Results 91 to 100 of about 7,322,114 (249)
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT Triple‐negative breast cancer (TNBC) is characterized as an aggressive malignancy with limited therapeutic options. The circular RNA circ_0006174 has been implicated in oncogenic processes across various cancers; however, its specific role in the pathogenesis of TNBC remains unclear.
Yong‐Zhe Tang +4 more
wiley +1 more source
FTO gene association with depression – Does FTO gen affect obesity in patients with depression
, 2022 Depression is a complex psychiatric disorder following many comorbidities such as diabetes, insulin resistance and obesity. Depression during childhood is associated with increased body mass index (BMI), while depression increases the odds of obesity, leading to major depressive disorders (MDD).
Popović, Ana Marija +3 more
openaire +2 more sources
BMC Medical Genetics, 2020 Background PCOS is a common disorder of women due to genetic, endocrine and environmental effects that manifests from puberty. The rs9939609 variant of fat mass and obesity associated (FTO) gene is linked to metabolic derangement in PCOS.
Umayal Branavan +4 more
doaj +1 more source
HSP90 inhibitors stimulate DNAJB4 protein expression through a mechanism involving N6-methyladenosine. [PDF]
, 2019 Small-molecule inhibitors for the 90-kDa heat shock protein (HSP90) have been extensively exploited in preclinical studies for the therapeutic interventions of human diseases accompanied with proteotoxic stress.
Chen, Xuemei +5 more
core +1 more source
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT Ibrutinib resistance remains a major obstacle in the treatment of diffuse large B‐cell lymphoma (DLBCL). Fat mass and obesity‐associated protein (FTO) has been implicated in drug resistance through its regulation of N6‐methyladenosine (m6A) modifications; however, whether FTO mediates ibrutinib resistance in DLBCL remains unclear.
Ting‐Ting Lu +5 more
wiley +1 more source
Indications for Potential Parent-of-Origin Effects within the FTO Gene
PLOS ONE, 2015 Genome-Wide Association Studies (GWAS) were successfully applied to discover associations with obesity. However, the GWAS design is usually based on unrelated individuals and inheritance information on the parental origin of the alleles is missing.
Liu, Xuanshi +8 more
openaire +5 more sources
Association of FTO and PPARG polymorphisms with obesity in Portuguese women [PDF]
, 2013 Purpose: We evaluated the association between risk of obesity in the Portuguese population and two obesity-related single-nucleotide gene polymorphisms: fat-mass and obesity-associated (FTO) rs9939609 and peroxisome proliferator-activated receptor gamma (
Baptista, Pedro Viana +6 more
core +1 more source
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT Microglia play an important role in ischemic stroke (IS). However, the molecular regulatory mechanisms underlying microglial ferroptosis in IS remain incompletely understood. In this study, blood samples were collected from 20 IS patients and 15 healthy volunteers.
Ai‐Xia Song +7 more
wiley +1 more source
Regulation ofFto/Ftmgene expression in mice and humans [PDF]
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 2008 Two recent, large whole-genome association studies (GWAS) in European populations have associated a ∼47-kb region that contains part of the FTO gene with high body mass index (BMI). The functions of FTO and adjacent FTM in human biology are not clear.
Stratigopoulos, G +8 more
openaire +2 more sources
Association of single nucleotide polymorphisms in the fatty acid synthase, LOC514211, and fat mass and obesity-associated genes with milk traits in Indonesian-Holstein dairy cattle [PDF]
Veterinary World, 2019 Aim: The study aimed to identify fatty acid synthase (FASN), LOC514211, and fat mass and obesity-associated (FTO) gene polymorphisms and to investigate their associations with milk traits in an Indonesian-Holstein dairy cow population.
Amalia Puji Rahayu +3 more
doaj +1 more source