Results 161 to 170 of about 2,549,001 (246)
MedComm, Volume 7, Issue 10, October 2026.• EV content maintains cellular homeostasis and is involved in several disease onset and progression. • miRNA export in EVs depends on: RNA‐binding proteins recognizing motif sequences and on epitranscriptomic modifications. • The disclosure of delivery mechanisms is crucial for developing personalized EV‐based therapeutic tools. ABSTRACT Extracellular
Sabrina Garbo +4 more
wiley +1 more source
MedComm, Volume 7, Issue 10, October 2026.BTK inhibitors suppress malignant B‐cell signaling while simultaneously reshaping immune regulation through effects on T cells and the tumor microenvironment. These mechanisms support combination immunotherapy strategies and also underlie the expanding application of BTK inhibitors in solid tumors, autoimmune and inflammatory diseases.
Miao Sun, Dengju Li, Jia Wei
wiley +1 more source
MedComm, Volume 7, Issue 10, October 2026.In acute brain injury (TBI/ICH), sympathetic hyperactivity is driven by hypothalamic FTO upregulation. FTO demethylates Trhr, blocking m6A‐YTHDF2‐dependent degradation, which stabilizes Trhr mRNA and increases neuronal sensitivity to TRH. Restoring FTO or Trhr alleviates sympathetic hyperactivity, offering a potential target for managing autonomic ...
Maoxing Fei +7 more
wiley +1 more source
Cool executive functions and their association with body mass & fatness and the FTO gene in school-aged children. [PDF]
Sci Rep, 2023 Szcześniewska P +8 more
europepmc +1 more source
Clinical Epigenomics in Rare Diseases: Interpreting DNA Methylation Episignatures
Molecular Genetics &Genomic Medicine, Volume 14, Issue 10, October 2026.Clinical epigenomics extends rare‐disease diagnostics beyond DNA sequence by revealing the downstream regulatory consequences of genetic variation. DNA methylation episignatures provide functional evidence that can support diagnosis, refine variant interpretation, distinguish overlapping disorders, and complement genomic, and multi‐omic testing ...
Himanshu Goel, Shuxiang Goh, Luke Stuart
wiley +1 more source
Lack of association of the alpha-ketoglutarate-dependent dioxygenase (FTO) gene polymorphisms with pulmonary tuberculosis risk: a systematic review and meta-analysis. [PDF]
Ann Med Surg (Lond), 2023 Lamichhane P +7 more
europepmc +1 more source
Obesity, Volume 34, Issue 10, Page 1967-1978, October 2026.ABSTRACT Objective BMI is widely used to define obesity and may not capture heterogeneity in body fat distribution. Genetic studies of obesity have largely focused on BMI but not visceral fat and fat‐free mass, which is particularly limited in East Asian populations.
Hsin‐Ming Lu +5 more
wiley +1 more source
Phytotherapy Research, Volume 40, Issue 10, Page 6005-6042, October 2026.The translational research framework integrating TCM for RA. The figure outlines a stepwise framework for the modernization and clinical translation of TCM in RA. Part 1 highlights the inheritance and development of TCM theory, including classical medical texts, traditional herbal knowledge, and syndrome differentiation–based treatment principles. Part
Jianting Wen +4 more
wiley +1 more source
Small Science, Volume 6, Issue 10, October 2026.Heavy‐metal‐free chalcogenide nanocrystals are a nontoxic alternative for next‐generation optoelectronic applications. This review provides a comprehensive overview of their unique optical properties, surface chemistry, and their performance in photodetectors, solar cells, light‐emitting diodes, and photocatalytic systems.
Apurba Mahapatra +7 more
wiley +1 more source
The effects of FTO gene rs9939609 polymorphism on the association between breast cancer and dietary intake. [PDF]
J Cell Mol Med, 2022 Doaei S +16 more
europepmc +1 more source