Targeted metabolomics suggests a probable role of the FTO gene in the kynurenine pathway in prediabetes. [PDF]
PeerJ, 2022 Chailurkit LO +4 more
europepmc +1 more source
Refining the Genetic Contribution to Type 2 Diabetes Subtypes
Diabetes, Obesity and Metabolism, Volume 28, Issue 10, Page 9450-9460, October 2026.ABSTRACT Background Type 2 diabetes (T2D) is a complex and highly heterogeneous disease driven in part by genetic predisposition and can be stratified into clinical subgroups to aid disease management. We recently grouped T2D subjects in the Qatar Biobank (QBB) cohort into Severe Insulin‐Deficient Diabetes (SIDD), Severe Insulin‐Resistant Diabetes ...
Nayra M. Al‐Thani +5 more
wiley +1 more source
Response of FTO gene polymorphisms to continuous caloric restriction diets on lipid and glycemic biomarkers in overweight and obese adults: a systematic review and meta-analysis. [PDF]
Nutr Metab (Lond)Duc TQ +3 more
europepmc +1 more source
Polyphenism Through RNA Chemical Modifications
Molecular Ecology, Volume 35, Issue 19, October 2026.ABSTRACT Polyphenism, the capacity of a single genotype to produce discrete phenotypes in response to environmental cues, has long served as a model for understanding developmental plasticity. While classical studies have highlighted hormonal signalling and transcription‐factor‐driven gene regulatory networks that mediate these environmentally induced ...
Ralf Schneider, Ehsan Pashay Ahi
wiley +1 more source
Impact of fat mass and obesity-associated (FTO) gene variants on adult obesity and overweight: a comprehensive meta-analysis. [PDF]
BMC Endocr DisordEghbali M +5 more
europepmc +1 more source
Annals of the New York Academy of Sciences, Volume 1564, Issue 1, October 2026.Epitranscriptomic marks are highly variable across life stages and tissues, complicating comparisons between species. Using m6A consensus motifs, we developed a genomic indicator reflecting transcript methylability, the DRACH o/e score, that we used to investigate epitranscriptomic features and associated functions across nine bilaterian species.
Natacha Clairet +4 more
wiley +1 more source
Association of fetal FTO gene variants with maternal postload glucose levels in pregnancy. [PDF]
Int J Obes (Lond)Firneisz G +8 more
europepmc +1 more source
Type 2 diabetes linked FTO gene variant rs8050136 is significantly associated with gravidity in gestational diabetes in a sample of Bangladeshi women: Meta-analysis and case-control study. [PDF]
PLoS One, 2023 Amin USM +6 more
europepmc +1 more source
Obesity Reviews, Volume 27, Issue 10, October 2026.ABSTRACT Excess adiposity is not a recently developed problem but has existed since at least the upper Paleolithic, allowing evolutionary selection pressures to adapt the physiology of the pregnant woman and the feto‐placental unit for maternal and fetal protection.
Gernot Desoye +6 more
wiley +1 more source