Results 131 to 140 of about 15,826 (205)

Metabolomics of Eryngium heterophyllum by UHPLC‐QToF‐MS and In Silico Insights Into Potential Metabolic Syndrome Targets

open access: yesChemistry &Biodiversity, Volume 23, Issue 8, August 2026.
Eryngium heterophyllum has 85 metabolites according to nontargeted UHPLC‐QTOF‐MS profiling, with flavonoids and phenylpropionic acids emerging as significantly related bioactive families. In silico compound–disease–target networks connect 31 metabolites to inflammation, diabetes, obesity, and cardiovascular disease associated with metabolic syndrome ...
Citlaly Gutiérrez‐Rodelo   +5 more
wiley   +1 more source

Epigenetic Regulation of Bone Homeostasis in Osteoporosis: Mechanisms, Evidence Gaps, and Translational Prospects

open access: yesCell Biochemistry and Function, Volume 44, Issue 8, August 2026.
ABSTRACT Osteoporosis arises from an imbalance among osteoblast‐mediated bone formation, osteoclast‐mediated bone resorption, and osteocyte‐directed mechanosensory control, but the molecular events that connect aging, hormonal change, inflammation, and mechanical unloading to bone loss remain incompletely resolved.
Minjuan Du, Leisheng Wang
wiley   +1 more source

N6‐Methyladenosine Demethylase FTO Mitigates Cerebral Ischemia–Reperfusion Injury by Suppressing AQP4 Expression

open access: yesCNS Neuroscience &Therapeutics, Volume 32, Issue 8, August 2026.
Mechanism of FTO regulating Hspa1a m6A modification for protection against CIRI. A CIRI leads to a decrease in FTO expression in astrocytes followed by an increase in Hspa1a m6A modification, which promotes HSPA1A degradation. Simultaneously, the NF‐κB pathway becomes activated, and AQP4 expression is upregulated.
Wei Chen   +9 more
wiley   +1 more source

The effects of FTO gene rs9939609 polymorphism on the association between breast cancer and dietary intake. [PDF]

open access: yesJ Cell Mol Med, 2022
Doaei S   +16 more
europepmc   +1 more source

Bard1‐Mediated Regulation of Hnrnpa2b1 Ubiquitination and Protein Stability Contributes to Neuronal Ferroptosis and Cognitive Dysfunction Following Ischemic Stroke

open access: yesCNS Neuroscience &Therapeutics, Volume 32, Issue 8, August 2026.
Bard1‐mediated ubiquitination of Hnrnpa2b1 in mice with PSCI destabilizes Sptbn2, which prevents the membrane translocation of Slc7a11 and reduces cystine uptake. This disruption of antioxidant defense triggers ferroptosis in hippocampal neurons, highlighting a novel molecular pathway linking post‐stroke cognitive impairment to ferroptosis of ...
Tuming Li   +6 more
wiley   +1 more source

Unraveling the Complex Interactions between the Fat Mass and Obesity-Associated (FTO) Gene, Lifestyle, and Cancer. [PDF]

open access: yesAdv Nutr, 2022
Abdollahi S   +7 more
europepmc   +1 more source

The evolving landscape of the Warburg effect in gastric cancer: From molecular mechanisms to targeted therapy

open access: yesClinical and Translational Medicine, Volume 16, Issue 8, August 2026.
Hypoxia, oncogenic signaling, transcriptional and epigenetic remodeling, and H. pylori–microbiota interactions drive the Warburg effect in gastric cancer. Enhanced glycolysis and lactate export support biosynthesis, remodel the tumor microenvironment, promote stromal activation and immune suppression, and reveal actionable biomarkers and therapeutic ...
Guanmo Liu   +7 more
wiley   +1 more source

Do Linking‐Expression Substitutions Mitigate Deterministic Interpretations of Genetic Information?

open access: yesJournal of Applied Philosophy, Volume 43, Issue 4, Page 973-996, August 2026.
ABSTRACT It is a common concern that broader audiences interpret scientific information about the genetic correlates and causes of complex human traits in an overly deterministic manner. A frequently proposed way to address this issue is to carefully select the linking expressions used to describe gene–trait relationships when communicating genetic ...
Riin Kõiv
wiley   +1 more source

The effect of FTO gene rs9939609 polymorphism on the association between colorectal cancer and different types of dietary fat intake: a case-control study. [PDF]

open access: yesJ Physiol Anthropol, 2023
Hajipour A   +12 more
europepmc   +1 more source

Morroniside Attenuates Doxorubicin‐Induced Cardiotoxicity by Activating the PI3K/AKT/Nrf2/HO‐1 Pathway to Inhibit Ferroptosis and Oxidative Stress

open access: yesJournal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.
Mor activates the PI3K/AKT pathway to promote Nrf2 nuclear translocation and HO‐1 expression, enhancing antioxidants, curbing Fe2+‐induced ROS/lipid peroxidation, suppressing ferroptosis, and alleviating Dox‐induced cardiotoxicity. ABSTRACT Cardiotoxicity induced by doxorubicin (Dox) significantly contributes to increased mortality among cancer ...
Zhi‐Hui Lin   +5 more
wiley   +1 more source

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