Results 21 to 30 of about 41,205 (261)

Calmodulin as Ca2+-Dependent Interactor of FTO Dioxygenase [PDF]

, 2021
FTO is an N6-methyladenosine demethylase removing methyl groups from nucleic acids. Several studies indicate the creation of FTO complexes with other proteins. Here, we looked for regulatory proteins recognizing parts of the FTO dioxygenase region.
Karolina Ferenc, Oleksandr Skorobogatov, Damian Garbicz, Garbicz, Damian, Jan Piwowarski, Jarosław Poznański, Marcinkowski, Michał, Grzesiuk, Elzbieta, Ferenc, Karolina, Poznański, Jarosław, Piwowarski, Jan, Pilžys, Tomaš, Przygońska, Kaja, Winiewska-Szajewska, Maria, Kaja Przygońska, Skorobogatov, Oleksandr, Tomaš Pilžys, Elżbieta Grzesiuk, Maria Winiewska-Szajewska, Michał Marcinkowski   +19 more
core   +1 more source

Atomic layer deposited films of Al2O3 on fluorine-doped tin oxide electrodes: stability and barrier properties

Beilstein Journal of Nanotechnology, 2021
Al2O3 layers were deposited onto electrodes by atomic layer deposition. Solubility and electron-transport blocking were tested. Films deposited onto fluorine-doped tin oxide (FTO, F:SnO2/glass) substrates blocked electron transfer to redox couples ...
Hana Krýsová, Michael Neumann-Spallart, Hana Tarábková, Pavel Janda, Ladislav Kavan, Josef Krýsa   +5 more
doaj   +1 more source

PERAN VARIASI GEN FTO PADA OBESITAS [PDF]

, 2021
Genetic factors contribute to the incidence of obesity. Genetic variations in genes involved in appetite regulation, energy expenditure, fat cell differentiation and lipid metabolism play a role in obesity. Population genetic studies have identified that

core   +3 more sources

Insulin Nanoemulsion Eye Drops for the Treatment of Dry Eye Disease in Sjögren’s Disease: A Randomized Clinical Trial Phase I/II

Vision
Dry eye disease (DED) is a hallmark of primary Sjögren’s disease (SjD) and often resists conventional treatments like lubricant eye drops. Insulin nanoemulsions offer a potential solution by improving drug penetration and retention on the ocular surface.
Mateus Maia Marzola, Diego Rocha Gutierrez, Beatriz Carneiro Cintra, Adriana de Andrade Batista Murashima, Luciana Facco Dalmolin, Denny Marcos Garcia, Renata Fonseca Vianna Lopez, Fabiola Reis Oliveira, Eduardo Melani Rocha   +8 more
doaj   +1 more source

A fat mass and obesity-associated gene polymorphism influences fat mass in exercise-trained individuals

Journal of the International Society of Sports Nutrition, 2018
Background A single nucleotide polymorphism (SNP) in the fat mass and obesity-associated (FTO) gene is a strong predictor of obesity in humans. The FTO SNP (rs1421085) results in a T to C nucleotide substitution that may result in an increased risk for ...
Jose Antonio, Sarah Knafo, Ritishka Kapoor, Jaime L. Tartar   +3 more
doaj   +1 more source

Big Data on Climatic and Environmental Parameters Associated with Acute Ocular Surface Symptoms and Therapeutic Assessment: Eye Drops Sales, Google Trends and Environmental Changes

Vision
Ocular surface (OS) and dry eye (DE) symptoms are frequent ophthalmic complaints influenced by climate and pollution related with acute and chronic ocular surface symptoms.
Felipe Barbosa Galvão Azzem Ferraz, Mateus Maia Marzola, Marina Zilio Fantucci, Adriana de Andrade Batista Murashima, Beatriz Carneiro Cintra, Denny Marcos Garcia, Eduardo Melani Rocha   +6 more
doaj   +1 more source

Genetic variation rs1121980 in the fat mass and obesity-associated gene (FTO) is associated with dietary intake in Koreans

Food & Nutrition Research, 2022
Background: Fat mass and obesity-associated gene (FTO) is a well-known gene associated with body weight and obesity risk. Recent studies have suggested that genetic variations in FTO may play a role in the regulation of food preference and consumption ...
Young Goh, Jeong-Hwa Choi
doaj   +1 more source

Hepatic Lipid Stress Drives Metabolic Dysfunction‐Associated Steatohepatitis Progression through FTO O‐GlcNAcylation‐Induced m6A Demethylation of HRAS [PDF]

Advanced science
Lipid stress drives O‐GlcNAcylation of the m6A demethylase FTO at Ser195, enhancing its stability and demethylase activity. This modification removes m6A from HRAS mRNA, preventing its degradation and activating PI3K/AKT signaling to promote hepatic steatosis and inflammation.
Yin J, Zhang Y, Liu Q, Liu R, Yuan H, Chen S, Zheng M, Wang K, Tang N, Huang A.   +9 more
europepmc   +2 more sources

β‐Adducin Restrains PLA2G4A‐Dependent Lysosomal Membrane Permeabilization and Neuronal Death in Ischemic Stroke [PDF]

Advanced science
This study identifies β‐adducin as a regulator of lysosomal integrity in ischemic neurons. Ischemia‐associated FTO loss increases m6A modification and destabilizes Add2 mRNA, reducing β‐adducin expression and promoting PLA2G4A accumulation at lysosomes.
Li H, Liu P, Wu D, Ma F, Bai Y, Xia S, Yang H, Bao X, Xu Y, Cao X.   +9 more
europepmc   +2 more sources

The obesity associated FTO gene polymorphism and the risk of preeclampsia in Iranian women: A case–control study

Hypertension in Pregnancy, 2023
Background Preeclampsia (PE) is one of the leading disorders in pregnant women with maternal and fetal complications. Obesity is considered an important risk factor for the development of PE.
Ghasem Azizi-Tabesh, Hossein Sadeghi, Arezoo Farhadi, Mohammad Foad Heidari, Aghdas Safari, Mehdi Shakouri Khomartash, Javad Behroozi, Saeid Doaei, Maryam Gholamalizadeh   +8 more
doaj   +1 more source