Results 11 to 20 of about 7,322,114 (249)

Involvement of an FTO gene polymorphism in the temporomandibular joint osteoarthritis. [PDF]

Clin Oral Investig, 2022
The FTO gene has been reported as an obesity-associated gene and is also considered a risk gene for osteoarthritis (OA). However, its exact function is unclear, and there is conflicting evidence on the involvement of FTO polymorphisms in OA via obesity ...
Takaoka R, Kuyama K, Yatani H, Ishigaki S, Kayashima H, Koishi Y, Kato T, Egusa H, Uchiyama Y, Nakatani A, Shimamoto H.   +10 more
europepmc   +5 more sources

The IRX3 Gene; the Missing Link between the FTO Gene and Obesity

Asian Pacific Journal of Cancer Biology, 2016
Aims: The aim of this study was the investigation of the mediator role of the IRX3 gene in the relationship between the FTO gene and obesity. Materials and Methods: All related articles published in English from June 1990 to February 2017 were studied ...
Saeid Doaei, Maryam Gholamalizadeh, Alireza Mousavi Jarrahi, Marjan Badakhanian, Rahim Najafi   +4 more
doaj   +4 more sources

Changes in gene expression associated with FTO overexpression in mice.

PLoS ONE, 2014
Single nucleotide polymorphisms in the first intron of the fat-mass-and-obesity-related gene FTO are associated with increased body weight and adiposity. Increased expression of FTO is likely underlying this obesity phenotype, as mice with two additional
Myrte Merkestein, James S McTaggart, Sheena Lee, Holger B Kramer, Fiona McMurray, Mathilde Lafond, Lily Boutens, Roger Cox, Frances M Ashcroft   +8 more
doaj   +5 more sources

Role of rs9939506 polymorphism of FTO gene in resistance to eating in male adolescents [PDF]

BMC Pediatrics, 2023
Background Single Nucleotide Polymorphisms (SNPs) of the Fat mass and obesity-associated (FTO) gene may be associated with obesity by regulating appetite.
Ali Shaker, Soheila Shekari, Mobina Zeinalabedini, Zahra Salimi, Zahra Roumi, Khadijeh Abbasi Mobarakeh, Ali Shamsi-Goushki, Mohammad Masoumvand, Mohammad Keshavarz Mohammadian, Pegah Samani, Ghasem Azizi-Tabesh, Hanieh Shafaei, Saeid Doaei, Naser Kalantari, Maryam Gholamalizadeh   +14 more
doaj   +2 more sources

Interactions of anthropometric indices, rs9939609 FTO gene polymorphism and breast cancer: A case-control study. [PDF]

J Cell Mol Med, 2021
Contradictory results were reported on the effect of fat mass‐ and obesity‐associated (FTO) gene and anthropometric measurements on breast cancer (BC). This study aimed to assess the interactions between rs9939609 polymorphism of FTO gene, anthropometric
Doaei S, Bourbour F, Rastgoo S, Akbari ME, Gholamalizadeh M, Hajipour A, Moslem A, Ghorat F, Badeli M, Bagheri SE, Alizadeh A, Mokhtari Z, Pishdad S, JavadiKooshesh S, Azizi Tabesh G, Montazeri F, Joola P, Rezaei S, Dorosti M, Mosavi Jarrahi SA.   +19 more
europepmc   +2 more sources

Interactions between macro-nutrients’ intake, FTO and IRX3 gene expression, and FTO genotype in obese and overweight male adolescents [PDF]

Adipocyte, 2019
This study is the first to identify the effects of FTO genotype on the interactions between the level of macro-nutrients intake and the expression level of fat mass and obesity associated (FTO) and homeobox transcription factor iriquois-3 (IRX3) genes ...
Saeid Doaei, Naser Kalantari, Pantea Izadi, Tuire Salonurmi, Alireza Mosavi Jarrahi, Shahram Rafieifar, Ghasem Azizi Tabesh, Ghazaleh Rahimzadeh, Maryam Gholamalizadeh, Mark O. Goodarzi   +9 more
doaj   +3 more sources

The effect of rs9930506 FTO gene polymorphism on obesity risk: a meta-analysis

Biomolecular Concepts, 2019
Obesity is associated with polymorphisms of the fat mass and obesity associated gene (FTO). This meta-analysis aimed to investigate the association of the rs9930506 FTO gene polymorphism and obesity.
Doaei S, Mosavi Jarrahi SA, Sanjari Moghadam A, Akbari ME, Javadi Kooshesh S, Badeli M, Azizi Tabesh Gh, Abbas Torki S, Gholamalizadeh M, Zhu ZH, Montazeri F, Mirzaei Dahka S   +11 more
doaj   +2 more sources

Fat Mass and Obesity-Related (FTO) Gene Variant Is a Predictor of CVD in T2DM Patients [PDF]

Journal of Diabetes Research
Conclusion: The FTO gene variant rs9939609 has a strong association with T2DM and CVD. The AA genotype of FTO gene variants rs9939609 showed a strong association with most of the risk factors of CVD and T2DM.
Mazhar Hussain, Akbar Waheed, Asim Elahi, Ghulam Mustafa   +3 more
doaj   +2 more sources

The bigger picture of FTO—the first GWAS-identified obesity gene [PDF]

Nature Reviews Endocrinology, 2013
Single nucleotide polymorphisms (SNPs) that cluster in the first intron of fat mass and obesity associated (FTO) gene are associated obesity traits in genome-wide association studies. The minor allele increases BMI by 0.39 kg/m(2) (or 1,130 g in body weight) and risk of obesity by 1.20-fold.
Loos, Ruth J. F., Yeo, Giles S. H.
openaire   +4 more sources

Relationship of FTO gene variations with NAFLD risk in Chinese men

Open Life Sciences, 2020
Fat mass and obesity-associated (FTO) gene is an obesity susceptibility gene and its relationship with the nonalcoholic fatty liver disease (NAFLD) remains unclear.
Chen Xuefen, Gao Yong, Yang Xiaobo, Zhang Haiying, Mo Zengnan, Tan Aihua   +5 more
doaj   +3 more sources