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Genetic variants and the metabolic syndrome: a systematic review [PDF]
, 2011 Several candidate gene studies on the metabolic syndrome (MetS) have been conducted. However, for most single nucleotide polymorphisms (SNPs) no systematic review on their association with MetS exists.
Boer, J.M., Feskens, E.J.M., Povel, C.M.
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Association of FTO gene with obesity in Polish schoolchildren [PDF]
Anthropological Review, 2014 The goal of the study was verification of fat mass and obesity-associated (FTO) gene polymorphisms as significant risk factors of obesity in the population of Polish children. Body mass index (BMI) and DNA were evaluated, where DNA was extracted from saliva, collected from 213 children at the age of 6–13 years. DNA was genotyped by PCR ...
Sitek, A. +5 more
openaire +3 more sources
, 2023 N6-methyladenosine (m6A) regulates fat development in many ways. Low intramuscular fat (IMF) in rabbit meat seriously affects consumption. In order to improve meat quality, we explored the law of IMF deposition. FTO could increase the expression of APMAP
Lin Yu +3 more
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Effect of FTO Expression and Polymorphism on Fat Deposition in Suzhong Pigs [PDF]
Asian-Australasian Journal of Animal Sciences, 2013 Fat mass and obesity associated gene (FTO) plays an important role in appetite control and energy consumption in human and mice. In order to examine FTO expression influence on fat deposition in Suzhong pigs, FTO mRNA expression was detected in 16 ...
Yanfeng Fu, Lan Li, Shouwen Ren
doaj +1 more source
A mouse model for the metabolic effects of the human fat mass and obesity associated FTO gene.
PLoS Genetics, 2009 Human FTO gene variants are associated with body mass index and type 2 diabetes. Because the obesity-associated SNPs are intronic, it is unclear whether changes in FTO expression or splicing are the cause of obesity or if regulatory elements within ...
Chris Church +12 more
doaj +1 more source
Neurobeachin, a Regulator of Synaptic Protein Targeting, Is Associated with Body Fat Mass and Feeding Behavior in Mice and Body-Mass Index in Humans [PDF]
, 2012 Neurobeachin (Nbea) regulates neuronal membrane protein trafficking and is required for the development and functioning of central and neuromuscular synapses. In homozygous knockout (KO) mice, Nbea deficiency causes perinatal death.
Schiöth, H. +163 more
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Impact of variation at the FTO locus on milk fat yield in Holstein dairy cattle. [PDF]
PLoS ONE, 2013 This study explores the biological role of the Fat Mass and Obesity associated (FTO) gene locus on milk composition in German Holstein cattle. Since FTO controls energy homeostasis and expenditure and the FTO locus has repeatedly shown association with ...
Lea G Zielke +5 more
doaj +1 more source
Relationship between the hsa miR 150-5p and FTO gene expression in white subcutaneous adipose tissue with overweight/obesity, lipid profile and glycemia [PDF]
Anais da Academia Brasileira de Ciências, 2020 The overweight population is growing in the world, and the search for obesity-associated mechanisms is important for a better understanding of this disease. Few studies with the FTO gene and miRs show how they associate to obesity and how they can impact
VITOR N. MORAES +6 more
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PLoS ONE, 2018 BackgroundSingle-nucleotide polymorphisms (SNPs), which are located in the first intron of the FTO gene, are reported to be associated with body weight and the body mass index (BMI).
Naser Kalantari +10 more
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PLoS ONE, 2010 Sequence variants in the first intron of FTO are strongly associated with human obesity and human carriers of the risk alleles show evidence for increased appetite and food intake. Mice globally lacking Fto display a complex phenotype characterised by both increased energy expenditure and increased food intake.
Tung, Yi-Chun Loraine +6 more
openaire +6 more sources