Results 81 to 90 of about 7,322,114 (249)

Role of FTO in adipocyte development and function: recent insights [PDF]

, 2015
In 2007, FTO was identified as the first genome-wide association study (GWAS) gene associated with obesity in humans. Since then, various animal models have served to establish the mechanistic basis behind this association.
Merkestein, Myrte, Sellayah, Dyan
core   +2 more sources

A nutrigenetic approach to investigate the relationship between metabolic traits and vitamin D status in an Asian Indian population [PDF]

, 2020
Studies in Asian Indians have examined the association of metabolic traits with vitamin D status. However, findings have been quite inconsistent. Hence, we aimed to explore the relationship between metabolic traits and 25-hydroxyvitamin D [25(OH)D ...
Alathari, Buthaina E., Anjana, Ranjit Mohan, Bodhini, Dhanasekaran, Jayashri, Ramamoorthy, Lakshmipriya, Nagarajan, Lovegrove, Julie A., Mohan, Viswanathan, Pradeepa, Rajendra, Radha, Venkatesan, Rani, Coimbatore Subramanian Shanthi, Sudha, Vasudevan, Vimaleswaran, Karani S.   +11 more
core   +1 more source

Bridging maternal effects and epitranscriptomics: A novel perspective in developmental biology

Developmental Dynamics, EarlyView.
Abstract Maternal effects, encompassing both genetic (maternally expressed gene products) and non‐genetic (maternal state) influences, are powerful determinants of offspring phenotype, yet their RNA‐level mechanisms remain incompletely resolved. In parallel, epitranscriptomics, an emerging field centered on chemical modifications to RNA, has revealed ...
Ehsan Pashay Ahi
wiley   +1 more source

Common Variant ofFTOGene, rs9939609, and Obesity in Pakistani Females [PDF]

BioMed Research International, 2013
Numerous studies confirmed the association ofFTO(fat mass and obesity associated gene) common variant, rs9939609, with obesity in European populations. However, studies in Asian populations revealed conflicting results. We examined the association of rs9939609 variant ofFTOgene with obesity and obesity-related anthropometric and metabolic parameters in
Shahid, Adeela, Rana, Sobia, Saeed, Shahid, Imran, Muhammad, Afzal, Nasir, Mahmood, Saqib   +5 more
openaire   +2 more sources

Influence of SNP mutations in FTO and LEP genes on body mass in bovine populations

Acta Agriculturae Slovenica, 2016
Body mass gain in a certain time period is one of the most important parameters in beef production. Some candidate genes, which have major impact on growth traits, are known from the literature, notably among them the FTO (fat mass and obesity-associated)
Iva ČERNOŠA, Žan PIRC, Andrej RENČELJ   +2 more
doaj   +1 more source

FTO – A Common Genetic Basis for Obesity and Cancer

Frontiers in Genetics, 2020
In recent years, the prevalence of obesity and cancer have been rising. Since this poses a serious threat to human health, the relationship between the two has attracted much attention.
Ning Lan, Ning Lan, Ning Lan, Ying Lu, Ying Lu, Ying Lu, Yigan Zhang, Yigan Zhang, Yigan Zhang, Shuangshuang Pu, Huaze Xi, Xin Nie, Jing Liu, Wenzhen Yuan, Wenzhen Yuan, Wenzhen Yuan   +15 more
doaj   +1 more source

Epigenetic Regulation in the Pathogenesis of Renal Inflammation: Insights and Therapeutic Potentials

iNew Medicine, EarlyView.
ABSTRACT Renal inflammation is a common pathological process in various kidney diseases, often initiated by factors such as toxins, ischemia, or autoimmune reactions. This inflammatory response can result in structural damage and a rapid decline in renal function.
Yu‐Hang Dong, Xiao‐Yu Shen, Han‐Cheng Jin, Xiang‐Yu Li, Hao He, Xiao‐Ming Meng   +5 more
wiley   +1 more source

N6‐Methyladenosine (m6A) in Liver Disease: Pathogenic Mechanisms and Therapeutic Potential

iNew Medicine, EarlyView.
ABSTRACT Accumulating evidence highlights the critical role of epigenetic modifications, particularly N6‐methyladenosine (m6A), in liver disease. As the most abundant RNA modification in eukaryotic cells, m6A is dynamically regulated by multicomponent m6A methyltransferases (e.g., METTL3 and METTL14), demethylases (FTO and ALKBH5), and m6A‐binding ...
Yingfen Chen, Ru Ya, Ziling Zhang, Siyue Dong, Seol Hee Park, Wonhyo Seo, Yong He   +6 more
wiley   +1 more source

Hypothalamic-Specific Manipulation of Fto, the Ortholog of the Human Obesity Gene FTO, Affects Food Intake in Rats

PLoS ONE, 2010
Sequence variants in the first intron of FTO are strongly associated with human obesity and human carriers of the risk alleles show evidence for increased appetite and food intake. Mice globally lacking Fto display a complex phenotype characterised by both increased energy expenditure and increased food intake.
Tung, Yi-Chun Loraine, Ayuso, Eduard, Shan, Xiaoye, Bosch i Tubert, Fàtima, O'Rahilly, Stephen, Coll, Anthony P., Yeo, GS   +6 more
openaire   +6 more sources

Association of FTO gene variants with body composition in UK twins [PDF]

Annals of Human Genetics, 2012
SummaryThe association of FTO gene variants with body mass index (BMI) and other obesity characteristics is well established. However, uncertainties remain whether the association is present only in young populations and whether it is attributable to body fat mass specifically.
Livshits, Gregory, Malkin, Ida, Moayyeri, Alireza, Spector, Timothy D., Hammond, Christopher J.   +4 more
openaire   +3 more sources