Results 111 to 120 of about 7,322,114 (249)

Cooperativity of Glucocorticoid Response Elements Located Far Upstream of the Tyrosine Aminotransferase Gene [PDF]

, 1987
Two glucocorticoid response elements (GREs) located 2.5 kb upstream of the transcription initiation site of the tyrosine aminotransferase gene were identified by gene transfer experiments and shown to bind to purified glucocorticoid receptor.
Banerji, Becker, Becker, Buetti, Cartwright, Chandler, Chen, Church, DeFranco, Gilbert, Gluecksohn-Waelsch, Gorman, Granner, Greengard, Hargrove, Hashimoto, Hochschild, Hynes, Karin, Karin, Killary, Maniatis, Maxam, Melton, Miksicek, Payvar, Pelham, Ptashne, Renkawitz, Ringold, Ruiz-Bravo, Scheidereit, Scherer, Schmid, Searle, Serfling, Sergeant, Singh, Slater, Yamamoto, Zaret, Zinn   +41 more
core   +1 more source

Association between fat mass and obesity associated (FTO) gene rs9939609 A/T polymorphism and polycystic ovary syndrome: a systematic review and meta-analysis

BMC Medical Genetics, 2017
BackgroundUp to now, numerous case-control studies have reported the associations between fat mass and obesity associated (FTO) gene rs9939609 A/T polymorphism and polycystic ovary syndrome (PCOS), however, without a consistent result. Hence we performed
A. Liu, Hui Xie, Hong-yan Xie, Jun Liu, Jie Yin, Jingyan Hu, C. Peng   +6 more
semanticscholar   +1 more source

Beyond Deterministic Fetal Programming: Intrauterine Exposures and the Multifactorial Origins of Adiposity

Obesity Reviews, EarlyView.
ABSTRACT Excess adiposity is not a recently developed problem but has existed since at least the upper Paleolithic, allowing evolutionary selection pressures to adapt the physiology of the pregnant woman and the feto‐placental unit for maternal and fetal protection.
Gernot Desoye, Ursula Hiden, Evelyn Jantscher‐Krenn, Herbert Fluhr, Jonathan C. Wells, Sonja Entringer, Mireille N. M. van Poppel   +6 more
wiley   +1 more source

Assessment of the FTO gene polymorphisms inmale patients with metabolic syndrome [PDF]

Advances in Clinical and Experimental Medicine, 2018
Accumulating evidence indicates the potential involvement of the FTO gene polymorphisms in the etiology of metabolic syndrome (MetS) and related disorders.In this study, we aimed to investigate whether the FTO gene polymorphisms are associated with the risk of MetS and its simple components in a homogeneous sample of males.Anthropometric and ...
Ryszard, Ślęzak, Przemysław, Leszczyński, Magdalena, Warzecha, Łukasz, Łaczmański, Błażej, Misiak   +4 more
openaire   +3 more sources

FTO Inhibits Insulin Secretion and Promotes NF-κB Activation through Positively Regulating ROS Production in Pancreatic β cells.

PLoS ONE, 2015
FTO (Fat mass and obesity-associated) is associated with increased risk of obesity and type 2 diabetes incurrence. Pancreas islet β cells dysfunction and insulin resistance are major causes of type 2 diabetes.
Hong-Qi Fan, Wei He, Kuan-Feng Xu, Zhi-Xiao Wang, Xin-Yu Xu, Heng Chen   +5 more
doaj   +1 more source

Assessing effect of interaction between the FTO A/T polymorphism (rs9939609) and physical activity on obesity-related traits

Journal of Sport and Health Science, 2018
Background: The first described obesity-susceptibility gene was the fat mass and obesity-associated (FTO) gene. However, knowledge about FTO's potential modifying effect on changes in body weight achieved through a training program is still limited.
Agata Leońska-Duniec, Zbigniew Jastrzębski, Aleksandra Zarębska, Agnieszka Maciejewska, Krzysztof Ficek, Paweł Cięszczyk   +5 more
doaj   +1 more source

The association between FTO gene polymorphism rs9939609 and obesity is sex-specific in the population of PURE study in Poland.

Advances in Clinical and Experimental Medicine, 2020
BACKGROUND Fat mass and obesity-associated gene (FTO) polymorphism remains the strongest known genetic determinant of common obesity. However, its influence depends on ethnicity, and the FTO-mediated predisposition to other metabolic disturbances is ...
A. Zdrojowy-Wełna, G. Bednarek-Tupikowska, K. Zatońska, K. Kolačkov, Alicja Jokiel-Rokita, M. Bolanowski   +5 more
semanticscholar   +1 more source

StALKBH10B‐Mediated RNA m6A Modification Inhibits Potato Salt Tolerance by Targeting Flavonoids and ABA Signalling Pathways

Plant Biotechnology Journal, EarlyView.
ABSTRACT N6‐methyladenosine (m6A) is the most prevalent methylation modification present in mRNAs, which has been confirmed to participate in many developmental and biological processes. However, the biological function and specific regulatory mechanism of m6A modification in relation to salt tolerance of potato remain obscure.
Xuanming Dong, Jianyu Ma, Chenxin Sui, Yan Li, Vadim Khassanov, Hongju Jian, Dianqiu Lv   +6 more
wiley   +1 more source

Association of FTO Gene Variant (rs8050136) with Type 2 Diabetes and Markers of Obesity, Glycaemic Control and Inflammation

Journal of Medical Biochemistry, 2019
Summary Background FTO, a gene recently discovered in genomewide associated studies for type 2 diabetes mellitus (T2D), play an important role in the management of energy homeostasis, nucleic acid demethylation and regulation of body fat mass by ...
T. Bego, A. Causevic, T. Dujic, M. Malenica, Z. Velija-Ašimi, B. Prnjavorac, J. Marc, J. Nekvindová, V. Palička, S. Semiz   +9 more
semanticscholar   +1 more source

Hypoxia and hypercapnia elicit overlapping but distinct skeletal muscle toxicities

The Journal of Physiology, EarlyView.
Abstract figure legend Hypoxia and hypercapnia cause overlapping skeletal muscle phenotypes, including atrophy, change in myofibre metabolic profile and myogenic response to injury. Both signals operate via distinct cellular pathways. Abstract Skeletal muscle dysfunction is strongly associated with elevated mortality in acute and chronic pulmonary ...
Joseph Balnis, Ariel Jaitovich
wiley   +1 more source