Results 51 to 60 of about 2,096 (161)
Implications of Genetic Elements on Type 2 Diabetes Mellitus Pathogenesis and Management
Endocrinology, Diabetes &Metabolism, Volume 9, Issue 2, March 2026.Genetic variations in T2DM, including key metabolic and insulin‐related genes, influence disease risk, insulin resistance, and drug response. Understanding these polymorphisms enables precision medicine, optimising therapy and improving glycaemic control across diverse populations.
Nokwanda N. Ngcobo, Ntethelelo H. Sibiya
wiley +1 more source
Lifestyle Genomics, 2023 Introduction: Single-nucleotide polymorphism (SNP) rs9939609 in the FTO gene has been associated with dietary intake and appetite traits, mainly in participants with obesity; however, it remains widely unexplored in normal weight participants.
Andrea Madrigal-Juarez +7 more
doaj +1 more source
Food Frontiers, Volume 7, Issue 2, March 2026.The Mediterranean diet interacts with genetic and epigenetic backgrounds to modulate nutrigenomic mechanisms, including DNA methylation, histone modification and microRNA regulation. These molecular effects reduce inflammation and oxidative stress, enhance nitric oxide bioavailability and lipid metabolism and translate into improved cardiometabolic ...
Karina Ramírez‐Alarcón +16 more
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Medicine, 2017 The fat mass and obesity-associated (FTO) rs9939609 polymorphism have been associated with the increased metabolic risk and mortality, irrespective of obesity. The mechanism underlying this association is not known. We aimed to evaluate whether the FTO rs9939609 risk variant is independently associated with metabolic risk factors and/or leukocyte ...
Yu, Ji Hee +9 more
openaire +3 more sources
Diabetes, Obesity and Metabolism, Volume 28, Issue 3, Page 1661-1672, March 2026.Abstract Aims Precision nutrition, guided by genetic testing, has emerged as a promising approach for managing obesity. However, robust clinical trials testing its effectiveness in real‐world dietary interventions remain scarce. The GenOn Programme aims to evaluate whether tailoring nutritional care based on genetic risk for obesity enhances weight ...
Karla P. Balbino +11 more
wiley +1 more source
Common variants of FTO are associated with childhood obesity in a cross-sectional study of 3,126 urban Indian children. [PDF]
PLoS ONE, 2012 FTO variants are robustly associated with obesity and related traits in many population and shown to have variable impact during life course. Although studies have shown association of FTO variants with adiposity in adult Indian, its association in ...
Om Prakash Dwivedi +6 more
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The Intersection of m6A Methylation and Immune Response in PCOS: A Bioinformatics Perspective
Immunity, Inflammation and Disease, Volume 14, Issue 2, February 2026.N6‐methyladenosine RNA methylation regulators are intricately linked with the development of polycystic ovary syndrome (PCOS) and may influence immune cell infiltration in affected individuals. This study enhances our understanding of the molecular interactions in PCOS and suggests potential biomarkers for diagnosis and targets for therapeutic ...
Wenting Xu +8 more
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Correlates of the FTO Gene Variant (rs9939609) and Growth of American Indian Infants [PDF]
Genetic Testing and Molecular Biomarkers, 2011 Obesity is a global, growing public-health problem. The detrimental health consequences of obesity are significant and include co-morbidities such as diabetes, coronary heart disease, and some types of cancer. To date, findings relating the A allele of the FTO variant rs9939609 to increased energy intake and risk for obesity have been fairly consistent
Nuananong, Seal +2 more
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Clinical Epidemiology and Global HealthBackground: The FTO gene polymorphisms rs9939609 have been linked to obesity. It’s essential to note that genetic variations exist between different populations.
Ricvan Dana Nindrea +1 more
doaj +1 more source
Mitigation of Metabolic Diseases Through Personalized Nutrition: A Critical In‐Depth Review
Food Science &Nutrition, Volume 14, Issue 1, January 2026.The main objective of this review is to explore the impact of variation within the microbiome and among genes on nutrient metabolism and argue in favor of successful evidence of individualized dietary intervention for cardiovascular disease, diabetes, and obesity.
Muhammad Tayyab Arshad +7 more
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