Results 71 to 80 of about 2,096 (161)

Uncovering the Causal Link Between Obesity‐Associated Genes and Multiple Sclerosis: A Systematic Literature Review

Brain and Behavior, Volume 15, Issue 4, April 2025.
This systematic literature review explores the influence of six obesity‐associated genes on multiple sclerosis (MS) risk and progression, revealing significant genetic underpinnings and potential pathways for MS pathogenesis and treatment. ABSTRACT Background: Multiple sclerosis (MS) is a multifaceted neurodegenerative disorder influenced by genetics ...
Ali Jafari, Sara Khoshdooz, Melika Arab Bafrani, Farnush Bakhshimoghaddam, Hamid Abbasi, Saeid Doaei   +5 more
wiley   +1 more source

A Decade of the Common FTO Rs9939609 Polymorphism: A Systematic Review

Collegium antropologicum, 2018
Several association studies focusing on FTO gene polymorphisms have been published in the past years; however, the association between FTO-related conditions and FTO gene variants remains unexplained. Population genetics and association studies of different populations provide a valuable tool for further research.
Baručija-Özçoban, Indira, Ašić, Adna, Bešić, Larisa, Halilović, Sabina, Marjanović, Damir, Dogan, Serkan   +5 more
openaire   +2 more sources

Fat Mass and Obesity-Related (FTO) Gene Variant Is a Predictor of CVD in T2DM Patients

Journal of Diabetes Research
Conclusion: The FTO gene variant rs9939609 has a strong association with T2DM and CVD. The AA genotype of FTO gene variants rs9939609 showed a strong association with most of the risk factors of CVD and T2DM.
Mazhar Hussain, Akbar Waheed, Asim Elahi, Ghulam Mustafa   +3 more
doaj   +1 more source

Association of Omentin rs2274907 and FTO rs9939609 gene polymorphisms with insulin resistance in Iranian individuals with newly diagnosed type 2 diabetes

Lipids in Health and Disease, 2019
Background Insulin resistance (IR) and fat accumulation in visceral adipose tissue are key players in developing type 2 diabetes (T2D). Several adipose tissue derived-gene polymorphisms are related to higher body mass index (BMI), insulin resistance and ...
Amirhosein Khoshi, Mehdi Kaffash Bajestani, Habibesadat Shakeri, Golnaz Goodarzi, Fatemeh Azizi   +4 more
doaj   +1 more source

Association between fat mass and obesity associated (FTO) gene rs9939609 A/T polymorphism and polycystic ovary syndrome: a systematic review and meta-analysis

BMC Medical Genetics, 2017
Background Up to now, numerous case-control studies have reported the associations between fat mass and obesity associated (FTO) gene rs9939609 A/T polymorphism and polycystic ovary syndrome (PCOS), however, without a consistent result.
Ai Ling Liu, Hui Jun Xie, Hong Yan Xie, Jun Liu, Jie Yin, Jin Song Hu, Cui Ying Peng   +6 more
doaj   +1 more source

[The study of FTO rs9939609-gene polymorphism in the Sverdlovsk Region].

Voprosy pitaniia, 2013
Recently independent studies, including genome-wide scans, have shown that the rs9939609 single-nucleotide polymorphism (SNP) in the first intron of the fat mass and obesity associated (FTO) gene were significantly associated with obesity in populations of European origin, in certain Asian (e.g.,Japanese and Chinese) and African American populations ...
A K, Baturin, E Iu, Sorokina, A V, Pogozheva, O V, Anokhina, V A, Tutel'ian   +4 more
openaire   +1 more source

Rs9939609 Variant of the Fat Mass and Obesity-Associated Gene and Trunk Obesity in Adolescents

Journal of Obesity, 2011
A common T/A polymorphism (rs9939609) in the fat mass and obesity associated (FTO) gene was found associated with early-onset and severe obesity in both adults and children. However, recent observations failed to find associations of FTO with obesity. To investigate the genetic background of early obesity, we analysed the single nucleotide polymorphism
Harald Mangge, Wilfried Renner, Gunter Almer, Daniel Weghuber, Reinhard Möller, Renate Horejsi   +5 more
openaire   +3 more sources

Fat phenotype, associated factors and rs9939609 polymorphism of the FTO gene

Revista Brasileira de Cineantropometria e Desempenho Humano, 2010
The purpose of this work was to review the main results of studies that have analysed the relationship between the rs9939609 single nucleotide polymorphism (SNP) of the FTO gene and the manifestation of overweight/obesity with its associated co-morbidity,
William Alves Lima, Maria Fátima Glaner, Aline Pic Taylor   +2 more
doaj   +1 more source

Metabolic biomarkers in patients with type 2 diabetes mellitus and heart failure with preserved ejection fraction

Сахарный диабет
BACKGROUND: Half of all patients with chronic heart failure (CHF) have preserved ejection fraction (CHF-nEF). The drug’s use effective for treatment of CHF with reduced ejection fraction (CHF-nFV) reduces the hospitalization incidence but does not affect
T. S. Sveklina, S. B. Shustov, S. N. Kolyubayeva, A. N. Kuchmin, V. A. Kozlov, E. V. Smirnova, A. V. Zharkov   +6 more
doaj   +1 more source

Effect of the rs9939609-FTO marker in Mexican adults under nutritional intervention

Revista Mexicana de Endocrinología, Metabolismo y Nutrición
Background: Obesity is a disease importantly influenced by genetic factors. The rs9939609 variant of the gene associated with fat mass and obesity (FTO) has been associated with weight gain, body mass index (BMI), and influence on the individual response
Diana A. Vela-Vásquez, Ivan Delgado-Enciso, Gilberto Ruiz-de-la-Cruz, Pascuala Ambriz-Morales, Ana Ma. Sifuentes-Rincón   +4 more
doaj   +1 more source