Results 101 to 110 of about 2,549,001 (246)

Unraveling the directional link between adiposity and inflammation: a bidirectional mendelian randomization approach [PDF]

, 2010
<b>Context</b>: Associations between adiposity and circulating inflammation markers are assumed to be causal, although the direction of the relationship has not been proven. <b>Objective</b>: The aim of the study was to explore
Jukema, J.W., Schaefer, E., Welsh, P., Westendorp, R.G.J., Jahn, S., Packard, C.J., Craen, A.J.M. de, de Craen, A.J.M., Sattar, N., Smith, G.D., Hingorani, A.D., Ford, I., Polisecki, E., Smith, G.Y., Robertson, M., Buckley, B.M., Macfarlane, P.W., Stott, D.J., Shepherd, J., Sattar, N.A.   +19 more
core   +1 more source

FTO Inhibits Insulin Secretion and Promotes NF-κB Activation through Positively Regulating ROS Production in Pancreatic β cells.

PLoS ONE, 2015
FTO (Fat mass and obesity-associated) is associated with increased risk of obesity and type 2 diabetes incurrence. Pancreas islet β cells dysfunction and insulin resistance are major causes of type 2 diabetes.
Hong-Qi Fan, Wei He, Kuan-Feng Xu, Zhi-Xiao Wang, Xin-Yu Xu, Heng Chen   +5 more
doaj   +1 more source

Assessing effect of interaction between the FTO A/T polymorphism (rs9939609) and physical activity on obesity-related traits

Journal of Sport and Health Science, 2018
Background: The first described obesity-susceptibility gene was the fat mass and obesity-associated (FTO) gene. However, knowledge about FTO's potential modifying effect on changes in body weight achieved through a training program is still limited.
Agata Leońska-Duniec, Zbigniew Jastrzębski, Aleksandra Zarębska, Agnieszka Maciejewska, Krzysztof Ficek, Paweł Cięszczyk   +5 more
doaj   +1 more source

T/A Polymorphism of the FTO Gene and Adiposity in Young Mongolian Men

Central Asian Journal of Medical Sciences, 2019
Objectives: The purpose of the paper was to determine the association between T/A polymorphism of the FTO gene and fat accumulation and localization in young urban ethnic Mongolian males. Methods: The anthropogenetic study was conducted 247 ethnic Mongolian males in Ulaanbaatar, Mongolia from 18 to 24 years of age, whose parents were both of Mongolian ...
Elvira Bondareva, Lkhagvasuren Gundegmaa, Otgon Galsanjav   +2 more
openaire   +2 more sources

Targeted Perturbation of Mitochondrial Energy Metabolism via Thermoelectric Nanoflowers for Enhanced Cuproptosis Echoed With Immunotherapy

Advanced Science, EarlyView.
We fabricated a thermoelectric nanomedicine to disrupt the ATP energy supply for the copper transporter ATP7B, thereby enhancing cuproptosis and achieving synergistic immunotherapy for anti‐tumor purposes. The fabricated TBCT NFs can efficiently disrupt the electron transport chain function via superoxide‐induced NADH oxidation, leading to ATP ...
Haoyang Du, Chao Xu, Hao Wang, Bo Peng, Peng Liu, Wei Gao, Tao Ye, Xinyuan Yu, Ying Shi, Jiaxin Liu, Tiancong Zhao, Bin Sun, Piaoping Yang, Manjie Zhang   +13 more
wiley   +1 more source

Smart Exploration of Perovskite Photovoltaics: From AI Driven Discovery to Autonomous Laboratories

Advanced Energy Materials, EarlyView.
In this review, we summarize the fundamentals of AI in automated materials science, and review AI applications in perovskite solar cells. Then, we sum up recent progress in AI‐guided manufacturing optimization, and highlight AI‐driven high‐throughput and autonomous laboratories.
Wenning Chen, Zheyu Zhang, Kelvian T. Mularso, Bonghyun Jo, Hyun Suk Jung   +4 more
wiley   +1 more source

Expression of FTO gene in different tissues of mouse.

, 2015
(A) FTO expression in various mouse tissues measured by Real-time PCR. The data were calculated as relative fold changes between each sample and the one with the lowest expression level of FTO.
Heng Chen (487476), Xin-Yu Xu (745970), Hong-Qi Fan (430278), Zhi-Xiao Wang (430279), Wei He (131453), Kuan-Feng Xu (745969)   +5 more
core   +1 more source

An Obesity-Predisposing Variant of the FTO Gene Regulates D2R-Dependent Reward Learning [PDF]

, 2015
Variations in the fat mass and obesity-associated (FTO) gene are linked to obesity. However, the underlying neurobiological mechanisms by which these genetic variants influence obesity, behavior, and brain are unknown.
Gruendler, Theo O J, Tittgemeyer, Marc, Bruning, Jens C, Ullsperger, Markus, Schilbach, Leonhard, Kuhn, Anne B, Mauer, Jan, Hess, Martin E, Stephan, Klaas Enno, Sevgi, Meltem, Rigoux, Lionel   +10 more
core   +2 more sources

Metal nanostructure‐coupled label‐free localized surface plasmon resonance biosensors for rapid and sensitive disease diagnosis

BMEMat, EarlyView.
LSPR biosensing enables rapid, sensitive, and low‐sample‐volume detection of biomarkers, with broad applications in diagnosing cancer, infectious, and chronic diseases. Advances in nanostructure design, micro/nanofabrication, and microfluidic integration have expanded the potential of LSPR sensors in biomedical diagnostics.
Zhaoxin Geng, Yunfei Sha, Jiongyan Yang, Hongru Yang, Xiao Liang   +4 more
wiley   +1 more source

Tackling cancer stemness with nanotechnology in the era of precision medicine

BMEMat, EarlyView.
Precise customization of nanoparticles (NPs) enables active targeting of cancer stem cells (CSCs), thereby improving drug delivery and therapeutic efficacy. NP‐based probing enhances CSC detection through imaging and liquid biopsy, whereas diverse therapeutic payloads improve therapeutic outcomes.
Shaolei Guo, Shun Yao, Lihui Meng, Chunyuan Chen, Yuechu Lucinda Lu, Rong Lu, Kashif Rafiq Zahid, Umar Raza, Qingzhi Wu, Wenli Chen   +9 more
wiley   +1 more source