Results 21 to 30 of about 15,826 (205)

Association of serum 25-OH-vitamin D level with FTO and IRX3 genes expression in obese and overweight boys with different FTO rs9930506 genotypes

Journal of Translational Medicine, 2021
Background The roles of FTO gene and the level of serum 25-OH-vitamin D in obesity are frequently reported. This study aimed to investigate the interactions of serum 25-OH-vitamin D level, FTO and IRX3 genes expression, and FTO genotype in obese and ...
Maryam Gholamalizadeh, Saeid Doaei, Zohreh Mokhtari, Vahideh Jalili, Fatemeh Bourbour, Saeed Omidi, Kamal Ebrahimi, Naser Kalantari, Sheyda Abdi, Ghasem Azizi Tabesh, Mohammad Naimi Joubani, Esmaeil Roohbakhsh, Seyed Alireza Mosavi Jarrahi   +12 more
doaj   +1 more source

The obesity-associated Fto gene is a transcriptional coactivator [PDF]

Biochemical and Biophysical Research Communications, 2010
The fat mass and obesity associated, FTO, gene has been shown to be associated with obesity in human in several genome-wide association scans. In vitro studies suggest that Fto may function as a single-stranded DNA demethylase. In addition, homologous recombination-targeted knockout of Fto in mice resulted in growth retardation, loss of white adipose ...
Qiong, Wu, Rudel A, Saunders, Maria, Szkudlarek-Mikho, Ivana de la, Serna, Khew-Voon, Chin   +4 more
openaire   +2 more sources

Fat mass and obesity associated gene (FTO) expression is regulated negatively by the transcription factor Foxa2. [PDF]

PLoS ONE, 2012
Fat mass and obesity associated gene (FTO) is the first gene associated with body mass index (BMI) and risk for diabetes. FTO is highly expressed in the brain and pancreas, and is involved in regulating dietary intake and energy expenditure.
Jianjin Guo, Wei Ren, Ying Ding, Aimei Li, Lu Jia, Dongming Su, Xiang Liu, Kuanfeng Xu, Tao Yang   +8 more
doaj   +1 more source

The association between FTO rs9939609 polymorphism and serum lipid profile in adult women

Diabetology & Metabolic Syndrome, 2021
Background FTO gene is considered to play an important role in many metabolic diseases. Evidence from studies indicated the possible association between the FTO rs9939609 polymorphisms with serum lipid profile.
Vahideh Jalili, Zohreh Mokhtari, Samira Rastgoo, Azadeh Hajipour, Fatemeh Bourbour, Maryam Gholamalizadeh, Alireza Mosavi Jarrahi, Sepehr JavadiKooshesh, Alireza Moslem, Morteza Abdollahi, Saeid Doaei   +10 more
doaj   +1 more source

FTO gene polymorphisms and obesity risk: a meta-analysis [PDF]

BMC Medicine, 2011
Abstract Background The pathogenesis of obesity is reportedly related to variations in the fat mass and an obesity-associated gene (FTO); however, as the number of reports increases, particularly with respect to varying ethnicities, there is a need to determine more precisely the effect sizes in each ethnic group.
Li Xiaobo, Ren Xiaobin, Xu Fangying, Zhu Yimin, Peng Sihua, Lai Maode   +5 more
openaire   +3 more sources

Variations in the FTO gene are associated with severe obesity in the Japanese [PDF]

Journal of Human Genetics, 2008
Variations in the fat-mass and obesity-associated gene (FTO) are associated with the obesity phenotype in many Caucasian populations. This association with the obesity phenotype is not clear in the Japanese. To investigate the relationship between the FTO gene and obesity in the Japanese, we genotyped single nucleotide polymorphisms (SNPs) in the FTO ...
Hotta, Kikuko, Nakata, Yoshio, Matsuo, Tomoaki, Kamohara, Seika, Kotani, Kazuaki, Komatsu, Ryoya, Itoh, Naoto, Mineo, Ikuo, Wada, Jun, Masuzaki, Hiroaki, Yoneda, Masato, Nakajima, Atsushi, Miyazaki, Shigeru, Tokunaga, Katsuto, Kawamoto, Manabu, Funahashi, Tohru, Hamaguchi, Kazuyuki, Yamada, Kentaro, Hanafusa, Toshiaki, Oikawa, Shinichi, Yoshimatsu, Hironobu, Nakao, Kazuwa, Sakata, Toshiie, Matsuzawa, Yuji, Tanaka, Kiyoji, Kamatani, Naoyuki, Nakamura, Yusuke   +26 more
openaire   +2 more sources

Impact of m6A demethylase (ALKBH5, FTO) genetic polymorphism and expression levels on the development of pulmonary tuberculosis

Frontiers in Cellular and Infection Microbiology, 2022
ObjectiveThe m6A methylation was involved in the pathogenesis of pulmonary tuberculosis (PTB), and our study aimed to reveal the potential association of m6A demethylase (ALKBH5, FTO) genes variation, expression levels and PTB.MethodsEight SNPs (ALKBH5 ...
Tian-Ping Zhang, Rui Li, Li-Jun Wang, Hong-Miao Li   +3 more
doaj   +1 more source

Interaction between FTO rs9939609 and the Native American-origin ABCA1 rs9282541 affects BMI in the admixed Mexican population

BMC Medical Genetics, 2017
Background The aim of this study was to explore whether interactions between FTO rs9939609 and ABCA1 rs9282541 affect BMI and waist circumference (WC), and could explain previously reported population differences in FTO-obesity and FTO-BMI associations ...
Marisela Villalobos-Comparán, Bárbara Antuna-Puente, María Teresa Villarreal-Molina, Samuel Canizales-Quinteros, Rafael Velázquez-Cruz, Paola León-Mimila, Hugo Villamil-Ramírez, Juan Antonio González-Barrios, José Luis Merino-García, María Rocío Thompson-Bonilla, Diego Jarquin, Osvaldo Erik Sánchez-Hernández, Martha Eunice Rodríguez-Arellano, Carlos Posadas-Romero, Gilberto Vargas-Alarcón, Francisco Campos-Pérez, Manuel Quiterio, Jorge Salmerón-Castro, Alessandra Carnevale, Sandra Romero-Hidalgo   +19 more
doaj   +1 more source

Interactions between macro-nutrients’ intake, FTO and IRX3 gene expression, and FTO genotype in obese and overweight male adolescents

Adipocyte, 2019
This study is the first to identify the effects of FTO genotype on the interactions between the level of macro-nutrients intake and the expression level of fat mass and obesity associated (FTO) and homeobox transcription factor iriquois-3 (IRX3) genes ...
Saeid Doaei, Naser Kalantari, Pantea Izadi, Tuire Salonurmi, Alireza Mosavi Jarrahi, Shahram Rafieifar, Ghasem Azizi Tabesh, Ghazaleh Rahimzadeh, Maryam Gholamalizadeh, Mark O. Goodarzi   +9 more
doaj   +1 more source

THE ROLE OF FAT MASS AND OBESITY-ASSOCIATED GENE POLYMORPHISM IN OBESE EGYPTIANS [PDF]

Al-Azhar Journal of Pharmaceutical Sciences, 2014
Introduction: Variations in fat mass and obesity associated (FTO) gene increased the risk of obesity in many European populations but with inconclusive results in other populations.
Mina Khella
doaj   +1 more source