Results 1 to 10 of about 505 (67)

TRADES: Targeted RNA Demethylation by SunTag System

Advanced Science, 2020
N6‐methyladenosine (m6A) is rapidly being studied and uncovered to play a significant role in various biological processes as well as in RNA fate and functions, while the effects of defined m6A sites are rarely characterized for the lack of convenient ...
Jing Mo, Zonggui Chen, Shanshan Qin, Shu Li, Chuangang Liu, Lu Zhang, Ruoxi Ran, Ying Kong, Fang Wang, Songmei Liu, Yu Zhou, Xiaolian Zhang, Xiaocheng Weng, Xiang Zhou   +13 more
doaj   +2 more sources

Early recruitment of PARP-dependent m8A RNA methylation at DNA lesions is subsequently accompanied by active DNA demethylation

RNA Biology, 2022
RNA methylation, especially 6-methyladenosine (m6A)-modified RNAs, plays a specific role in DNA damage response (DDR). Here, we also observe that RNA modified at 8-methyladenosine (m8A) is recruited to UVA-damaged chromatin immediately after ...
Soňa Legartová, Alena Svobodová Kovaříková, Jana Běhalová Suchánková, Hana Polášek-Sedláčková, Eva Bártová   +4 more
doaj   +2 more sources

Structure and function of dioxygenases in histone demethylation and DNA/RNA demethylation

IUCrJ, 2014
Iron(II) and 2-oxoglutarate (2OG)-dependent dioxygenases involved in histone and DNA/RNA demethylation convert the cosubstrate 2OG and oxygen to succinate and carbon dioxide, resulting in hydroxylation of the methyl group of the substrates and subsequent
Cheng Dong, Heng Zhang, Chao Xu, Cheryl H. Arrowsmith, Jinrong Min   +4 more
doaj   +3 more sources

Oxidative intermediates captured during demethylation of DNA and RNA [PDF]

E3S Web of Conferences, 2021
DNA and RNA have various methylation modifications or damage that are directly related to some human diseases and physiological regulation. Most of these methylation modifications are reversible and can be dynamically repaired by RNA or DNA demethylases.
Wang Ying, Zhang Jianyu
doaj   +1 more source

The role of demethylase AlkB homologs in cancer

Frontiers in Oncology, 2023
The AlkB family (ALKBH1-8 and FTO), a member of the Fe (II)- and α-ketoglutarate-dependent dioxygenase superfamily, has shown the ability to catalyze the demethylation of a variety of substrates, including DNA, RNA, and histones.
Qiao Li, Qiao Li, Qingsan Zhu
doaj   +1 more source

Recent developments in the significant effect of mRNA modification (M6A) in glioblastoma and esophageal cancer

Scientific African, 2022
Over the years, there have been studies on the significant impact of epigenetic activities that impact the downstream effect of gene expression. Amongst these is the chemical modification of RNA which consists of over 100 types of RNA modifications ...
Alfred Olaoluwa Akinlalu, Prisca Chinonso Njoku, Chisom Vivian Nzekwe, Rukayat Olayemi Oni, Toyosi Fojude, Akinwale John Faniyi, Abolaji Samson Olagunju   +6 more
doaj   +1 more source

Methylation-sensitive expression of a DNA demethylase gene serves as an epigenetic rheostat. [PDF]

PLoS Genetics, 2015
Genomes must balance active suppression of transposable elements (TEs) with the need to maintain gene expression. In Arabidopsis, euchromatic TEs are targeted by RNA-directed DNA methylation (RdDM).
Ben P Williams, Daniela Pignatta, Steven Henikoff, Mary Gehring   +3 more
doaj   +1 more source

Tet Proteins Regulate Neutrophil Granulation in Zebrafish through Demethylation of socs3b mRNA

Cell Reports, 2021
Summary: Tet proteins (Tet1/2/3) convert 5-methylcytosine (5mC) to 5-hydroxy-methylcytosine (5hmC), initiating the process of active demethylation to regulate gene expression.
Kelly M. Banks, Yahui Lan, Todd Evans
doaj   +1 more source

A viral guide RNA delivery system for CRISPR-based transcriptional activation and heritable targeted DNA demethylation in Arabidopsis thaliana.

PLoS Genetics, 2020
Plant RNA viruses are used as delivery vectors for their high level of accumulation and efficient spread during virus multiplication and movement. Utilizing this concept, several viral-based guide RNA delivery platforms for CRISPR-Cas9 genome editing ...
Basudev Ghoshal, Brandon Vong, Colette L Picard, Suhua Feng, Janet M Tam, Steven E Jacobsen   +5 more
doaj   +1 more source

Oxidative Stress Regulates a Pivotal Metabolic Switch in Dimethylsulfoniopropionate Degradation by the Marine Bacterium Ruegeria pomeroyi

Microbiology Spectrum, 2022
Dimethylsulfoniopropionate (DMSP) is an abundant organic compound in marine surface water and source of dimethyl sulfide (DMS), the largest natural sulfur source to the upper atmosphere.
Tao Wang, Qiuyuan Huang, Andrew S. Burns, Mary Ann Moran, William B. Whitman   +4 more
doaj   +1 more source