Results 11 to 20 of about 139 (105)

Role of ALKBH1 in the Core Transcriptional Network of Embryonic Stem Cells

Cellular Physiology and Biochemistry, 2016
Background/Aims: ALKBH1, an AlkB homologue in the 2-oxoglutarate and Fe2+ dependent hydroxylase family, is a histone dioxygenase that removes methyl groups from histone H2A. Studies of transgenic mice lacking Alkbh1 reveal that most Alkbh1-/- embryos die
Rune Ougland, Ida Jonson, Marivi Nabong Moen, Gaute Nesse, Gry Asker, Arne Klungland, Elisabeth Larsen   +6 more
doaj   +3 more sources

Arsenic regulates ALKBH1 abundance and substrate specificity to promote translation and tumorigenicity

Cell Reports
Summary: The mechanisms that underlie arsenic tumorigenicity remain incompletely understood. Here, we show that arsenic regulates the abundance and the demethylase activity of ALKBH1, which, in turn, promotes arsenic-induced skin tumorigenesis.
Emma Wilkinson, Yan-Hong Cui, Zizhao Yang, Michelle Verghese, Seungwon Yang, Ming Sun, Houxiang Zhu, Jack Peterson, Jiangbo Wei, Yingming Zhao, Mengjie Chen, Chuan He, Yu-Ying He   +12 more
doaj   +4 more sources

Gene Polymorphisms of m6A Erasers FTO and ALKBH1 Associated with Susceptibility to Gastric Cancer

Pharmacogenomics and Personalized Medicine, 2022
Yue Li,* Dalei Zhou,* Qing Liu, Weijie Zhu, Zulu Ye, Caiyun He Department of Molecular Diagnostics, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine ...
Li Y, Zhou D, Liu Q, Zhu W, Ye Z, He C
doaj   +3 more sources

ALKBH1 gene polymorphisms confer hepatoblastoma susceptibility in Chinese children

Scientific Reports
Hepatoblastoma is the most common malignant liver tumor of embryonic origin in children; however, its underlying etiology remains unclear. N1-methyladenosine (m1A) modification is widely found in various human tissues and has been demonstrated to ...
Chongwei He, Lingling Pan, Xinhao Zeng, Hua Wang, Zhonghua Yang, Jiao Zhang, Yong Li, Li Li, Suhong Li, Jiwen Cheng, Yalan Song, Jing He, Chaoyang Chen   +12 more
doaj   +3 more sources

ALKBH1 activity in vitro and human cell lines by isotope dilution mass spectrometry.

PLoS ONE
AlkB homolog 1 (ALKBH1) is a member of the AlkB family of Fe(II) and α-ketoglutarate (α-KG)-dependent dioxygenases, known for its enzymatic activity on various nucleic acid substrates.
Bennett Henzeler, Olga Hofmeister, Ken Kögel, Yuyang Qi, Felix Hagelskamp, Matthias Heiß, Florian Schelter, Felix Xu, Lena J Daumann, Thomas Carell, Stefanie Kaiser, Sabine Schneider   +11 more
doaj   +3 more sources

Spatial and single-cell analyses uncover links between ALKBH1 and tumor-associated macrophages in gastric cancer

Cancer Cell International
Background AlkB homolog 1, histone H2A dioxygenase (ALKBH1), a crucial enzyme involved in RNA demethylation in humans, plays a significant role in various cellular processes.
Renin Chang, Kuan-Hao Tsui, Li-Fei Pan, Chia-Jung Li   +3 more
doaj   +3 more sources

YTHDF3 recognizes DNA N6-methyladenine and recruits ALKBH1 for 6mA removal from genomic DNA

The EMBO Journal
DNA N6-methyladenine (6mA) is an emerging epigenetic mark in the mammalian genome. ALKBH1 preferentially exhibits 6mA demethylase activity for single-stranded DNA (ssDNA) or bubbled/bulged DNA, but not for double-stranded DNA (dsDNA).
Xin-Hui Chen, Zi-Lu Wang, Jincui Yang, Min Chen, Si-Yi Zhao, Kun-Xiong Guo, Xuelong Zheng, Zhengwei Zhao, Xiaoqiang Chen, Jing Li, Min-Min Zhang, Ling Ran, Huifang Zhu, Xiao-Feng Gu, Guang-Rong Yan   +14 more
doaj   +3 more sources

ALKBH1 Gene rs6494 T>A Polymorphism Decreases Wilms Tumour Risk in Chinese Children

Journal of Cellular and Molecular Medicine, Volume 29, Issue 18, September 2025.
ABSTRACT Wilms tumour (WT) is the most predominant renal carcinoma that affects children, and the understanding of the genetic mechanisms underlying WT development is continually evolving. The role of the demethylase ALKBH1, which is known for its association with diverse cancers, in WT has never been explored.
Changmi Deng, Haixia Zhou, Na Zhang, Min Chen, Rui‐Xi Hua, Jiwen Cheng, Suhong Li, Jiao Zhang, Jichen Ruan, Wen Fu, Jing He, Guochang Liu   +11 more
wiley   +3 more sources

ALKBH1 deficiency leads to loss of homeostasis in human diploid somatic cells [PDF]

Protein & Cell, 2020
Hongyu Li, Zeming Wu, Xiaoqian Liu, Sheng Zhang, Qianzhao Ji, Xiaoyu Jiang, Zunpeng Liu, Si Wang, Jing Qu, Weiqi Zhang, Moshi Song, Eli Song, Guang-Hui Liu   +12 more
doaj   +3 more sources

ALKBH1 is an RNA dioxygenase responsible for cytoplasmic and mitochondrial tRNA modifications [PDF]

Nucleic Acids Research, 2017
ALKBH1 is a 2-oxoglutarate- and Fe2+-dependent dioxygenase responsible for multiple cellular functions. Here, we show that ALKBH1 is involved in biogenesis of 5-hydroxymethyl-2΄-O-methylcytidine (hm5Cm) and 5-formyl-2΄-O-methylcytidine (f5Cm) at the first position (position 34) of anticodon in cytoplasmic tRNALeu, as well as f5C at the same position in
Kawarada, Layla, Suzuki, Takeo, Ohira, Takayuki, Hirata, Shoji, Miyauchi, Kenjyo, Suzuki, Tsutomu   +5 more
openaire   +2 more sources