PTPN2 gene variants are associated with susceptibility to both Crohn's disease and ulcerative colitis supporting a common genetic disease background. [PDF]
Genome-wide association studies identified PTPN2 (protein tyrosine phosphatase, non-receptor type 2) as susceptibility gene for inflammatory bowel diseases (IBD).
Darina Czamara +63 more
core +1 more source
Loss of RASGRP1 in humans impairs T‐cell expansion leading to Epstein‐Barr virus susceptibility
Inherited CTPS1, CD27, and CD70 deficiencies in humans have revealed key factors of T‐lymphocyte expansion, a critical prerequisite for an efficient immunity to Epstein–Barr virus (EBV) infection.
Sarah Winter +9 more
doaj +1 more source
Antifungal Resistance Analysis of Environmental Isolates of Aspergillus in North India
Triazoles are the major group of antifungals for treating Aspergillus infections. The morbidity and mortality associated with these infections is high and rate of treatment failure is more in patients infected with azole resistant Aspergillus.
Shanu Hoda +4 more
doaj +1 more source
Revealing new tick-borne encephalitis virus foci by screening antibodies in sheep milk
Background Tick distribution in Sweden has increased in recent years, with the prevalence of ticks predicted to spread towards the northern parts of the country, thus increasing the risk of tick-borne zoonoses in new regions. Tick-borne encephalitis (TBE)
Amélie Wallenhammar +8 more
doaj +1 more source
Acute hypotension is a common complication of haemodialysis, occurring in 20-33% of patients in different series. Although the immediate cause is increasing intravascular hypovolaemia related to the dialysis procedure, no constant relationship exists between volume status or degree of volume loss and development of hypotension, emphasizing the ...
openaire +2 more sources
Autocorrelation of the susceptible-infected-susceptible process on networks [PDF]
In this paper, we focus on the autocorrelation of the susceptible-infected-susceptible (SIS) process on networks. The N-intertwined mean-field approximation (NIMFA) is applied to calculate the autocorrelation properties of the exact SIS process. We derive the autocorrelation of the infection state of each node and the fraction of infected nodes both in
Liu, Q. (author) +1 more
openaire +4 more sources
Species Distribution and in Vitro Antifungal Susceptibility of Oral Yeast Isolates from Tanzanian HIV-Infected Patients With Primary and Recurrent Oropharyngeal Candidiasis. [PDF]
\ud In Tanzania, little is known on the species distribution and antifungal susceptibility profiles of yeast isolates from HIV-infected patients with primary and recurrent oropharyngeal candidiasis.
Rijs Antonius JMM +51 more
core +1 more source
Clinical limitations and drug-resistance are the basis of the search for new antifungal therapeutics against biofilm forming pathogen Aspergillus fumigatus.
Shanu Hoda +5 more
doaj +1 more source
Why only 20% of smokers develop clinically relevant chronic obstructive pulmonary disease (COPD) was a puzzle for many years. Now, epidemiologic studies point clearly toward a large heritable component. The combination of genome-wide association studies and candidate gene analysis is helping to identify those genetic variants responsible for an ...
Marciniak, Stefan J, Lomas, David A
openaire +3 more sources
TERC polymorphisms are associated both with susceptibility to colorectal cancer and with longer telomeres. [PDF]
Shorter telomeres have been associated with increased risk of malignancy, including colorectal cancer (CRC). Telomere length is heritable and may be an intermediate phenotype linked to genetic susceptibility to ...
Tomlinson, IP +63 more
core +1 more source

