FTO Gene Polymorphisms and Their Roles in Acromegaly. [PDF]
Int J Mol Sci, 2023 The major causes of both morbidity and mortality in patients with acromegaly are cardiovascular diseases (CVDs). The polymorphisms of the fat mass and obesity-associated gene (FTO) are associated with obesity, as well as with an increased risk of CVDs ...
Jawiarczyk-Przybyłowska A +8 more
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Studies on the fat mass and obesity-associated (FTO) gene and its impact on obesity-associated diseases [PDF]
Genes and Diseases, 2023 Obesity has become a major health crisis in the past ∼50 years. The fat mass and obesity-associated (FTO) gene, identified by genome-wide association studies (GWAS), was first reported to be positively associated with obesity in humans.
Chaoqun Huang, Wei Chen, Xinxia Wang
doaj +3 more sources
FTO Gene Polymorphisms at the Crossroads of Metabolic Pathways of Obesity and Epigenetic Influences [PDF]
Food Technology and Biotechnology, 2023 In this review, we summarize the current state of knowledge on the fat mass and obesity-associated (FTO) gene and its role in obesity. The FTO-encoded protein is involved in multiple molecular pathways contributing to obesity as well as other metabolic ...
Ana-Marija Popović +5 more
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FTO gene expression in diet-induced obesity is downregulated by Solanum fruit supplementation [PDF]
Open Life Sciences, 2022 The Fat Mass and Obesity-associated (FTO) gene has been shown to play an important role in developing obesity, manifesting in traits such as increased body mass index, increased waist-to-hip ratio, and the distribution of adipose tissues, which increases
Asuquo Edeke Affiong +5 more
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Association of FTO gene variant rs9939609 with polycystic ovary syndrome from Gujarat, India. [PDF]
BMC Med Genomics, 2023 Background Polycystic ovary syndrome is a multifactorial endocrine disorder impacting women of reproductive age. Variations within the FTO gene have been linked to both obesity and type 2 diabetes mellitus.
Chaudhary H +5 more
europepmc +2 more sources
Impact of the FTO Gene Variation on Appetite and Fat Oxidation in Young Adults. [PDF]
Nutrients, 2023 The FTO rs9939609 gene, which presents three polymorphisms (AA, AT, and TT), has been associated with the development of obesity through an increased fat accumulation; however, the associations of the gene with other physiological mechanisms, such as ...
Ponce-Gonzalez JG +7 more
europepmc +2 more sources
Effects of Helicobacter pylori on the expression of the FTO gene and its biological role in gastric cancer. [PDF]
Oncol Lett, 2023 Helicobacter pylori (Hp) is a primary risk factor for gastric cancer. The fat mass and obesity-associated (FTO) gene is associated with the development and progression of various cancer types such as glioma, leukemia, breast cancer and colorectal cancer.
Gui S +9 more
europepmc +2 more sources
Emerging Role and Mechanism of the FTO Gene in Cardiovascular Diseases. [PDF]
Biomolecules, 2023 The fat mass and obesity-associated (FTO) gene was the first obesity-susceptibility gene identified through a genome-wide association study (GWAS). A growing number of studies have suggested that genetic variants of FTO are strongly associated with the ...
Xu ZY, Jing X, Xiong XD.
europepmc +2 more sources
Unraveling the Complex Interactions between the Fat Mass and Obesity-Associated (FTO) Gene, Lifestyle, and Cancer. [PDF]
Adv Nutr, 2022 Carcinogenesis as a complicated process originates from genetic, epigenetic, and environmental factors. Recent studies have reported a potential critical role for the fat mass and obesity-associated (FTO) gene in carcinogenesis through different ...
Abdollahi S +6 more
europepmc +2 more sources
Ramadan Diurnal Intermittent Fasting Is Associated With Attenuated FTO Gene Expression in Subjects With Overweight and Obesity: A Prospective Cohort Study. [PDF]
Front Nutr, 2021 Aim and Background A growing body of evidence supports the impact of intermittent fasting (IF) on normalizing body weight and that the interaction between body genes and environmental factors shapes human susceptibility to developing obesity. FTO gene is
Madkour MI +5 more
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