Results 21 to 30 of about 2,549,001 (246)

The Effect and Molecular Mechanism of Fto Gene Knockout on Cadmium-Induced Injury in Pancreatic β-Cells [PDF]

Current Issues in Molecular Biology
Cadmium exposure results in the impairment of pancreatic β-cells. The FTO protein, the product of the Fto gene, is a key regulator of diverse pathophysiological processes, including oxidative damage and cell death. However, it remains unclear whether Fto
Sina Yang, Wenhong Li, Shunrong Ma, Ning Xu, Kaiyan Shen, Jiamin Yuan, Yanying Hu, Shiyan Gu, Zuoshun He   +8 more
doaj   +2 more sources

Fat mass and obesity associated gene (FTO) expression is regulated negatively by the transcription factor Foxa2. [PDF]

PLoS ONE, 2012
Fat mass and obesity associated gene (FTO) is the first gene associated with body mass index (BMI) and risk for diabetes. FTO is highly expressed in the brain and pancreas, and is involved in regulating dietary intake and energy expenditure.
Jianjin Guo, Wei Ren, Ying Ding, Aimei Li, Lu Jia, Dongming Su, Xiang Liu, Kuanfeng Xu, Tao Yang   +8 more
doaj   +2 more sources

The IRX3 gene; the missing link between the FTO gene and obesity

Asian Pacific Journal of Cancer Biology, 2017
Aims: The aim of this study was investigation of the mediator role of the IRX3 gene in the relationship between the FTO gene and obesity. Materials and Methods: All related articles published in English from June 1990 to February 2017 were studied ...
maryam gholamalizadeh, saeid doaei, alireza Mosavi Jarrahi, Marjan Badakhanian, Rahim Najafi   +4 more
doaj   +2 more sources

Role of rs9939506 polymorphism of FTO gene in resistance to eating in male adolescents [PDF]

BMC Pediatrics, 2023
Background Single Nucleotide Polymorphisms (SNPs) of the Fat mass and obesity-associated (FTO) gene may be associated with obesity by regulating appetite.
Ali Shaker, Soheila Shekari, Mobina Zeinalabedini, Zahra Salimi, Zahra Roumi, Khadijeh Abbasi Mobarakeh, Ali Shamsi-Goushki, Mohammad Masoumvand, Mohammad Keshavarz Mohammadian, Pegah Samani, Ghasem Azizi-Tabesh, Hanieh Shafaei, Saeid Doaei, Naser Kalantari, Maryam Gholamalizadeh   +14 more
doaj   +2 more sources

FTO gene variants and consumption of  alcoholic beverages [PDF]

Alcoholism and Drug Addiction, 2021
The aim of this review is to present the role of FTO gene sequence variation in determining predisposition to specific forms of alcohol consumption. This systematic review includes studies published in 2011-2013 and 2019 from the PubMed, Science Direct ...
Anna Karolina Flaga, Anna Mach, Grażyna Gromadzka   +2 more
doaj   +3 more sources

FTO gene expression in diet-induced obesity is downregulated by Solanum fruit supplementation [PDF]

Open Life Sciences, 2022
The Fat Mass and Obesity-associated (FTO) gene has been shown to play an important role in developing obesity, manifesting in traits such as increased body mass index, increased waist-to-hip ratio, and the distribution of adipose tissues, which increases
Asuquo Edeke Affiong, Nwodo Okwesilieze Fred Chiletugo, Assumpta Anosike Chioma, Orizu Uchendu Nene, Oziamara Okoro Nkwachukwu, Solomon Odiba Arome   +5 more
doaj   +2 more sources

The effect of rs9930506 FTO gene polymorphism on obesity risk: a meta-analysis

Biomolecular Concepts, 2019
Obesity is associated with polymorphisms of the fat mass and obesity associated gene (FTO). This meta-analysis aimed to investigate the association of the rs9930506 FTO gene polymorphism and obesity.
Doaei S, Mosavi Jarrahi SA, Sanjari Moghadam A, Akbari ME, Javadi Kooshesh S, Badeli M, Azizi Tabesh Gh, Abbas Torki S, Gholamalizadeh M, Zhu ZH, Montazeri F, Mirzaei Dahka S   +11 more
doaj   +2 more sources

Involvement of an FTO gene polymorphism in the temporomandibular joint osteoarthritis. [PDF]

Clin Oral Investig, 2022
Abstract Objectives The FTO gene has been reported as an obesity-associated gene and is also considered a risk gene for osteoarthritis (OA). However, its exact function is unclear, and there is conflicting evidence on the involvement of FTO polymorphisms in OA via obesity.
Takaoka R, Kuyama K, Yatani H, Ishigaki S, Kayashima H, Koishi Y, Kato T, Egusa H, Uchiyama Y, Nakatani A, Shimamoto H.   +10 more
europepmc   +4 more sources

Emerging Role and Mechanism of the FTO Gene in Cardiovascular Diseases. [PDF]

Biomolecules, 2023
The fat mass and obesity-associated (FTO) gene was the first obesity-susceptibility gene identified through a genome-wide association study (GWAS). A growing number of studies have suggested that genetic variants of FTO are strongly associated with the risk of cardiovascular diseases, including hypertension and acute coronary syndrome. In addition, FTO
Xu ZY, Jing X, Xiong XD.
europepmc   +4 more sources

Association of the FTO Gene With BMI [PDF]

Obesity, 2008
Variants in the FTO gene have been strongly associated with obesity in a very large sample (38,759) of diabetic and control subjects. To replicate these findings, the previously reported SNP in the FTO gene (rs9939609, T/A) was genotyped in 5,607 subjects from five different Utah studies.
Steven C, Hunt, Steven, Stone, Yuanpei, Xin, Christina A, Scherer, Charles L, Magness, Shawn P, Iadonato, Paul N, Hopkins, Ted D, Adams   +7 more
openaire   +2 more sources