, and ...
Jun Wang, Hongyan Sun, Lisha Mou, Lisha Mou, Ying Lu, Ying Lu, Zijing Wu, Zijing Wu, Zuhui Pu, Zuhui Pu, Ming-ming Yang   +10 more
doaj   +1 more source

ALKBH1 Promotes N6-methyladenine DNA Modifications in Glioblastoma [PDF]

Cancer Discovery, 2018
Abstract The DNA demethylase ALKBH1 promotes glioblastoma stem cell (GSC) growth and tumorigenesis.
openaire   +1 more source

N6-methyladenine DNA Demethylase ALKBH1 Regulates Mammalian Axon Regeneration [PDF]

Neuroscience Bulletin, 2021
Qiao Li, Cheng Qian, Harry Feng, Tyger Lin, Qingsan Zhu, Ying Huang, Feng-Quan Zhou   +6 more
openaire   +2 more sources

Novel AlkB dioxygenases--alternative models for in silico and in vivo studies.

PLoS ONE, 2012
BackgroundALKBH proteins, the homologs of Escherichia coli AlkB dioxygenase, constitute a direct, single-protein repair system, protecting cellular DNA and RNA against the cytotoxic and mutagenic activity of alkylating agents, chemicals significantly ...
Damian Mielecki, Dorota Ł Zugaj, Anna Muszewska, Jan Piwowarski, Aleksandra Chojnacka, Marcin Mielecki, Jadwiga Nieminuszczy, Marcin Grynberg, Elżbieta Grzesiuk   +8 more
doaj   +1 more source