Results 71 to 80 of about 139 (105)

ALKBH1 rs2267755 C>T polymorphism decreases neuroblastoma risk in Chinese children

Journal of Cancer
Neuroblastoma is a highly malignant extracranial solid tumor in pediatrics. ALKBH1 as a recently discovered DNA N6-methyldeoxyadenosine (6mA) demethylase closely links to tumorigenesis. Whether the ALKBH1 polymorphism contributes to neuroblastoma risk remains unclear.
Zhang, Xinxin, Zhou, Chunlei, Zhao, Yemu, Deng, Changmi, Wu, Haiyan, Zhuo, Zhenjian, He, Jing   +6 more
openaire   +2 more sources

ALKBH1-mediated N6-methyladenosine methylation of TRAF1 promotes osteosarcoma proliferation and metastasis

American Journal of Cancer Research
Osteosarcoma (OS) is a highly malignant bone tumor with poor prognosis and limited therapeutic options. Recent studies have highlighted the critical role of RNA modifications, particularly N6-methyladenosine (m6A) methylation, in cancer progression.
Zhichao, Wang, Yuli, Fang, Yang, Yu, Haile, Pan   +3 more
openaire   +2 more sources

Publication Only

HemaSphere, Volume 10, Issue S1, June 2026.
wiley   +1 more source

Structural basis of nucleic acid recognition and 6mA demethylation by human ALKBH1 [PDF]

Cell Research, 2020
Li-Fei Tian, Yan-Ping Liu, Lianqi Chen, Qun Tang, Wei Wu, Wei Sun, Zhongzhou Chen, Xiao-Xue Yan   +7 more
openaire   +2 more sources

m¹A and m⁶A RNA Methylations as Druggable Targets in Cancer

Pharmaceuticals
Epitranscriptomic modifications, particularly RNA methylations, have emerged as regulators of gene expression, with their dysregulation acting as a key factor in tumorigenesis and metastatic progression.
Yasemin Gazaloğlu, Buket Sağlam-Şen, Bünyamin Akgül   +2 more
doaj   +1 more source

Research progress of N1-methyladenosine RNA modification in cancer

Cell Communication and Signaling
N1-methyladenosine (m1A) is a post-transcriptionally modified RNA molecule that plays a pivotal role in the regulation of various biological functions and activities. Especially in cancer cell invasion, proliferation and cell cycle regulation.
Yafeng Liu, Shujun Zhang, Xiaohui Gao, Yi Ru, Xinyu Gu, Xinjun Hu   +5 more
doaj   +1 more source

Depletion of the m1A writer TRMT6/TRMT61A reduces proliferation and resistance against cellular stress in bladder cancer

Frontiers in Oncology
BackgroundBladder cancer (BLCA) is a common and deadly disease that results in a reduced quality of life for the patients and a significant economic burden on society. A better understanding of tumorigenesis is needed to improve clinical outcomes. Recent
Ida Monshaugen, Ida Monshaugen, Ida Monshaugen, Luisa Luna, Jayden Rhodes, Felicia Iselin Svensson Kristiansen, Felicia Iselin Svensson Kristiansen, Felicia Iselin Svensson Kristiansen, Anna Lång, Stig Ove Bøe, Anindya Dutta, Zhangli Su, Arne Klungland, Arne Klungland, Rune Ougland, Rune Ougland   +15 more
doaj   +1 more source

A novel disulfidptosis-related mRNA signature predicts prognosis and therapeutic response in lung squamous cell carcinoma

BMC Pulmonary Medicine
Background Lung squamous cell carcinoma (LUSC) remains an aggressive malignancy with limited therapeutic options and poor prognosis. Recent studies have identified disulfidptosis as a novel form of metabolic stress-induced cell death, but its clinical ...
Wei Bai, Ning Jiang, Yuhan Deng, Xiaofeng Tang, Feifei Zhang, Shaorui Niu, Yuyang Yao, Yuhao Zhou, Kangming Chen, Liping Li, Jun Yang, Xiao-Bin Lv   +11 more
doaj   +1 more source

ALKBH1 Drives Tumorigenesis and Drug Resistance via tRNA-decoding Reprogramming and Codon-biased Translation

Cancer Discovery
Abstract Cancer cells utilize codon-biased translation to fuel tumorigenesis and drug resistance; however, underlying mechanisms remain poorly understood. In this study, we show that ALKBH1 is overexpressed in acute myeloid leukemia (AML) and essential for leukemia stem cell/leukemia ...
Chao Shen, Yuan Che, Keren Zhou, Kitty Wang, Wei Li, Diyuan Xue, Tong Wu, Lu Yang, Meiling Chen, Yue Sheng, Chengwan Zhang, Sean Robinson, Huiying Chen, Lillian Sau, Zhenhua Chen, Mark Wunderlich, Li Han, Tingting Tang, Ying Qing, Dong Wu, Miao Sun, Keith Leung, Katarzyna Dąbrowska, Patrick Pirrotte, Yueh-Chiang Hu, Lucy Y. Ghoda, Bin Zhang, James C. Mulloy, Minjie Wei, Guido Marcucci, Chuan He, Xiaolan Deng, Jianjun Chen   +32 more
openaire   +3 more sources

In vivo characterization of the mammalian AlkB homologues ALKBH1 and ALKBH4

, 2014
The E.coli DNA repair enzyme AlkB acts by hydroxylating methyl lesions in DNA, such as 1-methylAdenine (1meA) and 3-methylCytosine (3meC), which leads to spontaneous loss of the hydroxymethyl group and recovery of the correct base. Nine different mammalian AlkB homologues have been identified.
openaire   +4 more sources