Results 31 to 40 of about 2,549,001 (246)
The FTO gene and measured food intake in children [PDF]
International Journal of Obesity, 2008 Polymorphisms in the obesity-associated gene, FTO, have been linked with sensitivity to satiety in children, indicating FTO may be influencing one of the regulatory drivers underlying food intake. In this study, we tested the hypothesis that food intake in a standard eating behaviour paradigm in which palatable food is offered under conditions of ...
Wardle, J. +3 more
openaire +3 more sources
Journal of Translational Medicine, 2021 Background The roles of FTO gene and the level of serum 25-OH-vitamin D in obesity are frequently reported. This study aimed to investigate the interactions of serum 25-OH-vitamin D level, FTO and IRX3 genes expression, and FTO genotype in obese and ...
Maryam Gholamalizadeh +12 more
doaj +1 more source
The obesity-associated Fto gene is a transcriptional coactivator [PDF]
Biochemical and Biophysical Research Communications, 2010 The fat mass and obesity associated, FTO, gene has been shown to be associated with obesity in human in several genome-wide association scans. In vitro studies suggest that Fto may function as a single-stranded DNA demethylase. In addition, homologous recombination-targeted knockout of Fto in mice resulted in growth retardation, loss of white adipose ...
Qiong, Wu +4 more
openaire +2 more sources
Association of FTO gene variants rs9939609 and rs1421085 with polycystic ovary syndrome
Egyptian Journal of Medical Human Genetics, 2022 Background Polycystic ovary syndrome (PCOS) is among the most common complex genetic endocrinopathy, and its etiology and pathophysiology remain controversial.
Alaa A. Alnafjan +4 more
doaj +1 more source
Variations in the FTO gene are associated with severe obesity in the Japanese [PDF]
Journal of Human Genetics, 2008 Variations in the fat-mass and obesity-associated gene (FTO) are associated with the obesity phenotype in many Caucasian populations. This association with the obesity phenotype is not clear in the Japanese. To investigate the relationship between the FTO gene and obesity in the Japanese, we genotyped single nucleotide polymorphisms (SNPs) in the FTO ...
Hotta, Kikuko +26 more
openaire +2 more sources
Impact of FTO genotypes on BMI and weight in polycystic ovary syndrome : a systematic review and meta-analysis [PDF]
, 2012 Aims/hypothesis FTO gene single nucleotide polymorphisms (SNPs) have been shown to be associated with obesity-related traits and type 2 diabetes. Several small studies have suggested a greater than expected effect of the FTO rs9939609 SNP on weight in ...
Lerchbaum, E. +74 more
core +1 more source
The association between FTO rs9939609 polymorphism and serum lipid profile in adult women
Diabetology & Metabolic Syndrome, 2021 Background FTO gene is considered to play an important role in many metabolic diseases. Evidence from studies indicated the possible association between the FTO rs9939609 polymorphisms with serum lipid profile.
Vahideh Jalili +10 more
doaj +1 more source
FTO gene polymorphisms and obesity risk: a meta-analysis [PDF]
BMC Medicine, 2011 Abstract Background The pathogenesis of obesity is reportedly related to variations in the fat mass and an obesity-associated gene (FTO); however, as the number of reports increases, particularly with respect to varying ethnicities, there is a need to determine more precisely the effect sizes in each ethnic group.
Li Xiaobo +5 more
openaire +3 more sources
Fat Mass and Obesity-Associated Gene (FTO) in Eating Disorders: Evidence for Association of the rs9939609 Obesity Risk Allele with Bulimia nervosa and Anorexia nervosa [PDF]
, 2012 Objective: The common single nucleotide polymorphism (SNP) rs9939609 in the fat mass and obesity-associated gene (FTO) is associated with obesity. As genetic variants associated with weight regulation might also be implicated in the etiology of eating ...
Wichmann, Heinz-Erich +67 more
core +1 more source