Results 81 to 90 of about 4,732 (207)

Minor alleles of FTO rs9939609 and rs17817449 polymorphisms confer a higher risk of type 2 diabetes mellitus and dyslipidemia, but not coronary artery disease in a Chinese Han population

Frontiers in Endocrinology, 2023
BackgroundRelationships of the polymorphisms in fat mass and obesity-associated gene (FTO) and peroxisome proliferator-activated receptor delta gene (PPARD) with metabolic-related diseases remain to be clarified.MethodsOne thousand three hundred and ...
Youjin Zhang, Lvlin Chen, Junchen Zhu, Hao Liu, Luying Xu, Yang Wu, Chuan He, Yongyan Song   +7 more
doaj   +1 more source

A Systematic Mapping Approach of 16q12.2/FTO and BMI in More Than 20,000 African Americans Narrows in on the Underlying Functional Variation: Results from the Population Architecture using Genomics and Epidemiology (PAGE) Study [PDF]

, 2013
Genetic variants in intron 1 of the fat mass- and obesity-associated (FTO) gene have been consistently associated with body mass index (BMI) in Europeans.
A Adeyemo, A Hinney, A Scuteri, AL Price, Aleksandar Rajkovic, B Howie, B Howie, BF Voight, BJ Hennig, C Cotsapas, C Dina, C. Charles Gu, CA McKenzie, Charles Kooperberg, Christopher A. Haiman, CJ Willer, CJ Willer, Cora E. Lewis, D Meyre, Dana C. Crawford, Denise Houston, EK Speliotes, F Renstrom, Fred Schumacher, G Stratigopoulos, G Thorleifsson, Georg Ehret, Iona Cheng, Jeff Haessler, JP Higgins, JT Tan, K Wang, KA Frazer, Kari E. North, Keri Monda, KF Adams, Khanh-Dung H. Nguyen, KM Flegal, Lew H. Kuller, LN Kolonel, Loic Le Marchand, Lucia A. Hindorff, Lynne Wilkens, Marguerite R. Irvin, Mark I. McCarthy, Mark Leppert, Marylyn Ritchie, MC Ng, ME Weale, Megan D. Fesinmeyer, MR Wing, MR Wing, MT Hassanein, N Patterson, NL Nock, P Sethupathy, Petra Buzkova, Praveen Sethupathy, R DerSimonian, R Dorajoo, RC Deo, Rebecca D. Jackson, Richard Cooper, RJ Loos, RJ Pruim, RM Durbin, Rongling Li, S Bollepalli, S Buyske, S Jiao, S Levy, S Omori, SA Al-Attar, SC Gorber, SF Grant, Shuo Jiao, SR Browning, Steve Buyske, SW Cha, Tara C. Matise, TC Matise, TM Frayling, TY Li, Ulrike Peters, Unhee Lim, WJ Kent, Y Song, YAA Liu, YC Chang   +88 more
core   +8 more sources

Coevolution of Human Diet and Gut Microbiome: Implications for Nutrigenomics and Cross‐Population Health

International Journal of Microbiology, Volume 2026, Issue 1, 2026.
The coevolution of the human diet and gut microbiome has played a pivotal role in shaping metabolic, immune, and epigenetic functions across human history. Dietary transitions from high‐fiber ancestral patterns to modern ultraprocessed diets have markedly influenced microbial diversity and functionality, contributing to the emergence of chronic ...
Ferry Sandra, Alifah Evi Scania, Nurrani Mustika Dewi, Dewi Ranggaini, Johni Halim, Alfred Pakpahan, Kyung Hoon Lee, Shrikant Bhute   +7 more
wiley   +1 more source

The FTO rs9939609 polymorphism is associated with short leukocyte telomere length in nonobese individuals

Medicine, 2017
The fat mass and obesity-associated (FTO) rs9939609 polymorphism have been associated with the increased metabolic risk and mortality, irrespective of obesity. The mechanism underlying this association is not known. We aimed to evaluate whether the FTO rs9939609 risk variant is independently associated with metabolic risk factors and/or leukocyte ...
Yu, Ji Hee, Baik, Inkyung, Cho, Hyun Joo, Seo, Ji A., Kim, Sin Gon, Choi, Kyung Mook, Baik, Sei Hyun, Choi, Dong Seop, Shin, Chol, Kim, Nan Hee   +9 more
openaire   +3 more sources

Physical activity attenuates the influence of FTO variants on obesity risk: A meta-analysis of 218,166 adults and 19,268 children [PDF]

, 2011
Background: The FTO gene harbors the strongest known susceptibility locus for obesity. While many individual studies have suggested that physical activity (PA) may attenuate the effect of FTO on obesity risk, other studies have not been able to confirm ...
Ahmad, T. (Tariq), Amin, N. (Najaf), Atalay, M. (Mustafa), Autenrieth, C.S. (Christine), Balkau, B. (Beverley), Bandinelli, S. (Stefania), Bergmann, S.M. (Sven), Boehnke, M. (Michael), Boeing, H. (Heiner), Borecki, I.B. (Ingrid), Bouchard, C. (Claude), Brage, S. (Soren), Bragg-Gresham, J.L. (Jennifer L.), Cauchi, S. (Stephane), Cavalcanti-Proença, C. (Christine), Chasman, D.I. (Daniel), Dedoussis, G.V. (George), Demerath, E.W. (Ellen), Ebrahim, S. (Shanil), Ekelund, U. (Ulf), Feitosa, M.F. (Mary Furlan), Ferrucci, L. (Luigi), Florez, J.C. (Jose), Franks, P.W. (Paul), Fritsche, A. (Andreas), Froguel, P. (Philippe), Fu, M. (Mao), Garcia, M. (Melissa), Groop, L. (Leif), Grøntved, A. (Anders), Gudnason, V. (Vilmundur), Hakanen, M. (Maarit), Hallmans, G. (Göran), Hansen, T. (Torben), Harris, T.B. (Tamara), He, M. (Meian), Hofman, A. (Albert), Holzapfel, C. (Christina), Hu, F.B. (Frank), Hyppönen, E. (Elina), Illig, T. (Thomas), Isomaa, B. (Bo), Jablonski, K.A. (Kathleen), Jansson, J.O., Johansson, S. (Stefan), Järvelin, M.R., Kaakinen, M. (Marika), Kanoni, S. (Stavroula), Khaw, K.-T., Kilpeläinen, T.O. (Tuomas), Kumari, M. (Meena), Kutalik, Z. (Zoltán), Kuusisto, J. (Johanna), Kähönen, M. (Mika), Laakso, M. (Markku), Lakka, T.A. (Timo), Larrad, M.T.M., Lawlor, D.A. (Debbie), Lehtimäki, T. (Terho), Liu, S. (Simin), Loos, R.J.F. (Ruth), Lutsey, P.L. (Pamela), Mangino, M. (Massimo), Marmot, M. (Michael), Meidtner, K. (Karina), Meirhaeghe, A. (Aline), Metter, J. (Jeffery), Mohlke, K.L. (Karen), Monda, K.L. (Keri), Mora, S. (Samia), Ness, A.R. (Andrew), Njolstad, P. (Pal), Nolan, J.J. (John), Ohlsson, C. (Claes), Onland-Moret, N.C. (Charlotte), Orho-Melander, M. (Marju), Palla, L. (Luigi), Pedersen, O. (Oluf), Power, C. (Chris), Pérusse, L. (Louis), Qi, L. (Lu), Raitakari, O. (Olli), Renström, F. (Frida), Ridker, P.M. (Paul), Rios, M.S., Rivera, N.V. (Natalia), Ruiz, J.R. (Jonatan), Rönnemaa, T. (Tapani), Sandholt, C. (Camilla), Scott, R.A. (Robert), Sharp, S.J. (Stephen), Shungin, D. (Dmitry), Silbernagel, G. (Günther), Snitker, S. (Soren), Sonestedt, E. (Emily), Song, Y. (Yiqing), Sovio, U. (Ulla), Spector, T.D. (Timothy), Stancáková, A. (Alena), Stringham, H.M. (Heather), Sørensen, T.I.A. (Thorkild), Tai, E.S. (Shyong), Tammelin, T.H. (Tuija), Tan, J.T. (Jonathan), Tanaka, T. (Toshiko), Tikka-Kleemola, P. (Päivi), Timpson, N.J. (Nicholas), Tuomilehto, J. (Jaakko), Uitterlinden, A.G. (André), Uusitupa, M. (Matti), Vliet-Ostaptchouk, J.V. (Jana) van, Walker, M. (Mark), Wareham, N.J. (Nick), Wu, Y. (Ying), Zillikens, M.C. (Carola), Zimmermann, E. (Esther)   +115 more
core   +1 more source

Identification of dyslipidemia genes : genetics and molecular biology [PDF]

, 2010
New approaches to determine which common genetic variants may be responsible for lipid disorders within the wider population particularly the association between clinical phenotype and single nucleotide polymorphisms (SNPs) or genetic loci in multiple ...
Dandona, Doney, Frayling, Girelli, Kathiresan, Keebler, Lloyd-Jones, Luft, Naoumova, Pirruccello, Samani, Voicik, Zhao   +12 more
core   +1 more source

The Genetic Blueprint of Obesity: From Pathogenesis to Novel Therapies

Obesity Reviews, Volume 26, Issue 12, December 2025.
ABSTRACT Obesity is a chronic metabolic disease characterized by disturbances in energy homeostasis, leading to excessive fat accumulation. The pathogenesis of the disease is shaped by a complex interplay of genetic, epigenetic, biological, psychological, and environmental factors.
Gašper Tonin, Stjepan Eržen, Zala Mlinarič, Dubravka Jurišić Eržen, Simon Horvat, Tanja Kunej, Jasna Klen   +6 more
wiley   +1 more source

Genetic Predictors of Weight Loss and Weight Regain After Intensive Lifestyle Modification, Metformin Treatment, or Standard Care in the Diabetes Prevention Program [PDF]

, 2012
OBJECTIVE: We tested genetic associations with weight loss and weight regain in the Diabetes Prevention Program, a randomized controlled trial of weight loss–inducing interventions (lifestyle and metformin) versus placebo.
Delahanty, Linda M., Florez, Jose C., Franks, Paul,, Jablonski, Icatiileen A., Kahn, Steven E., Knowler, William C., Lund University., Lund University., Lund University., McCaffery, Jeanne M., Pan, Qing, Shuldiner, Alan, Watson, Karol E.   +12 more
core   +1 more source

Role of FTO in adipocyte development and function: recent insights [PDF]

, 2015
In 2007, FTO was identified as the first genome-wide association study (GWAS) gene associated with obesity in humans. Since then, various animal models have served to establish the mechanistic basis behind this association.
Merkestein, Myrte, Sellayah, Dyan
core   +2 more sources

Multi‐Omics Analysis Reveals Causal Relationships and Potential Mediators Between Dietary Preferences and Risk of NAFLD

Food Science &Nutrition, Volume 13, Issue 6, June 2025.
This study combines Mendelian randomization, co‐localization, and clinical cross‐sectional analyses to reveal that preferences for fruit juice and soft cheese have opposite causal effects on NAFLD risk, mediated by the FTO gene. Moreover, low‐calorie dietary preferences reduce NAFLD risk through up‐regulation of inflammatory protein DNER.
Qingan Fu, Jierui Liu, Zhekang Liu, Tianzhou Shen, Qingyun Yu, Huangxin Zhu, Shisheng Wu, Rixiang Liu, Deju Zhang, Xiao Liu, Xiaoping Yin, Jianping Liu, Yanze Wu, Jing Zhang, Peng Yu   +14 more
wiley   +1 more source