Results 51 to 60 of about 139 (105)

MicroRNA-3935 promotes human trophoblast cell epithelial-mesenchymal transition through tumor necrosis factor receptor-associated factor 6/regulator of G protein signaling 2 axis

Reproductive Biology and Endocrinology, 2021
Background Insufficient migration and invasion during trophoblast epithelial-mesenchymal transition (EMT) results in the occurrence and development of preeclampsia (PE), and our previous study has screened 52 miRNAs, whose expression levels are altered ...
Meiyuan Jin, Shouying Xu, Jiayong Li, Yingyu Yao, Chao Tang   +4 more
doaj   +1 more source

The 5‐Methylcytosine RNA Modification in Hepatitis B Virus‐Negative Hepatocellular Carcinoma: Insights From Long‐Read Nanopore Sequencing

Molecular Carcinogenesis, Volume 65, Issue 4, Page 397-406, April 2026.
ABSTRACT 5‐Methylcytosine (m5C) RNA modification contributes to tumor initiation and progression. However, its transcriptome‐wide distribution patterns and biological implications in hepatitis B virus (HBV)‐negative hepatocellular carcinoma (HCC) remain poorly understood.
Tianhan Sun, Liying Zhou, XiaoQing Li, Ryan Xiao, Gaoyuan Sun, Lili Zhang, Yifei Li, Wei Huang, Yayu Li, Lu Kuai, Xuanmei Luo, Hongyuan Cui, Meng Chen   +12 more
wiley   +1 more source

A DNA‐Based Binding Assay for the m6A‐RNA Reader Proteins

ChemBioChem, Volume 27, Issue 6, 27 March 2026.
We report the structure of the m6A‐RNA reader YTHDC2 in the complex with single‐stranded DNA. We provide evidence that the readers exhibit slightly stronger affinity for 6mA‐modified DNA than RNA. Thus, we developed an FP binding assay that uses single‐stranded DNA as probe.
Rajiv Kumar Bedi, Amedeo Caflisch
wiley   +1 more source

Extracellular matrix stiffness reduces DNA 6 ma level to facilitate colorectal cancer progression via disrupting P53 binding to CDKN1A promoter

Experimental Hematology & Oncology
The extracellular matrix (ECM) forms the primary scaffold of the tumor microenvironment, with matrix stiffness serving as a critical physical cue that modulates cancer progression.
Si-An Xie, Xue Li, Min-Yue Yin, Feng Du, Shu-Tian Zhang, Sheng-Tao Zhu   +5 more
doaj   +1 more source

Niraparib promotes ferroptosis by inhibiting TM4SF1 expression through ALKBH1-mediated 6mA modification in BRCA wild-type ovarian cancer

Frontiers in Pharmacology
ObjectiveNiraparib significantly improves the prognosis of patients with BRCA wild-type ovarian cancer (BRCAwt OC). However, the underlying mechanisms remain elusive.
Po-Wu Liu, Po-Wu Liu, Zhao-Yi Liu, Nayiyuan Wu, Xiu Zhang, Jia-Jia Sheng, Sheng-An Zheng, He Li, He Li   +8 more
doaj   +1 more source

Predicting response of immunotherapy and targeted therapy and prognosis characteristics for renal clear cell carcinoma based on m1A methylation regulators

Scientific Reports, 2023
In recent years, RNA methylation modification has been found to be related to a variety of tumor mechanisms, such as rectal cancer. Clear cell renal cell carcinoma (ccRCC) is most common in renal cell carcinoma.
Lei Li, Hongwei Tan, Jiexue Zhou, Fengming Hu   +3 more
doaj   +1 more source

RNA Regulatory Networks: Key Hubs in the Panorama of Cancer and Emerging Therapeutic Targets

MedComm, Volume 7, Issue 3, March 2026.
RNA regulatory networks play a crucial role in the initiation and progression of cancer through various modes of RNA interactions. Notably, circulating RNAs have emerged as potential biomarkers, while targeted interventions in RNA regulatory networks facilitate precise therapeutic strategies. ABSTRACT Cancer is a global health challenge. The initiation
Xuan Yin, Zengkan Du, Shuya Jiang, Yan Liao, Changli Wang, Jiaqi Li, Haoling Zhang, Ting‐Ting Wei, Wangzheqi Zhang, Zui Zou   +9 more
wiley   +1 more source

The Host Coral Bleaching Response Viewed Through the Lens of Multi‐Omics

BioEssays, Volume 48, Issue 1, January 2026.
Coral bleaching is driven by multiple inputs, with heat stress and/or high irradiance being most important. The bleaching response is multifactorial with host animal species/strain and algal symbiont genotypes being critical features. Omics readout of heat stress responses includes gene expression, proteomics, metabolite, and SNP data with transcript ...
Debashish Bhattacharya, Shrinivas Nandi, Erin E. Chille, Miriam Arroyo, Timothy G. Stephens   +4 more
wiley   +1 more source

RNA m1A methyltransferase TRMT61A promotes colorectal tumorigenesis by enhancing ONECUT2 mRNA stability and is a potential therapeutic target

Cancer Communications, Volume 45, Issue 12, Page 1616-1644, December 2025.
Abstract Background The role of N1‐methyladenosine (m1A) in cancer is poorly understood. Here we explored the function of RNA methyltransferase TRNA methyltransferase 61A (TRMT61A) in colorectal cancer (CRC) and its potential as a therapeutic target. Methods RNA m1A levels were assessed through liquid chromatography‐mass spectrometry.
Xiaoting Zhang, Na Qin, Fenfen Ji, Hao Su, Haiyun Shang, Hongyan Chen, Dan Huang, Qing Li, Jing Ren, Weixin Liu, Yifei Wang, Wei Kang, Jiabin Wu, Chi‐Chun Wong, Zongwei Cai, Matthew Tak Vai Chan, William Ka Kei Wu, Jun Yu, Huarong Chen   +18 more
wiley   +1 more source

5-Formylcytosine is not a prevalent RNA modification in mammalian cells

Nature Communications
The RNA modification 5-formylcytidine (f5C) is poorly explored in mammals. Low f5C levels reported in mRNA may reflect spurious 5-methylcytidine (m5C) oxidation or targeted demethylation by TET or ALKBH1 dioxygenases.
Jasmin A. Dehnen, Alexander V. Gopanenko, Carola Scholz, Michael U. Musheev, Christof Niehrs   +4 more
doaj   +1 more source