Results 151 to 160 of about 2,549,001 (246)

Impact of the FTO Gene Variation on Appetite and Fat Oxidation in Young Adults. [PDF]

Nutrients, 2023
Ponce-Gonzalez JG, Martínez-Ávila Á, Velázquez-Díaz D, Perez-Bey A, Gómez-Gallego F, Marín-Galindo A, Corral-Pérez J, Casals C.   +7 more
europepmc   +1 more source

From Association to Mechanism: Regulatory Annotation and Pathway Mapping of Genes Surrounding Breast Cancer Risk Variants

Computational and Systems Oncology, Volume 6, Issue 1, December 2026.
ABSTRACT Inherited factors account for a large share of breast cancer susceptibility, yet the biological consequences of most risk variants are still poorly understood. To address this gap, we studied 175 breast cancer risk variants confirmed by genome‐wide association studies and gathered the genes that lie near them.
Sultana Jannat, Trina Mitra, Nafisa Nawar Fariha, Tasmia Tabassum, Kulsuma Bahar Bethi, Synchita Majumder Kaya, Md. Arif Hossen, Md. Saad Hossain, Jobaier Ibne Deen, Mohammed Emon, Laila Khaleda, Md. Hridoy Ahmed   +11 more
wiley   +1 more source

The effects of FTO gene rs9939609 polymorphism on the association between colorectal cancer and dietary intake. [PDF]

Front Nutr, 2023
Gholamalizadeh M, Jonoush M, Mobarakeh KA, Amjadi A, Alami F, Valisoltani N, Askarpour SA, Azizi-Tabesh G, Mohammadian MK, Akbari ME, Rajabibazl M, Alemrajabi M, Poodineh J, Sadeghi H, Hosseinzadeh P, Dahka SM, Badeli M, Jarrahi SAM, Doaei S, Doaei S.   +19 more
europepmc   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, Volume 20, Issue 10, Page 2510-2532, October 2026.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Genetic Markers as Instrumental Variables [PDF]

The use of genetic markers as instrumental variables (IV) is receiving increasing attention from epidemiologists, economists, statisticians and social scientists.
Frank Windmeijer, Carol Propper, Stephanie von Hinke Kessler Scholder, George Davey Smith, Debbie A. Lawlor   +4 more
core  

Effects of Helicobacter pylori on the expression of the FTO gene and its biological role in gastric cancer. [PDF]

Oncol Lett, 2023
Gui S, Wang Q, Bao L, He X, Wang Z, Liu L, Wu L, Zhao Y, Zhou J, Xie Y.   +9 more
europepmc   +1 more source

WDR72 Promotes Neuroblastoma Stemness and Progression by Sequestering TRIM31‐Mediated Degradation of CBX8

Advanced Science, Volume 13, Issue 56, 9 October 2026.
This study unveiled that METTL14 mediates m6A modification of WDR72 mRNA to stabilize and enhance WDR72 expression, which disrupts TRIM31‐mediated ubiquitination of CBX8 protein and retards its degradation, finally the elevated CBX8 contributes to tumor stemness.
Huijuan Zeng, Zijie Ye, Manna Zheng, Jing Pan, Tianbao Tan, Jiliang Yang, Jiahao Li, Zhang Zhao, Tianzhu Long, Liyu Zhang, Gautam Sethi, Tianyou Yang, Chao Hu, Yan Zou   +13 more
wiley   +1 more source

Interaction of common variants of FTO gene and Dietary Inflammatory Index on obesity measures: Tehran Lipid and Glucose Study. [PDF]

BMJ Nutr Prev Health, 2023
Haji-Hosseini-Gazestani N, Hosseini-Esfahani F, Ataie-Jafari A, Goodarzi G, Daneshpour MS, Mirmiran P, Azizi F.   +6 more
europepmc   +1 more source

Lactate metabolism and protein lactylation in programmed cell death: From novel mechanism to therapeutic strategies in human diseases

Clinical and Translational Medicine, Volume 16, Issue 10, October 2026.
This review highlights protein lactylation as a metabolic‐epigenetic regulator linking lactate reprogramming to programmed cell death. By modulating histone and non‐histone targets, lactylation reshapes cell fate decisions and represents a promising biomarker and therapeutic target in human diseases.
Yue Chen, Xiwen Wang, Xiuping Wang, Na Lin, Wenjie Wang, Ruiqi Fu, Yutong Wu, Yi Liu, Hengwei Liu   +8 more
wiley   +1 more source

Association of FTO and PPARG polymorphisms with obesity in Portuguese women

, 2013
Fábio Ferreira Carlos,1,2 José Silva-Nunes,3,4 Orfeu Flores,1 Miguel Brito,3 Gonçalo Doria,1 Luísa Veiga,3 Pedro Viana Baptista1 1Centro de Investigação em Genética Molecular Humana, Universidade Nova de ...
Brito M, Baptista PV, Flores O, Silva-Nunes J, Ferreira Carlos F, Veiga L, Doria G   +6 more
core