Results 1 to 10 of about 1,629,436 (316)

Latent herpes simplex virus type 1 reactivation increases the susceptibility of neurodegenerative diseases: intervention with traditional Chinese medicine

Acta Materia Medica, 2022
Owing to environmental and lifestyle changes in modern society, physical and mental stress is on the rise among the population in attempting to compensate for the changes.
Jie Sun, Chang-Yu Yan, Jie Niu, Ming-Hai Pan, Zhuo Luo, Wen-Jun Duan, Wen Li, Yan-Ping Wu, Wan-Yang Sun, Feng Huang, Fan-Na Liu, Hai-Zhi Liu, Hiroshi Kurihara, Yi-Fang Li, Rong-Rong He   +14 more
doaj   +1 more source

The role of caspase-1, caspase-4 and NLRP3 in regulating the host cell response evoked by uropathogenic Escherichia coli

Scientific Reports, 2022
The inflammasome-associated proteins caspase-1, caspase-4 and NLRP3 have been emphasised to be essential in the host cell response during urinary tract infection (UTI) by regulating IL-1β release.
Anna Lindblad, Charlotte Johansson, Katarina Persson, Isak Demirel   +3 more
doaj   +1 more source

ALOX15-launched PUFA-phospholipids peroxidation increases the susceptibility of ferroptosis in ischemia-induced myocardial damage

Signal Transduction and Targeted Therapy, 2022
Myocardial ischemia/reperfusion (I/R) injury is a classic type of cardiovascular disease characterized by injury to cardiomyocytes leading to various forms of cell death.
Xiao-Hui Ma, Jiang-Han-Zi Liu, Chun-Yu Liu, Wan-Yang Sun, Wen-Jun Duan, Guan Wang, Hiroshi Kurihara, Rong-Rong He, Yi-Fang Li, Yang Chen, Hongcai Shang   +10 more
doaj   +1 more source

Roles of the Endogenous Lunapark Protein during Flavivirus Replication

Viruses, 2021
The endoplasmic reticulum (ER) of eukaryotic cells is a dynamic organelle, which undergoes continuous remodeling. At the three-way tubular junctions of the ER, the lunapark (LNP) protein acts as a membrane remodeling factor to stabilize these highly ...
Pham-Tue-Hung Tran, Naveed Asghar, Magnus Johansson, Wessam Melik   +3 more
doaj   +1 more source

Transcriptional alterations in bladder epithelial cells in response to infection with different morphological states of uropathogenic Escherichia coli

Scientific Reports, 2022
Uropathogenic Escherichia coli (UPEC) may undergo a cyclic cascade of morphological alterations that are believed to enhance the potential of UPEC to evade host responses and re-infect host cell.
Katarina Persson, Ulrika Petersson, Charlotte Johansson, Isak Demirel, Robert Kruse   +4 more
doaj   +1 more source

4-Allyl-2-methoxyphenol modulates the expression of genes involved in efflux pump, biofilm formation and sterol biosynthesis in azole resistant Aspergillus fumigatus

Frontiers in Cellular and Infection Microbiology, 2023
IntroductionAntifungal therapy for aspergillosis is becoming problematic because of the toxicity of currently available drugs, biofilm formation on host surface, and increasing prevalence of azole resistance in Aspergillus fumigatus.
Pooja Sen, Lovely Gupta, Mukund Vijay, Maansi Vermani Sarin, Jata Shankar, Saif Hameed, Pooja Vijayaraghavan   +6 more
doaj   +1 more source

Gene expression, molecular docking, and molecular dynamics studies to identify potential antifungal compounds targeting virulence proteins/genes VelB and THR as possible drug targets against Curvularia lunata

Frontiers in Molecular Biosciences, 2022
Curvuluria lunata is a melanized fungus pathogenic to both plants and animals including humans, causing from mild, febrile to life-threatening illness if not well treated.
Himanshu Kamboj, Lovely Gupta, Pawan Kumar, Pooja Sen, Abhishek Sengupta, Pooja Vijayaraghavan   +5 more
doaj   +1 more source

Activation of NLRP3 by uropathogenic Escherichia coli is associated with IL-1β release and regulation of antimicrobial properties in human neutrophils

Scientific Reports, 2020
The NLRP3 inflammasome and IL-1β have recently been linked to the severity of uropathogenic Escherichia coli (UPEC)-mediated urinary tract infection (UTI).
Isak Demirel, Alexander Persson, Annelie Brauner, Eva Särndahl, Robert Kruse, Katarina Persson   +5 more
doaj   +1 more source

Potential of Tamarind Shell Extract against Oxidative Stress In Vivo and In Vitro

Molecules, 2023
Tamarind shell is rich in flavonoids and exhibits good biological activities. In this study, we aimed to analyze the chemical composition of tamarind shell extract (TSE), and to investigate antioxidant capacity of TSE in vitro and in vivo.
Weixi Li, Rongping Huang, Shaocong Han, Xiyou Li, Haibiao Gong, Qiongyi Zhang, Changyu Yan, Yifang Li, Rongrong He   +8 more
doaj   +1 more source

Circulating tumour-derived KRAS mutations in pancreatic cancer cases are predominantly carried by very short fragments of cell-free DNA

EBioMedicine, 2020
Background: The DNA released into the bloodstream by malignant tumours· called circulating tumour DNA (ctDNA), is often a small fraction of total cell-free DNA shed predominantly by hematopoietic cells and is therefore challenging to detect ...
Maria Zvereva, Gabriel Roberti, Geoffroy Durand, Catherine Voegele, Minh Dao Nguyen, Tiffany M. Delhomme, Priscilia Chopard, Eleonora Fabianova, Zora Adamcakova, Ivana Holcatova, Lenka Foretova, Vladimir Janout, Paul Brennan, Matthieu Foll, Graham B. Byrnes, James D. McKay, Ghislaine Scelo, Florence Le Calvez-Kelm   +17 more
doaj   +1 more source