Results 51 to 60 of about 15,826 (205)

Regulation ofFto/Ftmgene expression in mice and humans [PDF]

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 2008
Two recent, large whole-genome association studies (GWAS) in European populations have associated a ∼47-kb region that contains part of the FTO gene with high body mass index (BMI). The functions of FTO and adjacent FTM in human biology are not clear.
Stratigopoulos, G, Padilla, S, LeDuc, C, Watson, E, Hattersley, A, McCarthy, M, Zeltser, L, Chung, W, Leibel, R   +8 more
openaire   +2 more sources

RBM12 Maintains Glioma Stem Cells by Activating Amino Acid‐Dependent mTORC1 Signaling via SLC7A5 mRNA Stabilization

Advanced Science, EarlyView.
This study shows that in glioma stem cells (GSCs), RBM12 recruits ALKBH5 to remove m6A from SLC7A5 transcripts, thereby enhancing mRNA stability, which elevates large neutral amino acid (LNAA) levels and activates mTORC1, promoting GSC proliferation, self‐renewal, and tumor growth.
Hong Lei, Wenlong Luo, Shu Zhou, Lihao Wan, Peng Ling, Zhihua Huang, Zhihua Qian, Chenfei Lu, Mengyue Guo, Zhen Xue, Jun Qin, Ningwei Zhao, Jianghong Man, Wenchao Zhou, Zhiqiang Dong, Shutong Xu, Zhipeng Zhou, Xiuxing Wang, Weiwei Tao   +18 more
wiley   +1 more source

Advancing the Design of High‐Efficiency Printable Hole‐Conductor‐Free Mesoscopic Perovskite Solar Cells Through Machine Learning

Advanced Science, EarlyView.
Based on the largest printable mesoscopic perovskite solar cells database we established, stacking model achieved precise PCE prediction (R2 = 0.73, MAE = 2.18%). Multiple experiments verified the accuracy of the model, which guided the fabrication of high‐PCE devices with an efficiency of 19.36%.
Hao Meng, Jingzi Zhang, Xu Zhu, Yuelin Wang, Antai Yang, Kailong Hu, Chengquan Zhong, Jiakai Liu, Menghan Dun, Xi Lin   +9 more
wiley   +1 more source

Cerium Nanoparticle‐Mediated Inhibition of the NSUN2/m5C Axis Suppresses Synovial Aggression in Rheumatoid Arthritis

Advanced Science, EarlyView.
A novel epitranscriptomic mechanism in rheumatoid arthritis is uncovered: NSUN2 promotes disease via m5C‐dependent stabilization of ICMT mRNA, fueling the migration and invasion of pathogenic RA FLS. Targeting this axis with engineered nanoparticles (Ce/SAA NPs) effectively inhibits disease progression, presenting a precise therapeutic strategy ...
Ruiru Li, Simin Chen, Huijuan Hu, Shiyao Wu, Jingnan Wang, Kai Sun, Chenxi Peng, Suling Liu, Shuoyang Zhang, Yu Kuang, Wei Chen, Qian Qiu, Liuqin Liang, Yu Wen, Hanshi Xu, Youjun Xiao   +15 more
wiley   +1 more source

Influence of SNP mutations in FTO and LEP genes on body mass in bovine populations

Acta Agriculturae Slovenica, 2016
Body mass gain in a certain time period is one of the most important parameters in beef production. Some candidate genes, which have major impact on growth traits, are known from the literature, notably among them the FTO (fat mass and obesity-associated)
Iva ČERNOŠA, Žan PIRC, Andrej RENČELJ   +2 more
doaj   +1 more source

FTO – A Common Genetic Basis for Obesity and Cancer

Frontiers in Genetics, 2020
In recent years, the prevalence of obesity and cancer have been rising. Since this poses a serious threat to human health, the relationship between the two has attracted much attention.
Ning Lan, Ning Lan, Ning Lan, Ying Lu, Ying Lu, Ying Lu, Yigan Zhang, Yigan Zhang, Yigan Zhang, Shuangshuang Pu, Huaze Xi, Xin Nie, Jing Liu, Wenzhen Yuan, Wenzhen Yuan, Wenzhen Yuan   +15 more
doaj   +1 more source

Association of single nucleotide polymorphisms in the fatty acid synthase, LOC514211, and fat mass and obesity-associated genes with milk traits in Indonesian-Holstein dairy cattle [PDF]

Veterinary World, 2019
Aim: The study aimed to identify fatty acid synthase (FASN), LOC514211, and fat mass and obesity-associated (FTO) gene polymorphisms and to investigate their associations with milk traits in an Indonesian-Holstein dairy cow population.
Amalia Puji Rahayu, Tety Hartatik, Agung Purnomoadi, Edy Kurnianto   +3 more
doaj   +1 more source

FTO Prevents Thyroid Cancer Progression by SLC7A11 m6A Methylation in a Ferroptosis-Dependent Manner

Frontiers in Endocrinology, 2022
N6 methyladenosine (m6A) modification serves as a novel epigenetic regulatory mechanism that is heavily implicated in the heredity of tumors. Meanwhile, fat mass and obesity-associated protein (FTO) has the potential to affect the regulation of m6A ...
Fei-Hong Ji, Xing-Hao Fu, Guo-Quan Li, Qi He, Xin-Guang Qiu   +4 more
doaj   +1 more source

WDR72 Promotes Neuroblastoma Stemness and Progression by Sequestering TRIM31‐Mediated Degradation of CBX8

Advanced Science, EarlyView.
This study unveiled that METTL14 mediates m6A modification of WDR72 mRNA to stabilize and enhance WDR72 expression, which disrupts TRIM31‐mediated ubiquitination of CBX8 protein and retards its degradation, finally the elevated CBX8 contributes to tumor stemness.
Huijuan Zeng, Zijie Ye, Manna Zheng, Jing Pan, Tianbao Tan, Jiliang Yang, Jiahao Li, Zhang Zhao, Tianzhu Long, Liyu Zhang, Gautam Sethi, Tianyou Yang, Chao Hu, Yan Zou   +13 more
wiley   +1 more source

In depth analysis of the association of FTO SNP (rs9939609) with the expression of classical phenotype of PCOS: a Sri Lankan study

BMC Medical Genetics, 2020
Background PCOS is a common disorder of women due to genetic, endocrine and environmental effects that manifests from puberty. The rs9939609 variant of fat mass and obesity associated (FTO) gene is linked to metabolic derangement in PCOS.
Umayal Branavan, Sulochana Wijesundera, Vishvanath Chandrasekaran, Carukshi Arambepola, Chandrika Wijeyaratne   +4 more
doaj   +1 more source