Results 1 to 10 of about 15,826 (205)

Studies on the fat mass and obesity-associated (FTO) gene and its impact on obesity-associated diseases [PDF]

Genes and Diseases, 2023
Obesity has become a major health crisis in the past ∼50 years. The fat mass and obesity-associated (FTO) gene, identified by genome-wide association studies (GWAS), was first reported to be positively associated with obesity in humans.
Chaoqun Huang, Wei Chen, Xinxia Wang
doaj   +4 more sources

Fat Mass and Obesity-Related (FTO) Gene Variant Is a Predictor of CVD in T2DM Patients [PDF]

Journal of Diabetes Research
Conclusion: The FTO gene variant rs9939609 has a strong association with T2DM and CVD. The AA genotype of FTO gene variants rs9939609 showed a strong association with most of the risk factors of CVD and T2DM.
Mazhar Hussain, Akbar Waheed, Asim Elahi, Ghulam Mustafa   +3 more
doaj   +3 more sources

Relationship of FTO gene variations with NAFLD risk in Chinese men

Open Life Sciences, 2020
Fat mass and obesity-associated (FTO) gene is an obesity susceptibility gene and its relationship with the nonalcoholic fatty liver disease (NAFLD) remains unclear.
Chen Xuefen, Gao Yong, Yang Xiaobo, Zhang Haiying, Mo Zengnan, Tan Aihua   +5 more
doaj   +4 more sources

FTO Gene Polymorphisms and Their Roles in Acromegaly. [PDF]

Int J Mol Sci, 2023
The major causes of both morbidity and mortality in patients with acromegaly are cardiovascular diseases (CVDs). The polymorphisms of the fat mass and obesity-associated gene (FTO) are associated with obesity, as well as with an increased risk of CVDs. The aim of the study was to determine the relationship of risk alleles of four FTO gene polymorphisms
Jawiarczyk-Przybyłowska A, Kuliczkowska-Płaksej J, Kolačkov K, Zembska A, Halupczok-Żyła J, Rolla M, Miner M, Kałużny M, Bolanowski M.   +8 more
europepmc   +3 more sources

Changes in gene expression associated with FTO overexpression in mice.

PLoS ONE, 2014
Single nucleotide polymorphisms in the first intron of the fat-mass-and-obesity-related gene FTO are associated with increased body weight and adiposity. Increased expression of FTO is likely underlying this obesity phenotype, as mice with two additional
Myrte Merkestein, James S McTaggart, Sheena Lee, Holger B Kramer, Fiona McMurray, Mathilde Lafond, Lily Boutens, Roger Cox, Frances M Ashcroft   +8 more
doaj   +5 more sources

The IRX3 Gene; the Missing Link between the FTO Gene and Obesity

Asian Pacific Journal of Cancer Biology, 2016
Aims: The aim of this study was the investigation of the mediator role of the IRX3 gene in the relationship between the FTO gene and obesity. Materials and Methods: All related articles published in English from June 1990 to February 2017 were studied ...
Saeid Doaei, Maryam Gholamalizadeh, Alireza Mousavi Jarrahi, Marjan Badakhanian, Rahim Najafi   +4 more
doaj   +4 more sources

FTO Gene Polymorphisms at the Crossroads of Metabolic Pathways of Obesity and Epigenetic Influences [PDF]

Food Technology and Biotechnology, 2023
In this review, we summarize the current state of knowledge on the fat mass and obesity-associated (FTO) gene and its role in obesity. The FTO-encoded protein is involved in multiple molecular pathways contributing to obesity as well as other metabolic ...
Ana-Marija Popović, Ana Huđek Turković, Kristina Žuna, Višnja Bačun-Družina, Ivica Rubelj, Martina Matovinović   +5 more
doaj   +2 more sources

The Effect and Molecular Mechanism of Fto Gene Knockout on Cadmium-Induced Injury in Pancreatic β-Cells [PDF]

Current Issues in Molecular Biology
Cadmium exposure results in the impairment of pancreatic β-cells. The FTO protein, the product of the Fto gene, is a key regulator of diverse pathophysiological processes, including oxidative damage and cell death. However, it remains unclear whether Fto
Sina Yang, Wenhong Li, Shunrong Ma, Ning Xu, Kaiyan Shen, Jiamin Yuan, Yanying Hu, Shiyan Gu, Zuoshun He   +8 more
doaj   +2 more sources

Involvement of an FTO gene polymorphism in the temporomandibular joint osteoarthritis. [PDF]

Clin Oral Investig, 2022
Abstract Objectives The FTO gene has been reported as an obesity-associated gene and is also considered a risk gene for osteoarthritis (OA). However, its exact function is unclear, and there is conflicting evidence on the involvement of FTO polymorphisms in OA via obesity.
Takaoka R, Kuyama K, Yatani H, Ishigaki S, Kayashima H, Koishi Y, Kato T, Egusa H, Uchiyama Y, Nakatani A, Shimamoto H.   +10 more
europepmc   +4 more sources

The Role of FTO Genotype in the Association Between FTO Gene Expression and Anthropometric Measures in Obese and Overweight Adolescent Boys [PDF]

American Journal of Men's Health, 2019
The role of FTO genotype in the effect of FTO gene expression level on change in body mass index and body composition has not been studied. This study aimed to investigate the role of FTO genotype in the association between change in the expression level
Saeid Doaei, Naser Kalantari, Nastaran Keshavarz Mohammadi, Pantea Izadi, Maryam Gholamalizadeh, Hassan Eini-Zinab, Tuire Salonurmi, Alireza Mosavi Jarrahi, Shahram Rafieifar, Rahim Najafi, Mahnaz Sadeghypor, Ghasem Azizi Tabesh, Mark O. Goodarzi   +12 more
doaj   +4 more sources