Results 1 to 10 of about 26,295 (268)

Screening of Exons 4-9 Polymorphisms of FTO Gene in Endometrial and Ovarian Cancers [PDF]

Archives of Razi Institute, 2023
Endometrial and ovarian tumours are almost mechanistically affected by reproductive hormones. Ovarian cancer may be explained as metastatic or synchronous primary ovarian cancer, and the specific diagnosis is a challenge.
M Khudheyer Almyah, A. N2 Ayyob, R. A Al-Badran, A Issa Al-Badran   +3 more
doaj   +1 more source

Dificuldades e desafios para a educação sexual em uma escola técnica do Tocantins

Revista Sítio Novo, 2023
No âmbito da educação sexual, a escola e os educadores têm papel fundamental, podendo contribuir positivamente para uma educação integral, social e culturalmente libertadora, em que o conhecimento ultrapasse a técnica e o conteúdo dos currículos das ...
ALINE DE SOUSA SILVA, Mary Lúcia Gomes Silveira de Senna, Rivadavia Porto Cavalcante, Weimar Silva Castilho   +3 more
doaj   +1 more source

FTO promotes liver inflammation by suppressing m6A mRNA methylation of IL-17RA

Frontiers in Oncology, 2022
BackgroundPrevious studies have demonstrated that inflammation-related interleukin-17 (IL-17) signaling plays a pivotal role in the pathogenesis of non-alcoholic steatohepatitis (NASH)- and alcoholic liver disease (ALD)-induced hepatocellular carcinoma ...
Xiaojie Gan, Xiaojie Gan, Zhihui Dai, Chunmei Ge, Haozan Yin, Yuefan Wang, Jian Tan, Shuhan Sun, Weiping Zhou, Shengxian Yuan, Fu Yang   +10 more
doaj   +1 more source

FTO genotypes (rs9939609 T>A) are Associated with Increased Added Sugar Intake in Healthy Young Adults

Lifestyle Genomics, 2023
Introduction: Single-nucleotide polymorphism (SNP) rs9939609 in the FTO gene has been associated with dietary intake and appetite traits, mainly in participants with obesity; however, it remains widely unexplored in normal weight participants.
Andrea Madrigal-Juarez, Erika Martínez-López, Tania Sanchez-Murguia, Lisset Magaña-de la Vega, Roberto Rodriguez-Echevarria, Maricruz Sepulveda-Villegas, Rafael Torres-Valadez, Nathaly Torres-Castillo   +7 more
doaj   +1 more source

FTO, obesity and the adolescent brain [PDF]

Human Molecular Genetics, 2012
Genetic variations in fat mass- and obesity (FTO)-associated gene, a well-replicated gene locus of obesity, appear to be associated also with reduced regional brain volumes in elderly. Here, we examined whether FTO is associated with total brain volume in adolescence, thus exploring possible developmental effects of FTO.
Melka, M. G., Gillis, J., Bernard, M., Abrahamowicz, M., Chakravarty, M. M., Leonard, G. T., Perron, M., Richer, L., Veillette, S., Banaschewski, T., Barker, G. J., BüChel, C., Conrod, P., Flor, H., Heinz, A., Garavan, H., Brühl, R., Mann, K., Artiges, E., Lourdusamy, A., Lathrop, M., Loth, E., Schwartz, Y., Frouin, V., Rietschel, M., Smolka, M. N., hle, A., Gallinat, J., Struve, M., Lattka, E., Waldenberger, M., Schumann, G., Pavlidis, P., Gaudet, D., Paus, T., Pausova, Z.   +35 more
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m6A RNA demethylase FTO promotes the growth, migration and invasion of pancreatic cancer cells through inhibiting TFPI-2

Epigenetics, 2022
Pancreatic cancer (PC) is one of the most fatal cancers with a very poor prognosis. Here, we found that N6-methyladenosine (m6A) RNA demethylase fat mass and obesity-related protein (FTO) promote the growth, migration and invasion of PC.
Wei Wang, Ying He, Lu-Lu Zhai, Long-Jiang Chen, Li-Chao Yao, Lun Wu, Zhi-Gang Tang, Jin-Zhuo Ning   +7 more
doaj   +1 more source

Revealing the catalytic strategy of FTO

Chem Catalysis, 2023
The fat-mass and obesity-associated protein (FTO) is a Fe(II) and 2-oxoglutarate (2OG)-dependent oxygenase of the AlkB family and is linked with obesity and cancer. The enzyme is identified as single-stranded DNA/RNA demethylase with N6-methyladenine (m6A) modification in RNA as its most favorable substrate.
Ann, Varghese, Sodiq O, Waheed, Shobhit S, Chaturvedi, Isabella, DiCastri, Ciara, LaRouche, Brendan, Kaski, Nicolai, Lehnert, Deyu, Li, Christo Z, Christov, Tatyana G, Karabencheva-Christova   +9 more
openaire   +2 more sources

Effects of epigallocatechin gallate on total antioxidant capacity, biomarkers of systemic low-grade inflammation and metabolic risk factors in patients with type 2 diabetes mellitus: the role of FTO-rs9939609 polymorphism

Archives of Medical Science, 2020
Introduction Type 2 diabetes mellitus (T2DM) is known as one of the most common metabolic diseases and FTO polymorphism has been implicated in the susceptibility to this disease.
Seyedahmad Hosseini, Meysam Alipour, Mehrnoosh Zakerkish, Bahman Cheraghian, Pegah Ghandil   +4 more
doaj   +1 more source

FTO polymorphisms in oceanic populations [PDF]

Journal of Human Genetics, 2007
It has been suggested that Neel's "thrifty genotype" model may account for high body weights in some Oceanic populations, which presumably arose in modern times. In European populations, common variants (rs1421085-C, rs17817449-G, and rs9939609-A) in the fat mass and obesity (FTO associated) were recently found to be associated with body mass index ...
Jun, Ohashi, Izumi, Naka, Ryosuke, Kimura, Kazumi, Natsuhara, Taro, Yamauchi, Takuro, Furusawa, Minato, Nakazawa, Yuji, Ataka, Jintana, Patarapotikul, Pornlada, Nuchnoi, Katsushi, Tokunaga, Takafumi, Ishida, Tsukasa, Inaoka, Yasuhiro, Matsumura, Ryutaro, Ohtsuka   +14 more
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FTO Gene Polymorphisms and Their Roles in Acromegaly

International Journal of Molecular Sciences, 2023
The major causes of both morbidity and mortality in patients with acromegaly are cardiovascular diseases (CVDs). The polymorphisms of the fat mass and obesity-associated gene (FTO) are associated with obesity, as well as with an increased risk of CVDs. The aim of the study was to determine the relationship of risk alleles of four FTO gene polymorphisms
Aleksandra Jawiarczyk-Przybyłowska, Justyna Kuliczkowska-Płaksej, Katarzyna Kolačkov, Agnieszka Zembska, Jowita Halupczok-Żyła, Małgorzata Rolla, Michał Miner, Marcin Kałużny, Marek Bolanowski   +8 more
openaire   +2 more sources