Results 121 to 130 of about 15,826 (205)
Interaction of common variants of FTO gene and Dietary Inflammatory Index on obesity measures: Tehran Lipid and Glucose Study. [PDF]
Haji-Hosseini-Gazestani N +6 more
europepmc +1 more source
This study identifies tRNA methyltransferase 61 A (TRMT61A)‐mediated N1‐methyladenosine (m1A) modification as a driver of radioresistance in hepatocellular carcinoma (HCC) by suppressing cuproptosis. TRMT61A methylates FDX1 mRNA, enabling YTHDF3 recognition and eRF1 recruitment to inhibit FDX1 translation.
Yunyun Xiao +10 more
wiley +1 more source
ABSTRACT N6‐methyladenosine (m6A) is the most abundant internal chemical modification of eukaryotic RNA and a central mechanism of epitranscriptomic gene regulation. Although m6A was first characterized in messenger RNA (mRNA), it is also deposited on ribosomal RNA (rRNA), circular RNA, and other RNA species, where it regulates RNA stability, decay ...
Shoichiro Kokabu, Quan Yuan
wiley +1 more source
Effects of Helicobacter pylori on the expression of the FTO gene and its biological role in gastric cancer. [PDF]
Gui S +9 more
europepmc +1 more source
Overview of gold nanomaterial‐based biosensing strategies for early breast cancer diagnosis. The figure illustrates the detection of multiple biomarker classes, including proteins, nucleic acids, circulating tumor cells (CTCs), and exosomes from biological samples such as blood, serum, and cell lysates using electrochemical, SPR, SERS, fluorescence ...
Akanksha Pawar +6 more
wiley +1 more source
SCAPS‐1D modeling shows that bandgap‐engineered Se0.75Te0.25 (Eg ≈ 1.35 eV) can support high‐efficiency thin‐film photovoltaics through absorber, interface, and rear‐contact optimization. A MoOx‐based device reaches 21.94% PCE, while an HTL‐free configuration with a 5.5 eV rear‐contact work function achieves 21.59%.
Saif M. H. Qaid +6 more
wiley +1 more source
METTL3‐mediated m6A modification stabilizes KDR/Kdr mRNA through YTHDC2, amplifying the VEGFA‐KDR feedback loop and disturbing Th17/Treg balance. This pathway promotes persistent inflammation and tissue damage in patients with AIT, and inhibiting the METTL3‐KDR axis effectively disrupts this circuit, alleviating thyroid tissue injury and disease ...
Qingyi Hu +7 more
wiley +1 more source
Cool executive functions and their association with body mass & fatness and the FTO gene in school-aged children. [PDF]
Szcześniewska P +8 more
europepmc +1 more source
IGF2BP1‐mediated m6A stabilization sustains SMC1A expression, enabling cohesin‐associated chromatin regulation of Nestin in hepatocellular carcinoma. This work reveals an epitranscriptomic‐chromatin‐cytoskeletal regulatory axis linked to malignant phenotypes and identifies SMC1A as a biologically relevant vulnerability in HCC.
Zhenxiang Peng +7 more
wiley +1 more source
Lack of association of the alpha-ketoglutarate-dependent dioxygenase (FTO) gene polymorphisms with pulmonary tuberculosis risk: a systematic review and meta-analysis. [PDF]
Lamichhane P +7 more
europepmc +1 more source

