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Physiological role of mitochondrial tRNA f5C modification by Alkbh1
Physiological role of mitochondrial tRNA f5C modification by Alkbh1学位の種別: 課程博士 審査委員会委員 : （主査）東京大学教授 武川 睦寛, 東京大学教授 飯野 雄一, 東京大学教授 津本 浩平, 東京大学教授 濡木 理, 東京大学教授 饗場 ...
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Correction to: ALKBH1 deficiency leads to loss of homeostasis in human diploid somatic cells
Protein & Cellopenaire +1 more source
N6-methyladenine demethylase ALKBH1 inhibits the differentiation of skeletal muscle [PDF]
Experimental Cell Research, 2021 DNA N6-methyladenine (N6-mA) was recently recognized as a new epigenetic modification in mammalian genome, and ALKBH1 was discovered as its demethylase. Knock-out mice studies revealed that ALKBH1 was indispensable for normal embryonic development. However, the function of ALKBH1 in myogenesis is largely unknown.
Shujuan Xie +2 more
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Demethyltransferase AlkBH1 substrate diversity and relationship to human diseases
Molecular Biology Reports, 2021AlkBH1 is a member of the AlkB superfamily which are kinds of Fe (II) and α-ketoglutarate (α-KG)-dependent dioxygenases. At present, only demethyltransferases FTO and AlkBH5 have relatively clear substrate studies among these members, the types and mechanisms of substrates catalysis of other members are not clear, especially the demethyltransferase ...
Caiyan Wang
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ALKBH1-Mediated tRNA Demethylation Regulates Translation [PDF]
Cell, 2016 tRNA is a central component of protein synthesis and the cell signaling network. One salient feature of tRNA is its heavily modified status, which can critically impact its function. Here, we show that mammalian ALKBH1 is a tRNA demethylase. It mediates the demethylation of N1-methyladenosine (m1A) in tRNAs.
Dali Han +2 more
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ALKBH1 promotes lung cancer by regulating m6A RNA demethylation
Biochemical Pharmacology, 2021Lung cancer has surpassed breast cancer as the leading cause of cancer death in females in developed countries and the leading cause of cancer death in males. Despite extensive research on lung cancer, the pathogenesis of lung cancer is not fully understood.
Zhongqiu Liu, , Yu Qi
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The stress specific impact of ALKBH1 on tRNA cleavage and tiRNA generation [PDF]
RNA Biology, 2020 Abstract tiRNAs are small non-coding RNAs produced when tRNA is cleaved under stress. tRNA methylation modifications has emerged in recent years as important regulators for tRNA structural stability and sensitivity to cleavage and tiRNA generation during stress, however, the specificity and higher regulation of such a
Kuniyasu Niizuma +2 more
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ALKBH1 is a Histone H2A Dioxygenase Involved in Neural Differentiation [PDF]
Stem Cells, 2012 AlkB homolog 1 (ALKBH1) is one of nine members of the family of mammalian AlkB homologs. Most Alkbh1(-/-) mice die during embryonic development, and survivors are characterized by defects in tissues originating from the ectodermal lineage. In this study, we show that deletion of Alkbh1 prolonged the expression of pluripotency markers in embryonic stem ...
David Lando +2 more
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DNA Repair, 2022
The apurinic/apyrimidinic (abasic, AP) site is one of the most abundant DNA lesions. Previous studies by others demonstrated that human AlkB homologue 1 (ALKBH1) catalyzes the DNA strand incision at an AP site, resulting in suicidal cross-linking of the enzyme to the 3'-DNA end.
Maria Person, Xiaoying Wei
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The apurinic/apyrimidinic (abasic, AP) site is one of the most abundant DNA lesions. Previous studies by others demonstrated that human AlkB homologue 1 (ALKBH1) catalyzes the DNA strand incision at an AP site, resulting in suicidal cross-linking of the enzyme to the 3'-DNA end.
Maria Person, Xiaoying Wei
exaly +3 more sources