Results 71 to 80 of about 2,549,001 (246)
AL398, A Novel NSUN6 Inhibitor, Attenuates Epithelial‐Mesenchymal Transition and Metastasis in Endometrial Cancer by Abrogating m5C‐Dependent Stabilization of Snail mRNA
Advanced Science, EarlyView.Proposed molecular mechanism: NSUN6 catalyzes m5C methylation on Snail mRNA to enhance its stability, leading to Snail upregulation and EMT promotion. The first‐in‐class inhibitor AL398 suppresses endometrial cancer metastasis by targeting the NSUN6‐m5C‐Snail. axis. ABSTRACT
Endometrial cancer (EC) constitutes a leading gynecologic malignancy for which Xiangzhuan Zhao, Linlin Yang, Huanxiang Chen, Chenfeng Guo, Hongshen Lu, Ying Zhu, Xuanzhi Wang, Yang Li, Ruike Zhang, Zichong Huang, Yifang Chen, Keyu Jin, Zeduo Xu, Lingxiu Meng, Longfeng Zhang, Yuanyuan Han, Yicong Yan, Qiaozhen Kang, Junhu Wan, Hongyang Liu +19 morewiley +1 more sourceRegulation ofFto/Ftmgene expression in mice and humans [PDF]
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 2008 Two recent, large whole-genome association studies (GWAS) in European populations have associated a ∼47-kb region that contains part of the FTO gene with high body mass index (BMI). The functions of FTO and adjacent FTM in human biology are not clear.Stratigopoulos, G, Padilla, S, LeDuc, C, Watson, E, Hattersley, A, McCarthy, M, Zeltser, L, Chung, W, Leibel, R +8 moreopenaire +2 more sourcesACSL4‐Dependent Lysosomal Lipid Peroxidation Links WTAP‐Mediated m6A Modification to Intervertebral Disc Degeneration
Advanced Science, EarlyView.IL‐1β upregulates the protein level of WTAP, which promotes the m6A modification of ACSL4 mRNA in an IGF2BP2‐dependent manner, thereby enhancing its stability. The increased ACSL4 drives lipid peroxidation, leading to lysosomal membrane permeabilization (LMP) and impaired mitophagy, which collectively accelerate intervertebral disc degeneration (IVDD). Shu Jia, Xu Gao, Laimin Zhu, Haixia Song, Jing Wu, Shang Chen, Sheng Gao, Lu Zhang, Chunyang Meng +8 morewiley +1 more sourcePolymorphisms in FTO and near TMEM18 associate with type 2 diabetes and predispose to younger age at diagnosis of diabetes
, 2013 Variations in the FTO gene and near the TMEM18 gene are risk factors for common form of obesity, but have also been linked with type 2 diabetes (T2D). Our aim was to investigate the contribution of these variants to risk of T2D in a population in Latvia. Geldnere, Kristine, Zaharenko, Linda, Pirags, Valdis, Rovite, Vita,, Nikitina-Zake, Liene, Peculis, Raitis, Fridmanis, Davids,, Schiöth, Helgi B.,, Klovins, Janis,, Kalnina, Ineta,, Jacobsson, Josefin A.,, Almén, Markus Sällman,, Vaivade, Iveta +12 morecore +1 more sourceMeta-Analysis of the INSIG2 Association with Obesity Including 74,345 Individuals [PDF]
, 2009 The INSIG2 rs7566605 polymorphism was identified for obesity (BMI >= 30 kg/m(2)) in one of the first genome-wide association studies, but replications were inconsistent.Kronenberg, F, Hoehe Margret R., Engert, James C, Shengxu Li, Mohlke, Karen L, Luchner, A., Hoehe, Margret R., Paulweber, Bernhard, Hubacek, JA, Jitender Kumar, Hebebrand, J., Mohlke Karen L., Allison, David B., Hegele, RA, McCarthy, Mark I, Ardlie, K, Waterworth Dawn, Hegele, Robert A., Järvelin Marjo-Riita, Yusuf Salim, Qi, L., Mohlke, Karen L., Henry Völzke, Engert James C., Lange Christoph, Margret R Hoehe, Völzke Henry, Bjerregaard Peter, Heid, Iris M., Ruth J. F. Loos, Wichmann, H.-E., Leslie A Lange, Joel N Hirschhorn, Andreas Luchner, Illig Thomas, Vimaleswaran, Karani S., Johannes Hebebrand, Kaakinen, M, Vimaleswaran, Karani Santhanakrishnan, Humphries, S.E., Hu, F.B., Qi Lu, Kaakinen, Marika, Krude Heiko, Froguel Philippe, Frances, F, Hirschhorn, Joel, Barbara Kollerits, Heid Iris M., Langer Birgit, Cooper, Jackie A., Bouchard Claude, Li, S., Qi, Lu, Hu, Frank B, Mohlke, K.L., Karani S Vimaleswaran, Sonia S Anand, Vimaleswaran, K.S., Steve E. Humphries, Sengupta, S., Engert, J.C., Boeing Heiner, Hunt, SC, Christoph Lange, Yusuf, S., Loos, Ruth J F, Hubacek Jaroslav A., Nan Laird, Lindgren, Cecilia, Rosskopf Dieter, Humphries, Steve E, Hoehe, M.R., Corella, Dolores, Corella Dolores, Kumar Jitender, Heid, I.M., Kronenberg, Florian, Engert, James C., Mooser, Vincent, Lange Leslie A., Li Shengxu, Hinney, A., Marika Kaakinen, Lu Qi, Suk, A., Nguyen Thuy Trang, Dieter Rosskopf, Eva Fisher, Lange, LA, Biebermann, Heike, Perusse, L, Wichmann, H-Erich, Jarvelin, Marjo-Riita, Li, SX, Corella, D., Ardlie, Kristin, Hu, Frank B., Heid, IM, Lange, C, Unnur Thorsteinsdottir, Wichmann, H.-Erich, Wichmann, H-E, Adamkova, V, Peter Bjerregaard, Schreiber Stefan, Qi, L, Nguyen, Thuy Trang, Wareham, Nicholas J, Frances, Francesc, Marjo-Riita Järvelin, Dina, C., Cornelia Huth, Helen N Lyon, Anand, Sonia S., Schreiber, Stefan, Hubacek, Jaroslav A, Claude Bouchard, Laird, N., Anand, SS, Louis Perusse, David Meyre, Mark I. Mccarthy, Ardlie Kristin, Laird, Nan, Jarvelin, M.R., Heid, Iris M, Hebebrand, Johannes, Schreiber, S., Hegele, R.A., Perusse, Louis, Leslie A. Lange, Gudmar Thorleifsson, Kollerits, Barbara, Hubácek, J.A., Kollerits, B, Jarvelin, M-R, Karen L Mohlke, Hunt, S.C., Jaroslav A Hubacek, Fisher Eva, Cooper Jackie A., Fisher, E, Florian Kronenberg, Salim Yusuf, Nguyen, TT, Ciullo, Marina, Thorsteinsdottir Unnur, Lindgren Cecilia, Hu, FB, Heiko Krude, Suk, A, McCarthy, MI, Völzke, Henry, Suk Anita, Lindgren, C, McCarthy Mark I., Vera Adamkova, Wichmann, HE, Thorsteinsdottir, Unnur, Paulweber Bernhard, Hunt Steven C., Thomas Illig, Rankinen, T., Nebel, A, Langer, Birgit, Luchner, Andreas, Hirschhorn Joel N., Lyon, Helen N., Sengupta, Shantanu, Marina Ciullo, Cecilia Lindgren, Meyre, David, Huth, C., McCarthy, Mark I., Krude, H, Lyon, HN, Volzke, H, Kumar, J., Kronenberg, F., Jaroslav A. Hubacek, Mooser Vincent, Johannes Hebebr, Paulweber, B., Hegele, Robert A, Boeing, Heiner, Thorleifsson, G, Li, S, Ciullo Marina, Kumar, J, Lyon, Helen N, Illig, T, James C. Engert, Ciullo, M., Wareham, N.J., Kumar, Jitender, Vimaleswaran, Karani S, Luchner, A, Thorleifsson Gudmar, Frank B. Hu, Sengupta, S, Fisher, Eva, Nicholas J Wareham, Paulweber, B, Schreiber, S, Rankinen Tuomo, Heike Biebermann, Karani S. Vimaleswaran, Hubacek, Jaroslav A., Steve E Humphries, Kollerits Barbara, Nicholas J. Wareham, Hinney, A, Vincent Mooser, Nguyen, T.T., Heiner Boeing, Robert A Hegele, Loos, Ruth J. F., Christian Dina, Dina Christian, Mooser, V, Corella, D, Langer, B, Illig, T., Hunt, Steven C, Rosskopf, Dieter, Fisher, E., Anand, S.S., Vimaleswaran, KS, Huth Cornelia, Hirschhorn, J.N., Loos, RJF, Bouchard, C., Cooper, J.A., Wareham Nicholas J., Rankinen, T, Bjerregaard, P., Rosskopf, D., Huth, Cornelia, James C Engert, Kaakinen Marika, Völzke, H., Laird, N, Kaakinen, M., Hebebrand, J, Boeing, H, Dawn Waterworth, Iris M Heid, Birgit Langer, Voelzke, H, Francès, F., H-Erich Wichmann, Hebebrand Johannes, Meyre David, Mooser, V., Anita Suk, Thorsteinsdottir, U., Francès Francesc, Sorice, Rossella, Francesc Francès, Anke Hinney, Hinney Anke, Perusse, L., Meyre, D, Hu Frank B., Rosskopf, D, Lyon Helen N., Nebel Almut, Joel N, Lyon, H.N., Hinney, Anke, Lange, Leslie A., Adamkova, V., Biebermann, H., Bjerregaard, P, Iris M. Heid, Mohlke, KL, Hunt, Steven C., Cooper, JA, Robert A. Hegele, Nebel, Almut, Tuomo Rankinen, Margret R. Hoehe, Bernhard Paulweber, Loos, RJ, Waterworth, Dawn, Thorleifsson, G., Bjerregaard, Peter, Loos Ruth J. F., Sengupta Shantanu, Wareham, NJ, Krude, H., Waterworth, D, Philippe Froguel, Waterworth, D., Biebermann, H, Wichmann, Heinz-Erich, Dolores Corella, Thorleifsson, Gudmar, Adamkova Vera, Thorsteinsdottir, U, Thuy Trang Nguyen, McCarthy, M.I., Ruth J F Loos, Kollerits, B., Anand, Sonia S, Jarvelin, MR, Langer, B., Yusuf, S, Humphries, SE, Almut Nebel, Ciullo, M, Lange, Christoph, Jackie A. Cooper, Steven C. Hunt, Hirschhorn, Joel N., Bouchard, Claude, Lange, C., Kristin Ardlie, Stefan Schreiber, Sorice, R., Ardlie, K., Wareham, Nicholas J., Laird Nan, Loos, R.J.F., Lange, L.A., Kronenberg Florian, Wichmann H.-Erich, Huth, C, Dina, Christian, Engert, JC, Dina, C, Shantanu Sengupta, Froguel, Philippe, Perusse Louis, Rossella Sorice, Bouchard, C, Suk, Anita, Steven C Hunt, Hoehe, Margret R, Lindgren, C., Mark I McCarthy, Cooper, Jackie A, Illig, Thomas, Sorice, R, Hirschhorn, Joel N, Lange, Leslie A, Hu, Frank, Voelzke, Henry, Yusuf, Salim, Li, Shengxu, Luchner Andreas, Nebel, A., Hirschhorn, JN, Adamkova, Vera, Hoehe, MR, Anand Sonia S., H. -erich Wichmann, Bjerregaard, Peter; id_orcid, Humphries Steve E., Jackie A Cooper, Boeing, H., Froguel, P., Sonia S, Krude, Heiko, Sorice Rossella, Biebermann Heike, Meyre, D., Hegele Robert A., Humphries, Steve E., Frank B Hu, Rankinen, Tuomo, Froguel, P, Vimaleswaran Karani S. +373 morecore +1 more sourceIntegrated O2 and H2 Gas Therapy via Microneedle‐Assisted Photocatalytic Water Splitting for Accelerating Diabetic Full‐Thickness Skin Wound Healing
Advanced Science, EarlyView.A concept of integrated O2 and H2 gas therapy is achieved using a gas‐producing material. PMP nanoparticles, fabricated from platinum, MIL‐101(Fe)‐NH2, and phosphotungstic acid, are integrated into bilayer gelatin methacryloyl microneedles for transdermal delivery. These microneedles enable integrated O2 and H2 gas therapy and promote wound healing via Zesheng Chen, Yanchao Yu, Xingyuan Xiao, Wenwen Cheng, Ye Yang, Zhengyao Zhang, Wang Wang, Zhijun Zhou, Weikang Hu, Xiaolong Wang, Bing Li, Kwang Leong Choy, Yun Chen, Zijian Wang +13 morewiley +1 more sourceFTO – A Common Genetic Basis for Obesity and Cancer
Frontiers in Genetics, 2020 In recent years, the prevalence of obesity and cancer have been rising. Since this poses a serious threat to human health, the relationship between the two has attracted much attention.Ning Lan, Ning Lan, Ning Lan, Ying Lu, Ying Lu, Ying Lu, Yigan Zhang, Yigan Zhang, Yigan Zhang, Shuangshuang Pu, Huaze Xi, Xin Nie, Jing Liu, Wenzhen Yuan, Wenzhen Yuan, Wenzhen Yuan +15 moredoaj +1 more sourceRestoration of m6A‐Modified circPSMB1 Suppresses Chordoma Progression and Enables Local Nanotherapeutic Intervention
Advanced Science, EarlyView.An m6A‐modified circRNA, circPSMB1, is identified as a tumor suppressor in chordoma. METTL3‐dependent m6A promotes circPSMB1 interaction with HNRNPA2B1, limiting c‐MYC expression and malignant progression. An injectable HMnO2‐based nanohydrogel enables local circPSMB1 delivery and tumor microenvironment‐responsive therapy, offering a promising strategy Yingchuang Tang, Liang Qiu, Xingbang Ruan, Yihan Shi, Ye Wang, Hanwen Li, Kai Zhang, Kangwu Chen +7 morewiley +1 more source
