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A Cross‐Sectional Study Investigating the Relationship Between the FTO Gene Polymorphism in Relation to Obesity Traits and Vitamin D Status in Adolescence [PDF]

Obesity Science & Practice
Background and Objective Obesity affects 18%–25% of adolescents globally and represents a major public health challenge. Genetic factors contribute to obesity susceptibility, with the FTO gene variant rs9939609 consistently associated with obesity in ...
Ahmad Al‐Serri, Rabeah A. Al‐Temaimi, Abdullah Al‐Taiar, Lemia Shaban, Reem Al‐Sabah, Abdur Rahman, Ali H. Ziyab   +6 more
doaj   +3 more sources

Effects of FTO Gene rs9939609 and rs17817449 Polymorphisms on Insulin Resistance in Turkish Children With Obesity [PDF]

Journal of Diabetes
Backgrounds Fat mass and obesity‐related gene (FTO) has been associated with glucose homeostasis and insulin sensitivity in some populations. The aim of this study was to evaluate the association of FTO gene rs9939609 and rs17817449 polymorphisms with ...
Merve Köksal, Mehtap Ünlü Söğüt, Sevtap Kabalı   +2 more
doaj   +3 more sources

'Fat mass and obesity associated' gene (FTO): No significant association of variant rs9939609 with weight loss in a lifestyle intervention and lipid metabolism markers in German obese children and adolescents [PDF]

BMC Medical Genetics, 2008
Background We have previously identified strong association of six single nucleotide polymorphisms (SNPs) in FTO (fat mass and obesity associated gene) to early onset extreme obesity within the first genome wide association study (GWA) for this phenotype.
Müller Timo D, Hinney Anke, Scherag André, Nguyen Thuy T, Schreiner Felix, Schäfer Helmut, Hebebrand Johannes, Roth Christian L, Reinehr Thomas   +8 more
doaj   +3 more sources

Involvement of the FTO A > T polymorphism in body composition and lipid profile changes after aerobic training in adults with overweight and obesity. [PDF]

Diabetes Obes Metab
Diabetes, Obesity and Metabolism, Volume 28, Issue 5, Page 4361-4365, May 2026.
Fonseca H, Cardoso G, Araújo G, Barreto E, Ribeiro M, Pereira A, Marinho C, Sousa B, Ferreira V, Toscano L, Silva R, Assis T, Persuhn D, Silva A.   +13 more
europepmc   +2 more sources

FTO rs9939609 and rs17817449 polymorphisms contribute to metabolic syndrome risk by increasing triglyceride and glucose levels [PDF]

Frontiers in Genetics
Background and AimsThe polymorphisms in fat mass and obesity-associated gene (FTO) have been implicated in metabolic dysregulation. This study aimed to investigate the associations between the FTO rs9939609 and rs17817449 polymorphisms and MetS risk, and
Yongyan Song, Ting Wang, Mi Su, Xue Wang, Youjin Zhang, Jia Pan, Yunhan Wang, Jin Yang   +7 more
doaj   +2 more sources

Exploring the Association of FTO rs9939609 with Type 2 Diabetes, Fasting Glucose and HbA1c in a Southeastern Mexican Region of Predominant Mayan Genetic Background [PDF]

Biomolecules
Type 2 diabetes (T2D) is a multifactorial disease characterized by chronic hyperglycemia. The FTO variant rs9939609 has been widely associated with obesity, but emerging evidence suggests a broader role for T2D risk across diverse populations.
Nicolas Fragoso-Bargas, Litzy Naomi Toloza-Couoh, Irma Quintal-Ortiz, Guillermo Valencia-Pacheco, Nina Valadez-Gonzalez   +4 more
doaj   +2 more sources

The Link Between Spontaneous Abortion and Vitamin E may be Influenced by the Fat Mass and Obesity-Associated Gene, a Case-Control Study. [PDF]

Health Sci Rep
ABSTRACT Background and Aims Spontaneous abortion (SA) may be affected by several variables including genetics and lifestyle factors. A recent study discovered that variations in the FTO gene have been associated to both SA and dietary intake. The objective of the study is to examine the association between vitamin E and abortion in individuals with ...
Saeedirad Z, Mousavi Mele M, Shamsi-Goushki A, Khodarahmi S, Mirshafaei MA, Tahavorgar A, Nami S, Namakian Yazdi SA, Lahiji NP, Mobarakeh KA, Khoshdooz S, Doaei S, Ajami M, Gholamalizadeh M.   +13 more
europepmc   +2 more sources

FTO at rs9939609, food responsiveness, emotional control and symptoms of ADHD in preschool children. [PDF]

PLoS ONE, 2012
The FTO minor allele at rs9939609 has been associated with body mass index (BMI: weight (kg)/height (m)(2)) in children from 5 years onwards, food intake, and eating behaviour.
Fleur P Velders, Jolanda E De Wit, Pauline W Jansen, Vincent W V Jaddoe, Albert Hofman, Frank C Verhulst, Henning Tiemeier   +6 more
doaj   +8 more sources

Genetics of Common Obesity in Children and Adolescents. [PDF]

Ann N Y Acad Sci
Abstract Childhood obesity is a multifactorial public health problem worldwide. Genetic variation influences the predisposition to develop obesity at early stages of life. Childhood obesity may be classified as syndromic, monogenic, or polygenic depending on the genetic component.
León-Reyes G, Alavez FJL, Tejero ME.
europepmc   +2 more sources

Breastfeeding moderates the relationship between fat mass and obesity‐associated gene rs9939609 and body mass index among adolescents

Obesity Science and Practice, 2022
Objective Breastfeeding, which is important for early growth, is a possible moderator of genetic influence, such as the effect of the fat mass and obesity‐associated gene (FTO) on body mass index (BMI).
Sofia Helena Kanders, Kent W Nilsson, Cecilia Åslund   +2 more
exaly   +2 more sources