Results 41 to 50 of about 15,826 (205)
Gene Variants Are Associated with PCOS Susceptibility and Hyperandrogenemia in Young Korean Women [PDF]
Diabetes & Metabolism Journal, 2014 BackgroundThe fat mass and obesity-associated (FTO) gene is associated with obesity and type 2 diabetes mellitus. Obesity and insulin resistance are also common features of polycystic ovary syndrome (PCOS).
Do Kyeong Song +4 more
doaj +1 more source
Aging Is a Key Driver for Adult Acute Myeloid Leukemia
Aging and Cancer, EarlyView.Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley +1 more source
FTO associations with obesity and telomere length
Journal of Biomedical Science, 2017 This review examines the biology of the Fat mass- and obesity-associated gene (FTO), and the implications of genetic association of FTO SNPs with obesity and genetic aging.
Yuling Zhou +2 more
doaj +1 more source
Arquivos de Ciências da Saúde da UNIPAR, 2021 A obesidade é caracterizada pelo aumento excessivo da gordura corporal e está ligada ao estilo de vida, ao meio ambiente e a genética do indivíduo. O equilíbrio entre ingestão e gasto energético é controlado por mecanismos neurais, hormonais, químicos e
Braulio Pereira Filho +5 more
doaj +1 more source
m6A‐Mediated Glycolysis by IL‐37 Drives T Cell Metabolic Reprogramming to Regulate Colitis
Advanced Science, EarlyView.This study identifies an IL‐37/SIGIRR‐METTL14 regulatory axis that suppresses global m6A modification in CD4+ T cells. IL‐37 signaling, mediated through SIGIRR, inhibits IRAK4 and JNK phosphorylation, leading to downregulation of the methyltransferase METTL14.
Xiaoyan Wang +26 more
wiley +1 more source
The bigger picture of FTO—the first GWAS-identified obesity gene [PDF]
Nature Reviews Endocrinology, 2013 Single nucleotide polymorphisms (SNPs) that cluster in the first intron of fat mass and obesity associated (FTO) gene are associated obesity traits in genome-wide association studies. The minor allele increases BMI by 0.39 kg/m(2) (or 1,130 g in body weight) and risk of obesity by 1.20-fold.
Loos, Ruth J. F., Yeo, Giles S. H.
openaire +2 more sources
Advanced Science, EarlyView.Cigarette smoke accelerates the aging of immune cells in the lung. By combining human single‐cell sequencing, cell culture, and mouse models, the authors show that the protein GEM drives mitochondrial damage and senescence in alveolar macrophages by suppressing SIRT3.
Jin Wang +8 more
wiley +1 more source
Overexpression of demethylase-related gene FTO improves salt and drought tolerance in rapeseed
Oil Crop ScienceDrought and salt stresses are major abiotic factors that severely affect the growth, development, and yield formation of Brassica napus. Human derived FTO gene (Fat mass and obesity-associated), is a member of the AlkB family, encoding a mRNA demethylase
Yuting Zou +6 more
doaj +1 more source
Advanced Science, EarlyView.Upon JEV infection, ZNF33B recruits METTL14 to stabilize the METTL3‐METTL14 m6A methyltransferase complex, leading to increased m6A modification of host transcripts, including Trim25 mRNA. ZNF33B selectively binds m6A‐modified sites on Trim25 mRNA and accelerates its decay, resulting in reduced TRIM25 protein abundance.
Jian Du +9 more
wiley +1 more source
The effect of rs9930506 FTO gene polymorphism on obesity risk: a meta-analysis
Biomolecular Concepts, 2019 Obesity is associated with polymorphisms of the fat mass and obesity associated gene (FTO). This meta-analysis aimed to investigate the association of the rs9930506 FTO gene polymorphism and obesity.
Doaei S +11 more
doaj +1 more source