Results 91 to 100 of about 139 (105)
DNA demethylase ALKBH1 promotes adipogenic differentiation via regulation of HIF-1 signaling [PDF]
Journal of Biological Chemistry, 2022 DNA N6-adenine methylation (6mA), as a novel adenine modification existing in eukaryotes, shows essential functions in embryogenesis and mitochondrial transcriptions. ALKBH1 is a demethylase of 6mA and plays critical roles in osteogenesis, tumorigenesis, and adaptation to stress.
Yuan Wang, Shuang Jiang, Yuchen Guo
exaly +3 more sources
Cell Reports, 2023 DNA N6-methyladenine (6mA) is an epigenetic modification that regulates various biological processes. Here, we show that gastric cancer (GC) cells and tumors display a marked reduction in 6mA levels compared with normal gastric tissues and cells. 6mA is abundant in the surrounding transcription start sites and occurs at consensus motifs.
Yu Jun, Hongyan Gou
exaly +3 more sources
MiRNA-339-5p suppresses the malignant development of gastric cancer via targeting ALKBH1
Experimental and Molecular Pathology, 2020 To uncover the role of microRNA-339-5p (miRNA-339-5p) in the development of gastric cancer (GC) and its possible molecular mechanism.Differential expressions of miRNA-339-5p in GC and adjacent normal tissues were detected. The relationship between miRNA-339-5p level and clinical features in GC patients was analyzed.
Jieyun Zhang
exaly +3 more sources
ALKBH1 promotes HIF-1α-mediated glycolysis by inhibiting N-glycosylation of LAMP2A
Cellular and Molecular Life SciencesAbstractALKBH1 is a typical demethylase of nucleic acids, which is correlated with multiple types of biological processes and human diseases. Recent studies are focused on the demethylation of ALKBH1, but little is known about its non-demethylase function.
Qinghua Zhou +2 more
exaly +3 more sources
Some of the next articles are maybe not open access.
Related searches:
Related searches:
MORC–ALKBH1 antagonism shapes three‐dimensional gene regulation in rice
Journal of Integrative Plant BiologyThis commentary highlights how antagonistic actions between MORC proteins and the DNA demethylase ALKBH1 shape three-dimensional chromatin organization in rice. By balancing gene silencing and activation at stress-responsive loci, this mechanism provides insights into chromatin regulation and offers potential applications for developing stress ...
Muhammad Fahad +3 more
openaire +2 more sources
Discovery of a Potent and Cell-Active Inhibitor of DNA 6mA Demethylase ALKBH1
Journal of the American Chemical SocietyN6-Methyladenine (6mA) of DNA has emerged as a novel epigenetic mark in eukaryotes, and several 6mA effector proteins have been identified. However, efforts to selectively inhibit the biological functions of these effector proteins with small molecules are unsuccessful to date. Here we report the first potent and selective small molecule inhibitor (13h)
Liang Xiong +8 more
openaire +2 more sources
Elucidating the Role of ALKBH1 in Arsenic-Induced Skin Tumorigenesis
Skin cancer is the most common form of cancer in the U.S and is commonly driven by exposure to environmental factors. A major environmental risk factor for skin cancer development is through chronic arsenic exposure. Arsenic is a metalloid that is found naturally within the Earth's crust.openaire +1 more source
Odontology
Head and neck squamous cell carcinoma (HNSCC) is an aggressive form of cancer with high metastasis rates and poor prognosis. Therefore, identifying potential biomarkers to improve prognosis and develop effective treatment is essential. ALKBH1, a member of the AlkB family of dioxygenases, has recently arisen as a potential biomarker in several types of ...
Paramasivam Arumugam +2 more
openaire +2 more sources
Head and neck squamous cell carcinoma (HNSCC) is an aggressive form of cancer with high metastasis rates and poor prognosis. Therefore, identifying potential biomarkers to improve prognosis and develop effective treatment is essential. ALKBH1, a member of the AlkB family of dioxygenases, has recently arisen as a potential biomarker in several types of ...
Paramasivam Arumugam +2 more
openaire +2 more sources