Results 41 to 50 of about 2,096 (161)

Association of Fat Mass and Obesity-associated Gene (FTO) rs9939609 Variant with Early Onset Obesity among Bataknese and Chinese Children in Indonesia: A Case-control Study

Indonesian Biomedical Journal, 2017
BACKGROUND: Childhood obesity is associated with the risk of adult obesity and obesity-related chronic disease. The fat mass and obesity-associated gene (FTO) rs9939609 variant are of particular interest because of its association with body mass index ...
Siska Mayasari Lubis, Miswar Fattah, Harun Alrasyid Damanik, Jose Rizal Latief Batubara   +3 more
doaj   +1 more source

Gene sequence variants PPARGC1Ars8192678, PPARG2rs1801282, FTORS9939609, LEPRS7799039 and LEPRRS1137101 in non-alcoholic fatty liver disease [PDF]

Saratov Medical Journal, 2023
Objective: assessing the association of sequence variants rs8192678, rs1801282, rs9939609, rs7799039 and rs1137101in PPARGC1A, PPARG2, FTO, LEP and LEPR genes, respectively,with non-alcoholic fatty liver disease (NAFLD) inyounger adults (18-44 years ...
Pankova, Ekaterina D. , Chulkov, Vasiliy S. , Gavrilova, Elena S. , Zotova, Maria A. , Sumerkina, Veronika A. , Zhmaylova, Svetlana V. , Okonenko, Tatiana I.   +6 more
doaj   +1 more source

In depth analysis of the association of FTO SNP (rs9939609) with the expression of classical phenotype of PCOS: a Sri Lankan study

BMC Medical Genetics, 2020
Background PCOS is a common disorder of women due to genetic, endocrine and environmental effects that manifests from puberty. The rs9939609 variant of fat mass and obesity associated (FTO) gene is linked to metabolic derangement in PCOS.
Umayal Branavan, Sulochana Wijesundera, Vishvanath Chandrasekaran, Carukshi Arambepola, Chandrika Wijeyaratne   +4 more
doaj   +1 more source

'Fat mass and obesity associated' gene (FTO): No significant association of variant rs9939609 with weight loss in a lifestyle intervention and lipid metabolism markers in German obese children and adolescents

BMC Medical Genetics, 2008
Background We have previously identified strong association of six single nucleotide polymorphisms (SNPs) in FTO (fat mass and obesity associated gene) to early onset extreme obesity within the first genome wide association study (GWA) for this phenotype.
Müller Timo D, Hinney Anke, Scherag André, Nguyen Thuy T, Schreiner Felix, Schäfer Helmut, Hebebrand Johannes, Roth Christian L, Reinehr Thomas   +8 more
doaj   +1 more source

The obesity associated FTO gene polymorphism and the risk of preeclampsia in Iranian women: A case–control study

Hypertension in Pregnancy, 2023
Background Preeclampsia (PE) is one of the leading disorders in pregnant women with maternal and fetal complications. Obesity is considered an important risk factor for the development of PE.
Ghasem Azizi-Tabesh, Hossein Sadeghi, Arezoo Farhadi, Mohammad Foad Heidari, Aghdas Safari, Mehdi Shakouri Khomartash, Javad Behroozi, Saeid Doaei, Maryam Gholamalizadeh   +8 more
doaj   +1 more source

The Association of Fat-Mass-and Obesity-Associated Gene Polymorphism (rs9939609) With Colorectal Cancer: A Case-Control Study

Frontiers in Oncology, 2021
Background and AimThe association between the rs9939609 polymorphism of fat mass and obesity-associated gene (FTO) and risk of colorectal cancer is controversial.
Maryam Gholamalizadeh, Mohammad Esmail Akbari, Saeid Doaei, Sayed Hossein Davoodi, Bojlul Bahar, Ghasem Azizi Tabesh, Hossein Sadeghi, Melika Razavi Hashemi, Elham Kheyrani, Samira Rastgoo, Azadeh Hajipour, Zahra Aslany, Reza Mirfakhraie, Alireza Mosavi Jarrahi   +13 more
doaj   +1 more source

Association of FTO rs9939609 SNP with Obesity and Obesity- Associated Phenotypes in a North Indian Population [PDF]

Oman Medical Journal, 2016
Objectives: Obesity is a common disorder that has a significant impact on morbidity and mortality. Twin and adoption studies support the genetic influence on variation of obesity, and the estimates of the heritability of body mass index (BMI) is ...
Jai Prakash, Balraj Mittal, Apurva Srivastava, Shally Awasthi, Neena Srivastava   +4 more
doaj   +1 more source

FTO at rs9939609, food responsiveness, emotional control and symptoms of ADHD in preschool children. [PDF]

PLoS ONE, 2012
The FTO minor allele at rs9939609 has been associated with body mass index (BMI: weight (kg)/height (m)(2)) in children from 5 years onwards, food intake, and eating behaviour.
Fleur P Velders, Jolanda E De Wit, Pauline W Jansen, Vincent W V Jaddoe, Albert Hofman, Frank C Verhulst, Henning Tiemeier   +6 more
doaj   +1 more source

N6‐Methyladenosine (m6A) in Liver Disease: Pathogenic Mechanisms and Therapeutic Potential

iNew Medicine, Volume 2, Issue 2, June 2026.
ABSTRACT Accumulating evidence highlights the critical role of epigenetic modifications, particularly N6‐methyladenosine (m6A), in liver disease. As the most abundant RNA modification in eukaryotic cells, m6A is dynamically regulated by multicomponent m6A methyltransferases (e.g., METTL3 and METTL14), demethylases (FTO and ALKBH5), and m6A‐binding ...
Yingfen Chen, Ru Ya, Ziling Zhang, Siyue Dong, Seol Hee Park, Wonhyo Seo, Yong He   +6 more
wiley   +1 more source

An Obesity-Related FTO Variant and the Risk of Preeclampsia in a Finnish Study Population

Journal of Pregnancy, 2011
Previous studies have demonstrated a common variant of the obesity and fat mass-related FTO gene, rs9939609, to be associated with obesity, type 2 diabetes, and elevated blood pressure. We investigated whether the FTO SNP rs9939609 is associated with the
Miira Klemetti, Leena M. Hiltunen, Sanna Heino, Seppo Heinonen, Eero Kajantie, Hannele Laivuori   +5 more
doaj   +1 more source