Results 21 to 30 of about 139 (105)
ALKBH1 reduces DNA N6-methyladenine to allow for vascular calcification in chronic kidney disease [PDF]
Journal of Clinical Investigation, 2021 Vascular calcification is a common complication of chronic kidney disease (CKD), and one of the main risk factors for increased cardiovascular morbidity and mortality in patients with CKD. In this issue of the JCI, Ouyang and Su et al. report that Alkb homolog 1 (ALKBH1), a DNA demethylase, reduced DNA N6-methyladenine (6mA) in vascular smooth muscle ...
Ke, Zhu, Jochen, Reiser
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Journal of Fungi, 2021 The epigenetic modifications control the pathogenicity of human pathogenic fungi, which have been poorly studied in Mucorales, causative agents of mucormycosis.
Macario Osorio-Concepción +4 more
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Reactivity-dependent profiling of RNA 5-methylcytidine dioxygenases
Nature Communications, 2022 Kleiner and co-workers profile RNA 5-methylcytidine (m5C) dioxygenase enzymes using an activity-based metabolic probing strategy. They reveal ALKBH1 as the major 5-formylcytidine (f5C) writer and characterize modification sites across mRNA and tRNA.
A. Emilia Arguello +5 more
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DNA, 2023 Nucleic acid methylations are important genetic and epigenetic biomarkers. The formation and removal of these markers is related to either methylation or demethylation.
Zhiyuan Peng +5 more
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Frontiers in Genetics, 2021 Alpha-ketoglutarate-dependent dioxygenase (ALKBH) is a DNA repair gene involved in the repair of alkylating DNA damage. There are nine types of ALKBH (ALKBH1-8 and FTO) identified in humans.
Shengyuan Zhao +3 more
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Impaired placental trophoblast lineage differentiation in Alkbh1−/− mice [PDF]
Developmental Dynamics, 2008 AbstractE. coli AlkB has been intensively studied since 1983, but the in vivo roles of its mammalian homologue Alkbh1 are unknown. We, therefore, created null mice for Alkbh1. Alkbh1 mRNA is expressed at highest levels in the trophoblast lineages of the developing placenta.
Zishu, Pan +8 more
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Ablation of the miR-465 Cluster Causes a Skewed Sex Ratio in Mice
Frontiers in Endocrinology, 2022 The X-linked miR-465 cluster is highly expressed in the testis, sperm, newborn ovary, and blastocysts as well as in 8-16 cell embryos. However, the physiological role of the miR-465 cluster is still largely unknown. This study aims to dissect the role of
Zhuqing Wang +19 more
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Expression of Demethylase Genes, FTO and ALKBH1, Is Associated with Prognosis of Gastric Cancer [PDF]
Digestive Diseases and Sciences, 2019 Reversible N6-methyladenosine (m6A) modifications in messenger RNAs can be categorized under the field of "RNA epigenetics." However, the potential role of m6A-related genes in gastric cancer (GC) prognosis has not been systematically researched.This study was aimed at providing insights into the prognostic role of m6A-related gene expression, at both ...
Li, Yue +5 more
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Alkbh1 and Tzfp repress a non-repeat piRNA cluster in pachytene spermatocytes [PDF]
Nucleic Acids Research, 2012 Piwi proteins and Piwi-interacting small RNAs (piRNAs) have known functions in transposon silencing in the male germline of fetal and newborn mice. Both are also present in adult testes; however, their function here remains a mystery. Here, we confirm that most piRNAs in meiotic spermatocytes originate from clusters in non-repeat intergenic regions of ...
Nordstrand, Line Mari +4 more
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The role of demethylase AlkB homologs in cancer
Frontiers in Oncology, 2023 The AlkB family (ALKBH1-8 and FTO), a member of the Fe (II)- and α-ketoglutarate-dependent dioxygenase superfamily, has shown the ability to catalyze the demethylation of a variety of substrates, including DNA, RNA, and histones.
Qiao Li, Qiao Li, Qingsan Zhu
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