Results 51 to 60 of about 7,322,114 (249)
Impact of variation at the FTO locus on milk fat yield in Holstein dairy cattle. [PDF]
PLoS ONE, 2013 This study explores the biological role of the Fat Mass and Obesity associated (FTO) gene locus on milk composition in German Holstein cattle. Since FTO controls energy homeostasis and expenditure and the FTO locus has repeatedly shown association with ...
Lea G Zielke +5 more
doaj +1 more source
A mouse model for the metabolic effects of the human fat mass and obesity associated FTO gene.
PLoS Genetics, 2009 Human FTO gene variants are associated with body mass index and type 2 diabetes. Because the obesity-associated SNPs are intronic, it is unclear whether changes in FTO expression or splicing are the cause of obesity or if regulatory elements within ...
Chris Church +12 more
doaj +1 more source
The Decay of Disease Association with Declining Linkage Disequilibrium: A Fine Mapping Theorem [PDF]
, 2016 Several important and fundamental aspects of disease genetics models have yet to be described. One such property is the relationship of disease association statistics at a marker site closely linked to a disease causing site.
Bansal, Naveen K. +8 more
core +3 more sources
Indian Heart Journal, 2017 The various studies have examined the relationship between FTO gene expression and macronutrients levels. In order to obtain better viewpoint from this interactions, all of existing studies were reviewed systematically.
Saeid Doaei +4 more
doaj +1 more source
Genetic Variation at the FTO Locus Influences RBL2 Gene Expression [PDF]
Diabetes, 2009 OBJECTIVE Genome-wide association studies that compare the statistical association between thousands of DNA variations and a human trait have detected 958 loci across 127 different diseases and traits. However, these statistical associations only provide evidence for genomic regions likely to harbor a causal gene(s)
Jowett, J. +10 more
openaire +3 more sources
Relationship between the hsa miR 150-5p and FTO gene expression in white subcutaneous adipose tissue with overweight/obesity, lipid profile and glycemia [PDF]
Anais da Academia Brasileira de Ciências, 2020 The overweight population is growing in the world, and the search for obesity-associated mechanisms is important for a better understanding of this disease. Few studies with the FTO gene and miRs show how they associate to obesity and how they can impact
VITOR N. MORAES +6 more
doaj +1 more source
Lifestyle factors modify obesity risk linked to PPARG2 and FTO variants in an elderly population: a cross-sectional analysis in the SUN Project. [PDF]
, 2012 Genetic factors may interact with lifestyle factors to modify obesity risk. FTO and PPARG2 are relevant obesogenes. Our aim was to explore the effect of Pro12Ala (rs1801282) of PPARG2 and rs9939609 of FTO on obesity risk and to examine their interaction ...
Galbete, C. (Cecilia) +5 more
core +1 more source
Gene Variants Are Associated with PCOS Susceptibility and Hyperandrogenemia in Young Korean Women [PDF]
Diabetes & Metabolism Journal, 2014 BackgroundThe fat mass and obesity-associated (FTO) gene is associated with obesity and type 2 diabetes mellitus. Obesity and insulin resistance are also common features of polycystic ovary syndrome (PCOS).
Do Kyeong Song +4 more
doaj +1 more source
International Journal of Food Science and Nutrition, 2020 The aim of the study was to investigate whether lifestyle factors modify the association between fat mass and obesity-associated (FTO) gene single nucleotide polymorphisms (SNPs) and obesity in a Turkish population.
K. Isgin-Atici +12 more
semanticscholar +1 more source
PLoS ONE, 2018 BackgroundSingle-nucleotide polymorphisms (SNPs), which are located in the first intron of the FTO gene, are reported to be associated with body weight and the body mass index (BMI).
Naser Kalantari +10 more
doaj +1 more source