Results 91 to 100 of about 2,549,001 (246)
Adiposity-Related Heterogeneity in Patterns of Type 2 Diabetes Susceptibility Observed in Genome-Wide Association Data [PDF]
, 2009 OBJECTIVE-This study examined how differences in the BMI distribution of type 2 diabetic case subjects affected genome-wide patterns of type 2 diabetes, association mid considered the implications for the etiological heterogeneity of type 2 diabetes ...Timpson, NJ, David P. Strachan, Weedon, Michael N., Weedon, MN, Nicholas J. Timpson, Rayner, NW, Morris, Andrew D., Zeggini, Eleftheria, Mark Walker, Alex S.F. Doney, Doney, ASF, Palmer, Colin N A, Timothy M. Frayling, Strachan, David P., Hitman, Graham A., Lindgren, Cecilia M., Hattersley, Andrew T., Hitman, GA, Lindgren, CM, Randall, Joshua, Doney, Alex S. F.; id_orcid, Graham A. Hitman, Andrew T. Hattersley, Walker, Mark, Palmer, CN, Hattersley, AT, Rayner, N. William, McCarthy, MI, Timpson, Nicholas J., Michael N. Weedon, Willem H. Ouwehand, Palmer, CNA, Walker, M, Andrew D. Morris, Doney, Alex S F, N. William Rayner, Lindgren, Cecilia, Randall, J, Mark I. McCarthy, Frayling, Timothy M., Strachan, DP, Morris, AD, Cecilia M. Lindgren, Doney, AS, Joshua Randall, McCarthy, Mark I., Zeggini, E, Eleftheria Zeggini, Ouwehand, WH, Pamler, CAN, Ouwehand, Willem H., Colin N.A. Palmer, Frayling, TM, Palmer, Colin N. A.; id_orcid +53 morecore +1 more sourceLactate Signal: Modulator of Cellular Energy Production and Anabolism
Advanced Science, EarlyView.Compartmentalized lactate signaling provides a spatial framework for understanding how lactate‐rich states are generated, transported, sensed, and translated into biological outputs. This Review integrates extracellular, cytosolic, mitochondrial‐associated, and nuclear lactate mechanisms to explain how lactate shapes metabolic adaptation, immune ...Han Wang, Si‐Yuan Yang, Wei Xuwiley +1 more sourceβ‐Adducin Restrains PLA2G4A‐Dependent Lysosomal Membrane Permeabilization and Neuronal Death in Ischemic Stroke
Advanced Science, EarlyView.This study identifies β‐adducin as a regulator of lysosomal integrity in ischemic neurons. Ischemia‐associated FTO loss increases m6A modification and destabilizes Add2 mRNA, reducing β‐adducin expression and promoting PLA2G4A accumulation at lysosomes.Hui‐qin Li, Pin‐yi Liu, Dan Wu, Fei‐yu Ma, Yi Bai, Sheng‐nan Xia, Hai‐yan Yang, Xin‐yu Bao, Yun Xu, Xiang Cao +9 morewiley +1 more sourceGenome-wide association scan meta-analysis identifies three loci influencing adiposity and fat distribution [PDF]
, 2009 To identify genetic loci influencing central obesity and fat distribution, we performed a meta-analysis of 16 genome-wide association studies (GWAS, N = 38,580) informative for adult waist circumference (WC) and waist–hip ratio (WHR). We selected 26 SNPs Boehnke, M., Silander, K, Munroe, P., Lyon, H.N. (Helen), Lamina, C., Holle, R. (Rolf), Doering, A., Mohlke Karen L., Sanna, Serena, McCarthy, Mark I, Karpe, F, Qi, L., Amin, N. (Najaf), Mangino, M., Ruokonen, A., Bandinelli, S, Franks, P.W., Toshiko Tanaka, Kuusisto, J, Randall, Joshua C, Bonnycastle, LL, Sanna, S., Renström, F. (Frida), Hu, F. B, Anna Nordström, Tiinamaija Tuomi, Silander, K., Forouhi Nita G., Day, I.N.M., Qi Lu, Scott Laura J., Mangino Massimo, Hirschhorn, Joel, Heid Iris M., Qi, Lu, Palmer, CN, Uitterlinden, André G, Groop, L., Forouhi, Nita G., Davey Smith George, Hunter David J., Fischer, G., Barroso, Inês, Cuilin Zhang, Loos, Ruth J F, Hugh Watkins, Lindgren, C. M, Zillikens, M. Carola, Willer, C. J, Davey Smith, George, Stefansson, K, Chambers, John C, Qi, L. (Lu), Randall, J.C., Jacobs, Leonie C, Frayling, Timothy M., Michael R. Erdos, Almgren, P., Waeber Gerard, Caulfield Mark J., Timpson, Nicholas J, Hofman, A., Lu Qi, Vollenweider Peter, Palmer, C.N.A. (Colin), Waterworth, D. (Dawn), Valgerdur Steinthorsdottir, Jarvelin, Marjo-Riitta, Davey Smith, G., Cecilia M Lindgren, McArdle, W. L, Kong, A., Nordström, P, Herrera, B.M. (Blanca), Wichmann, H-E, Manjinder S Sandhu, Qi, L, Markku Laakso, Estrada, K, Smith, GD, Rivadeneira, F, Bergman, R.N., Almgren, Peter, Gonçalo R Abecasis, Uitterlinden, A. G, Strachan, David P., Salomaa, Veikko, Timothy D. Spector, Bergman, Richard N., Collins, Francis S, Gieger Christian, Laakso, M, Payne Felicity, Hofman Albert, Lori L. Bonnycastle, Cherkas, Lynn, Blanca M. Herrera, Hattersley, A. T, Peter Nordström, Fischer, G, McCarthy, MI, Thorleifsson,Gudmar, Schlessinger, D. (David), Zhang, W., Andrew D. Morris, Doney, Alex S F, Morris, Andrew, Thomas Illig, Kong Augustine, Crawford, G., Ruokonen, A. (Aimo), Fischer, G. (Guido), Waterworth, Dawn M., John C. Chambers, Renstroem, Frida, Day, I.N.M. (Ian), Stringham, Heather M., Scuteri, Angelo, Morris, AD, Yurii S. Aulchenko, Doney, AS, Morris, AP, Guiducci Candace, Mark J Caulfield, Caulfield, M.J., Kooner, J.S., Hadley, D., Herrera, Blanca M., Lyon, HN, Fernando Rivadeneira, Holloway, J.W., Jaakko Tuomilehto, Debbie A Lawlor, Gieger, C. (Christian), George Davey Smith, Lachlan Coin, Lyon, Helen N, Wareham, N.J., Weedon, Michael N., Nicholas J. Timpson, Mangino, M, Kooner, Jaspal S, Zillikens, M. C, Sandhu, M.S. (Manjinder), Morris, A. D, Almgren, P, Yuan, X., Morris, A. P, Nicholas J. Wareham, Karen Jameson, Lim, N., Chanock, S.J., Loos, Ruth J. F., Stringham, H.M. (Heather), Doney, Alex SF, Illig, T., Zhang, WH, Swift, A.J. (Amy), Hunter, DJ, Holloway, JW, McCarthy, Mark, Colin N A Palmer, Loos, RJF, Havulinna, A.S. (Aki), Groves, C.J., Collins, F.S., Jackson, A.U., Andrew P Morris, Estrada, K., Swift, A. J, Drong Alexander, Ian N M Day, Iris M Heid, Sanna Serena, Morris, A.P. (Andrew), Waterworth, DM, Ruokonen, Aimo, Ferrucci Luigi, Yuan Xin, Aulchenko, Y.S., Frayling, T.M. (Timothy), Joel N. Hirschhorn, Iris M. Heid, Kooner, J.S. (Jaspal), Cornelia M. van Duijn, Uitterlinden, André G., Almgren, P. (Peter), Wellcome Trust Case Control Consortium, Consortium, GIANT, Swift Amy J., Hirschhorn, J.N. (Joel), Ruokonen Aimo, Jacobs Leonie C., Bergman, RN, Nordström, A, Waterworth, Dawn M, Herrera, BM, Jackson Anne U., Thorsteinsdottir, U, M Carola Zillikens, Mark I. McCarthy for the GIANT consortium, Ruth J F Loos, Jarvelin, MR, Lamina Claudia, Jing Hua Zhao, Salomaa, V. (Veikko), van Duijn, Cornelia M., McArdle, W.L. (Wendy), Groves Christopher J., Hadley, D. (David), Laura J Scott, Thorsteinsdottir, U. (Unnur), Luan, J., Groop, L. (Leif), Hugh Watkins for the PROCARDIS consortia, Debbie A. Lawlor, Walters, G.B., Grundy, S, Jackson, Anne U, Steinthorsdottir, V. (Valgerdur), Walters, G. Bragi, Heid, I. M, Crawford Gabriel, Aki S Havulinna, Collins, FS, Silander Kaisa, Ruokonen, A, Randall, J.C. (Joshua), Zhao, JH, Franks, P.W. (Paul), Kuusisto, J. (Johanna), Laakso, M. (Markku), Palmer, CNA, Amin Najaf, Oostra, Ben A, Doney, A.S., Schlessinger, David, Illig, Thomas, Hirschhorn, Joel N, David J. Hunter, Salomaa Veikko, Day Ian N. M., Hu, Frank, Tuomi, T., Vollenweider, P, Laakso, Markku, Ebrahim, S. (Shanil), Oostra Ben A., Jaspal S. Kooner, Yuan, Xin, Lathrop, G Mark, Thomas Meitinger, Lamina, Claudia, Hadley, David, Barroso, I.E. (Inês), Soranzo Nicole, Elliott, P., Dawn M. Waterworth, Andrew P. Morris, Laitinen, J., Drong, A, Franks, PW, Nordström Anna, Claudia Lamina, Helen N. Lyon, Luan, JA, Suzannah J Bumpstead, McCarthy, M.I. (Mark), Aimo Ruokonen, Tanaka, T, Marjo-Riitta Jarvelin, Spector, Timothy D, Aulchenko, Y.S. (Yurii), Francis S. Collins, Lakatta, E., Richard N Bergman, Luan, Jian'an, Panos Deloukas, Dawn M Waterworth, Stringham, Heather M, Morris, Andrew D., Ebrahim, S, Najaf Amin, Allison, David B., Cons, WTCC, Doney, ASF, Walters, G Bragi, Caulfield, Mark J., Procardis Consortia, Tuomilehto, J., Swift, Amy J, Chanock, S. J, Ebrahim, Shah, Erdos, M. R, Peter Chines, Cherkas, L., Sandhu, Manjinder S., Deloukas, P, Guiducci, Candace, Cooper Cyrus, Paul W. Franks, Strachan David P., Hunter, D.J. (David), Crawford, G. (Gabe), Lathrop, G. Mark, Song, K. (Kijoung), Serena Sanna, Holle, Rolf, Doering, A, Estrada Karol, Heid, I.M. (Iris), Michael R Erdos, Salomaa, V., Stringham Heather M., Bumpstead Suzannah J., Uda, M, Ian N. M. Day, Mohlke, K.L., Hunter, D.J., Guiducci, C, Stringham, H. M, Bennett, A.J., Renström Frida, Scheet, P., Narisu, Narisu, Song, K, Vollenweider, P., Waeber, G. (Gérard), Collins, F.S. (Francis), Bennett, Amanda J, Xin Yuan, Leena Peltonen, David J Hunter, Scuteri Angelo, Meitinger, T., Day, Ian N. M., Grallert, H., Jacqueline C. M. Witteman, Kari Stefansson, Mario A. Morken, Steinthorsdottir, V., Rivadeneira Fernando, Frida Renström, Hu, Frank B., Gonçalo R. Abecasis, Mohlke, K.L. (Karen), Karol Estrada, Lindgren, Cecilia M, Inga Prokopenko, David P. Strachan, Joshua C Randall, Wareham, Nicholas J, Lawlor Debbie A., Mario A Morken, Döring, A., Smith, G.D., Chines, P, Barroso, I., Helen N Lyon, Timothy M Frayling, G Mark Lathrop, Chanock, Stephen J., Doering, Angela, Cristen J. Willer, Palmer, Colin N A, Day, I. N. M, Heid, Iris M, Lathrop, G.M. (Mark), Hattersley, A.T., McCarthy, M. I, Barroso, IS, Jameson, K. (Karen), Guiducci, C. (Candace), Samani, N.J., Havulinna, A. S, Morris Andrew D., Jarvelin, M.-R. (Marjo-Riitta), Coin, L. (Lachlan), Willer, C.J. (Cristen), Scott, Laura J, Joshua C. Randall, Soranzo, N., Peltonen, Leena, Alexander Drong, John F. Peden, Waeber, G., Lawlor, D.A., Hu, FB, Holloway John W., Frayling, T. M, Blanca M Herrera, Boehnke, Michael, Walters, G.B. (Bragi), Havulinna Aki S., Wichmann, HE, Jameson Karen, Lindgren, C.M. (Cecilia), Heather M. Stringham, Franks Paul W., Steinthorsdottir, Valgerdur, Watkins, H. (Hugh), Silander, Kaisa, Kooner, J. S, Jousilahti, P, Pekka Jousilahti, Gerard Waeber, Spector, Timothy D., McArdle Wendy L., Tuomi, T. (Tiinamaija), Tanaka, T. (Toshiko), Tuomi Tiinamaija, Karpe, F., Candace Guiducci, Jing, H.Z., Estrada Gil, K. (Karol), Frayling, Timothy M, Mooser Vincent, Lakatta Edward, Lyon, H. N, Leonie C Jacobs, Erdos, M.R. (Michael), Abecasis, Gonçalo R, David Schlessinger, Illig, T, Bandinelli, S. (Stefania), Barroso, I.S., Walters G. Bragi, Munroe Patricia, Wendy L. McArdle, Aulchenko, Yurii S., Nilesh J. Samani, Peden, John F., Cristen J Willer, Weedon Michael N., Veikko Salomaa, Prokopenko, I, Payne, Felicity, Collins Francis S., Chambers, J.C., Holloway, J.W. (John), Day, I.N., Holle, R., Samani Nilesh J., Hugh Watkins, D.M., Jackson, A.U. (Anne), Amin, N, Stefansson, Kari, Samani, Nilesh J, Peltonen, L. (Leena Johanna), Hattersley, Andrew T, Spector, T.D. (Timothy), Hamsten Anders, Kaisa Silander, Doering, A. (Angela), Collins, F. S, McArdle, W.L., Hirschhorn, J.N., Vollenweider, Peter, Abecasis, G. R, Soranzo, Nicole, Michael N Weedon, Hofman, A. (Albert), Palmer, C.N., Hattersley, AT, Albert Hofman, Elliott, P, Amanda J Bennett, Song Kijoung, Song, K.J., Uitterlinden André G., Randall, Joshua C., Drong, A. (Alexander), Scott, L.J. (Laura), Lindgren Cecilia M., Elizabeth K Speliotes, Bennett Amanda J., Willer, Cristen J, Cooper, C. (Charles), Gieger, Christian, Payne, F. (Felicity), Hu Frank B., Lim Noha, Caulfield, MJ, Van Duijn, C. M, Waterworth, D. M, Bonnycastle, L.L., Nordstrom, P., Gabriel Crawford, Doney, A. S. F, Grundy Scott, Dominiczak, A., Loos, RJ, Kooner, Jaspal S., Kooner, JS, Lamina, C, Forouhi, N. G, Doney, A.S.F. (Alex), Kuusisto, Johanna, Morken, M.A., Chanock, S.J. (Stephen), Thorleifsson, Gudmar, Zhang Weihua, Munroe, P, Witteman, J. C. M, Amin, N., Weedon, MN, Timpson Nicholas J., Oostra, B.A., Luan, J, Watkins, Hugh, Lakatta, Edward, Christian Gieger, Zhao Jing Hua, Morken, M.A. (Mario), Bandinelli Stefania, Bergman, Richard N, Aki S. Havulinna, Nordström Peter, Jacobs, L.C., Morken, Mario A, Lathrop, G.M., Scott, Laura J., Anna Dominiczak, Song, Kijoung, Michael Boehnke, Franks, P. W, Spector, T.D., Lindgren, CM, Loos, R.J.F., Groves, C.J. (Christopher), Zillikens M. Carola, Holle Rolf, Scott, LJ, Bumpstead, S.J., Forouhi, NG, Waeber, G, Aulchenko, Yurii S, Steinthorsdottir Valgerdur, Doney, Alex S. F.; id_orcid, Kuusisto Johanna, Loos, R.J., Andrew T. Hattersley, Renström, F, Grallert, H, Wichmann, H. -E, Lamina, C. (Claudia), Sanna, S. (Serena), Morris, A.P., Caulfield, M. J, Karen L. Mohlke, Jameson, K., Sandhu, M.S., Forouhi, N.G. (Nita), Anne U. Jackson, Zillikens, MC, Meitinger, T. (Thomas), Leif Groop, Dominiczak, A. (Anna), Loos, R. J. F, Deloukas, P. (Panagiotis), Erdos, Michael R, Jacobs, L.C. (Leonie), Timpson, N.J., Tuomilehto Jaakko, Barroso, Ine S., Bumpstead, Suzannah J, Tuomilehto, Jaakko, Jackson, A. U, Palmer, Colin N. A.; id_orcid, Ebrahim Shah, Zhang Cuilin, Coin, Lachlan, Uda, M., Samani, NJ, Abecasis, Gonçalo R., Chines Peter, Witteman, JC, Rivadeneira Ramirez, F. (Fernando), Franks, Paul W,, Franks, Paul W., Schlessinger David, Laakso Markku, Amin, Najaf, Kijoung Song, Morris Andrew P., Caulfield, M. (Mark), Wareham, N. J, Sandhu, MS, Boehnke, M, Groop, L, Ruth J. F. Loos, Sanna, S, H.-Erich Wichmann, Isomaa, B., Jackson, Anne U., Wichmann, H.-E., Elliott, Paul, Joel N Hirschhorn, Renstrom, F., Illig Thomas, Chambers John C., Peltonen, L, Palmer, Colin N. A., Hu, F.B., Yuan, X. (Xin), Peden, J. (John), Peter Vollenweider, Cherkas, L. (Lynn), Ben A. Oostra, Groop Leif, Swift, A.J., Manuela Uda, Groves, Christopher J, Thorleifsson, G. (Gudmar), Isomaa, B. (Bo), Palmer, Colin NA, Heather M Stringham, Ebrahim, S., Wichmann, H.E., Heid, I.M., Kong, Augustine, Lawlor, D.A. (Debbie), Zhang, W, Mooser, Vincent, Uitterlinden, AG, Illig, T. (Thomas), David P Strachan, Zillikens, M.C. (Carola), Bandinelli, S., Speliotes, E.K., Chambers, J.C. (John), Manjinder S. Sandhu, Gieger, C, Nordström, Peter,, Scott, L. J, Chanock, Stephen J, Amanda J. Bennett, Zhang, C, McCarthy for the GIANT consortium, Mark I., Wichmann, H-Erich, Unnur Thorsteinsdottir, Watkins, H., Erdos, Michael R., Cornelia M van Duijn, Schlessinger, D., Timothy D Spector, Isomaa, B, Narisu, N., Silander, K. (Kaisa), Mark J. Caulfield, Chris Wallace, van Duijn, CM, Scheet, P. (Paul), Zhang, W.H., Havulinna, Aki S., Jarvelin, M.R., Ferrucci, L. (Luigi), Bumpstead, Suzannah J., Hirschhorn, J. N, Havulinna, A.S., Scott Grundy, Wallace, Chris, Fredrik Karpe, Kooner Jaspal S., Munroe, P. (Patricia), ?, ?, Salomaa, V, Zhao, Jing Hua, Steinthorsdottir, V, Zwart, J-A. (John-Anker), Witteman, Jacqueline C M, Consortia, HWPROCARDIS, Michael N. Weedon, Zillikens, M Carola, Lori L Bonnycastle, Jaspal S Kooner, Jarvelin Marjo-Riitta, Soranzo, N. (Nicole), Grallert Harald, Renstroem, F, Hirschhorn Joel N., Uda, Manuela, Palmer, C. N. A, Bandinelli, Stefania, Isomaa, Bo, Prokopenko, Inga, Zillikens, M.C., Francis S Collins, Narisu Narisu, Lathrop, G. M, Amy J Swift, Groves, Christopher J., Lawlor, Debbie A., Jacqueline C M Witteman, Loos, R.J.F. (Ruth), Wareham, N.J. (Nick), Frayling Timothy M., Chines, P., Scuteri, A., Deloukas Panos, Hunter, David J, Timpson, N. J, Abecasis, G.R., Nicholas J Timpson, Jousilahti Pekka, Morris, Andrew P, Morris, Andrew D, Herrera, B.M., Renström, Frida, Nicholas J Wareham, Tuomilehto, J. (Jaakko), Coin, L., Stringham, H.M., Nordstrom, A., Bennett, A.J. (Amanda), Augustine Kong, Vincent Mooser, Laakso, M., Narisu, N. (Narisu), Rolf Holle, Ferrucci, L, Kuusisto, J., van Duijn, C.M., Laitinen, J, Almgren Peter, Colin N. A. Palmer, Nordström, Anna, Karpe Fredrik, Uitterlinden, A.G. (André), Forouhi, Nita G, McArdle, Wendy L., Anders Hamsten, G Bragi Walters, Luigi Ferrucci, M. Carola Zillikens, Cherkas, L, Edward Lakatta, Hunter, D. J, Lim, N. (Noha), Paul Elliott, Nordstroem, P, Morris, A.D., H-Erich Wichmann, Willer, C.J., Deloukas, P., Yuan, X, Mooser, V. (Vincent), Lyon Helen N., Spector Timothy D., Suzannah J. Bumpstead, Grundy, S.M. (Scott), Uitterlinden, André G.; id_orcid, Doney, Alex S.F., Franks, Paul, Wareham, NJ, Peden, J. F, Frayling, TM, Chambers, John C., Nita G Forouhi, McCarthy, M.I., Holloway, John W., Waeber, Gerard, John F Peden, Morris, Andrew P., Jameson, Karen, Grallert, H. (Harald), The Wellcome Trust Case Control Consortium, Amy J. Swift, Walters, G. B, Collins, Francis S., Samani, N.J. (Nilesh), Boehnke Michael, Willer Cristen J., Wallace, C., Deloukas, Panos, Samani, N. J, Dominiczak Anna, Strachan, D. P, Zhang, C.L., Prokopenko Inga, Witteman Jacqueline C. M., Chanock, SJ, Wareham, Nicholas J., Laura J. Scott, Grundy, Scott, Laitinen, Jaana, Watkins for the PROCARDIS consortia, Hugh, Elizabeth K. Speliotes, Stephen J. Chanock, Wichmann H.-Erich, Boehnke, M. (Michael), Tikka-Kleemola, P. (Päivi), Abecasis, GR, Oostra, B.A. (Ben), Walters, GB, Oostra, BA, Speliotes, EK, Karpe, Fredrik, Timpson, Nicholas J., Smith, A.V. (Davey), Jing, H. Z, Zhao, J.H., Hofman, Albert, Tuomilehto, J, Isomaa Bo, Mark I McCarthy, André G. Uitterlinden, Scheet Paul, Bumpstead, SJ, Meitinger, Thomas, Crawford, G, Morken, MA, Holle, R, Hamsten, A, Strachan, D.P. (David), Weedon, M.N., Franks, Paul W, Christopher J. Groves, Crawford, Gabriel, van Duijn Cornelia M., Day, Ian N M, Sandhu, M. S, Strachan, DP, G. Mark Lathrop, Coin Lachlan, Lakatta, E. (Edward), Bonnycastle Lori L., Stefania Bandinelli, Spector, TD, Jacobs, Leonie C., Bo Isomaa, Witteman, J.C., Frank B Hu, Anne U Jackson, Mohlke, Karen L, Wichmann, H. -Erich, Payne, F., Elliott Paul, Paul Scheet, Uda Manuela, Hu, F.B. (Frank), Waterworth Dawn M., Ferrucci, L., Bonnycastle, L. L, Wichmann, H.E. (Erich), Stefansson Kari, Timothy M. Frayling, Mohlke, Karen L., Speliotes, E.K. (Elizabeth), Heid, Iris M., Tanaka, T., Lindgren, Cecilia M., Hattersley, Andrew T., Jackson, AU, Jousilahti, P., Peden, JF, Uda, M. (Manuela), Witteman, Jacqueline C. M., Herrera, Blanca M, Wallace, C. (Chris), Peltonen, L., Nordström, Peter, Strachan, David P, Groves, C. J, Hunter, David, Abecasis, G.R. (Gonçalo), Tanaka Toshiko, Speliotes, Elizabeth K, Hu, Frank B, Samani, Nilesh J., Smith, G. D, Sandhu, Manjinder S, Chines, P.S. (Peter), Prokopenko, I. (Inga), Watkins, H, Herrera, B. M, Wallace Chris, Harald Grallert, McCarthy For The Giant Consortium, MI, Jousilahti, P. (Pekka), Palmer, C.N.A., Ferrucci, Luigi, Soranzo, N, Andrew T Hattersley, Bergman, R. N, Paul W Franks, Oostra, B. A, Speliotes, Elizabeth K., Cooper, C., Stephen J Chanock, Nita G. Forouhi, Aulchenko Yurii S., Holloway, J. W, Heid, IM, Jarvelin, Marjo Riitta, Wallace, C, Havulinna, AS, Day, IN, Wichmann, H.-Erich, Meitinger Thomas, Hamsten, A., Sandhu Manjinder S., Bumpstead, S. (Suzannah), Gieger, C., Nordström, A. (Anna), Hattersley Andrew T., Doering Angela, Zhang, CL, Morken Mario A., Shah Ebrahim, Rivadeneira, Fernando, Elliott, P. (Paul), John W Holloway, Lathrop, GM, Gudmar Thorleifsson, John W. Holloway, Herrera Blanca M., Willer, CJ, Coin, L, Grallert, Harald, Cyrus Cooper, Richard N. Bergman, Noha Lim, Jarvelin, M-R, Weihua Zhang, Karen L Mohlke, Laitinen Jaana, Speliotes Elizabeth K., Fischer Guido, Zhang, C., Lawlor, DA, Havulinna, Aki S, Leonie C. Jacobs, Jarvelin, M. -R, Bumpstead, S. J, Chambers, JC, Waterworth, D.M., Thorsteinsdottir Unnur, Peden John F., Guiducci, C., Scheet, Paul, Mangino, Massimo, McCarthy for the GIANT consortium Mark I., Bergman, R.N. (Richard), Hadley, D, Lawlor, D. A, Lim, Noha, Thorsteinsdottir, Unnur, Christopher J Groves, Willer, Cristen J., Renström, Frida,, Lynn Cherkas, Hamsten, A. (Anders), Cherkas Lynn, Davey Smith, G, Palmer Colin N. A., Stefansson, K., Dominiczak, A, Chines, Peter, Lyon, Helen N., Forouhi, N.G., Karpe, F. (Fredrik), Payne, F, Nordström, Anna,, Munroe, Patricia, Randall, JC, Scheet, P, Kong, A, Doney, Alex S. F., Johanna Kuusisto, Bergman Richard N., McCarthy, Mark I., Massimo Mangino, Wellcome Trust Case Control Consor, Peden, J.F., Hunter, David J., Fischer, Guido, Thorleifsson, G, Timpson, NJ, Doney Alex S. F., Jousilahti, Pekka, Thorleifsson Gudmar, Frank B. Hu, Strachan, D.P., Holloway, John W, Peter Almgren, Scuteri, A, Peden, John F, Hadley David, Alex S. F. Doney, Yurii S Aulchenko, Ben A Oostra, Rivadeneira, F., Jameson, K, Kong, A. (Augustine), Chanock Stephen J., Angelo Scuteri, Mooser, V, Song, K., Hattersley, A.T. (Andrew) +999 morecore +1 more sourceThe Fto Gene Regulates the Proliferation and Differentiation of Pre-Adipocytes in Vitro [PDF]
Nutrients, 2016 The highly regulated differentiation and proliferation of pre-adipocytes play a key role in the initiation of obesity. Fat mass and obesity associated (FTO) is a novel gene strongly associated with the risk of obesity. A deficiency of FTO may cause growth retardation in addition to fat mass and adipocyte size reduction in vivo.Jiao, Yang, Zhang, Jingying, Lu, Lunjie, Xu, Jiaying, Qin, Liqiang +4 moreopenaire +2 more sourcesCausalCellInfer: Prioritizing Cell‐Type‐Specific Disease Associations From Genetically Predicted Transcriptomes in Biobank Cohorts
Advanced Science, EarlyView.Bulk and genotype‐imputed transcriptomes obscure the cellular drivers of complex disease. CausalCellInfer resolves them by integrating invariant marker selection, deep learning deconvolution, and regularized matrix completion. Applied to ∼500 000 UK Biobank participants across 29 traits, it uncovers hallmark cell‐type proportion shifts, including ...Liangying Yin, Yujia Shi, Ruoyu Zhang, Yong Xiang, Jinghong Qiu, Pak‐Chung Sham, Hon‐Cheong So +6 morewiley +1 more sourceFTO gene association with depression – Does FTO gen affect obesity in patients with depression
, 2022 Depression is a complex psychiatric disorder following many comorbidities such as diabetes, insulin resistance and obesity. Depression during childhood is associated with increased body mass index (BMI), while depression increases the odds of obesity, leading to major depressive disorders (MDD).Popović, Ana Marija, Mustač, Filip, Matovinović Osvatić, Martina, Marčinko, Darko +3 moreopenaire +2 more sourcesHepatic Lipid Stress Drives Metabolic Dysfunction‐Associated Steatohepatitis Progression through FTO O‐GlcNAcylation‐Induced m6A Demethylation of HRAS
Advanced Science, EarlyView.Lipid stress drives O‐GlcNAcylation of the m6A demethylase FTO at Ser195, enhancing its stability and demethylase activity. This modification removes m6A from HRAS mRNA, preventing its degradation and activating PI3K/AKT signaling to promote hepatic steatosis and inflammation.Jia‐Xin Yin, Yan‐Lai Zhang, Qun Liu, Rui Liu, Hai‐Yang Yuan, Sui‐Dan Chen, Ming‐Hua Zheng, Kai Wang, Ni Tang, Ai‐Long Huang +9 morewiley +1 more source
