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The Impact of Haplotypes of the FTO Gene, Lifestyle, and Dietary Patterns on BMI and Metabolic Syndrome in Polish Young Adult Men. [PDF]

Nutrients
Górczyńska-Kosiorz S, Lejawa M, Goławski M, Tomaszewska A, Fronczek M, Maksym B, Banach M, Osadnik T.   +7 more
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The FTO Obesity Gene. Genotyping and Gene Expression Analysis in Morbidly Obese Patients

Obesity Surgery, 2008
Obesity has emerged as one of the most serious public health concerns in the twenty-first century. the fat mass and obesity associated gene (FTO) has been found to contribute to the risk of obesity in humans. Our aims in this study were to investigate the association of rs9939609 single nucleotide polymorphism (SNP) of the FTO gene with different ...
Arturo Corbatón-Anchuelo, Serrano-Rios Manuel, María T Martı́Nez-Larrad   +2 more
exaly   +3 more sources

Inactivation of the Fto gene protects from obesity

Nature, 2009
Several independent, genome-wide association studies have identified a strong correlation between body mass index and polymorphisms in the human FTO gene. Common variants in the first intron define a risk allele predisposing to obesity, with homozygotes for the risk allele weighing approximately 3 kilograms more than homozygotes for the low risk allele.
Julia, Fischer, Linda, Koch, Christian, Emmerling, Jeanette, Vierkotten, Thomas, Peters, Jens C, Brüning, Ulrich, Rüther   +6 more
openaire   +2 more sources

Allelic Polymorphism Detected in the Bovine FTO Gene

Molecular Biotechnology, 2011
Studies in humans have independently identified single nucleotide polymorphisms (SNPs) in the fat mass and obesity associated (FTO) gene associated with obesity in multiple populations. It was shown that FTO participated in the regulation of energy homeostasis and associated with increased lipolytic activity in adipocytes.
Bao, Zhang, Ya, Zhang, Liangzhi, Zhang, Jing, Wang, Zhuanjian, Li, Hong, Chen   +5 more
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Influences of FTO gene on onset age of adult overweight

Human Genetics, 2012
FTO affects changes in BMI during both childhood and adulthood. However, its effect on onset age of overweight in adulthood is not known. To address this question, we conducted a study to examine effects of FTO tag SNPs on censored age of overweight in the longitudinal Bogalusa Heart Study (BHS) cohort, which began in 1973-1974.
Hao, Mei, Wei, Chen, Katherine, Mills, Jiang, He, Sathanur R, Srinivasan, Nicholas, Schork, Sarah, Murray, Gerald S, Berenson   +7 more
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Association of obesity with rs1421085 and rs9939609 polymorphisms of FTO gene

Molecular Biology Reports, 2014
The aim of this study is to investigate the genetic influence of polymorphisms in fat mass and obesity associated (FTO) gene on a sample of obese subjects and controls. Obesity is an epidemic all over the world. Several polymorphisms in the first intron of FTO gene have been associated with common forms of human obesity.
Solak, Mustafa, Erdogan, Mujgan Ozdemir, Yildiz, Saliha Handan, Ucok, Kagan, Yuksel, Seref, Terzi, Evrim Suna Arikan, Bestepe, Ahmet   +6 more
openaire   +3 more sources

Variants in the FTO gene are associated with common obesity in the Belgian population

Molecular Genetics and Metabolism, 2008
Three independent studies, of which two genome-wide scans, have reported an association between SNPs in the FTO (Fat mass and obesity associated) gene and obesity, in different European cohorts. We selected the SNPs with the strongest evidence for association from the first two studies and genotyped 1099 obese patients and 268 healthy control ...
Peeters, Armand, Beckers, Sigri, Verrijken, An, Roevens, Peter, Peeters, Pieter, Van Gaal, Luc, Van Hul, Wim   +6 more
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Cloning and characterization of chicken fat mass and obesity associated (Fto) gene: fasting affects Fto expression

Domestic Animal Endocrinology, 2012
Fat mass and obesity associated gene (Fto), also known as Fatso, is a member of the Fe-II and 2-oxoglutarate-dependent dioxygenase superfamily. Recent studies in humans and rodents suggest that Fto is involved in food intake regulation and lipid metabolism, whereas single nucleotide mutations in the Fto gene are associated with obesity and type 2 ...
A, Tiwari, S M, Krzysik-Walker, R, Ramachandran   +2 more
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