Results 61 to 70 of about 2,096 (161)

Association of rs9939609 FTO Gene Polymorphism as a Risk Factor of Obesity in Adults

GHMJ (Global Health Management Journal)
Background: The cause of obesity is an imbalance between the number of calories taken and the amount burned. Obesity is a complex disease. The FTO rs9939609 gene polymorphism is one of the genetic factors that contribute to obesity in addition to ...
Tiar Masykuroh Pratamawati, Angel Angriani Elma Budai Sadji, Gara Samara Brajadenta, Donny Nauphar   +3 more
doaj   +1 more source

Association Study of rs1421085 and rs9939609 in FTO Gene with Gestational Diabetes in the Arak City [PDF]

Majallah-i dānishgāh-i ̒ulūm-i pizishkī-i Arāk
Introduction: Gestational diabetes is defined as hyperglycemia with onset or first diagnosis during pregnancy, with a lower frequency than general diabetes.
Parnian Hekmatpou, Maryam Maryam Ghanbari, Milad Gholami   +2 more
doaj  

Age- and sex-dependent association between FTO rs9939609 and obesity-related traits in Chinese children and adolescents. [PDF]

PLoS ONE, 2014
The associations between common variants in the fat mass- and obesity-associated (FTO) gene and obesity-related traits may be age-dependent and may differ by sex.
Meixian Zhang, Xiaoyuan Zhao, Hong Cheng, Liang Wang, Bo Xi, Yue Shen, Dongqing Hou, Jie Mi   +7 more
doaj   +1 more source

Association of rs9939609 of the FTO Gene with Obesity Phenotypes in Women

Doctor.Ru
Aim. To study the association of rs9939609 of the FTO gene with various obesity phenotypes, its individual parameters, and some risk factors in a sample of women Design. Cross-sectional cohort study. Materials and methods. The study was conducted on the basis of the population sample of the HAPIEE project, the age of the participants was — 45–69 ...
V.N. Maksimov, S.V. Michin, Yu.V. Ivanova, E.S. Shabanova, O.D. Rymar, S.K. Malyutina   +5 more
openaire   +1 more source

The FTO gene polymorphism rs9939609 is associated with obesity and disability in multiple sclerosis patients [PDF]

Scientific Reports, 2019
AbstractObesity is a well-known risk factor for multiple diseases including multiple sclerosis (MS). Polymorphisms in the fat-mass obesity (FTO) gene have been consistently found to be associated with obesity, and recently found to increase the risk of developing MS.
Al-Serri, Ahmad, Alroughani, Raed, Al-Temaimi, Rabeah A.   +2 more
openaire   +2 more sources

The Genetic Blueprint of Obesity: From Pathogenesis to Novel Therapies

Obesity Reviews, Volume 26, Issue 12, December 2025.
ABSTRACT Obesity is a chronic metabolic disease characterized by disturbances in energy homeostasis, leading to excessive fat accumulation. The pathogenesis of the disease is shaped by a complex interplay of genetic, epigenetic, biological, psychological, and environmental factors.
Gašper Tonin, Stjepan Eržen, Zala Mlinarič, Dubravka Jurišić Eržen, Simon Horvat, Tanja Kunej, Jasna Klen   +6 more
wiley   +1 more source

The FTO gene rs9939609 obesity-risk allele and loss of control over eating [PDF]

The American Journal of Clinical Nutrition, 2009
Children with rs9939609 FTO variant alleles (homozygous = AA and heterozygous = AT) are predisposed to greater adiposity than are those with 2 wild-type alleles (TT).Because FTO is highly expressed in hypothalamic regions that are important for appetite, FTO genotype may affect energy balance by influencing eating behavior. Loss of control (LOC) eating,
Marian, Tanofsky-Kraff, Joan C, Han, Kavitha, Anandalingam, Lauren B, Shomaker, Kelli M, Columbo, Laura E, Wolkoff, Merel, Kozlosky, Camden, Elliott, Lisa M, Ranzenhofer, Caroline A, Roza, Susan Z, Yanovski, Jack A, Yanovski   +11 more
openaire   +2 more sources

Association Between Industrialized Dietary Pattern and Cardiometabolic Risk Factors in Children With FTO RS9939609 Gene Polymorphism

Molecular Nutrition &Food Research, Volume 69, Issue 22, November 2025.
This study examined how dietary patterns affect health in children aged 4–7 years, especially in the presence of the fat mass and obesity associated (FTO) gene polymorphism. Researchers found that children with FTO gene polymorphism who ate more industrialized foods had higher risks of health problems and cardiometabolic risk with higher values of the ...
Bhreendda’ Hary Dy Luar Prates Kiepper, Francilene Maria Azevedo, Aline Carare Candido, Mariane Alves Silva, Juliana Farias de Novaes, Cristina Maria Mendes Resende, Danielle Fernandes Durso, Jacqueline Isaura Alvarez‐Leite, Gustavo Velasquez‐Melendez, Sylvia do Carmo Castro Franceschini, Eliana Carla Gomes de Souza, Sarah Aparecida Vieira Ribeiro   +11 more
wiley   +1 more source

The common rs9939609 variant of the fat mass and obesity-associated gene is associated with obesity risk in children and adolescents of Beijing, China

BMC Medical Genetics, 2010
Background Previous genome-wide association studies for type 2 diabetes susceptibility genes have confirmed that a common variant, rs9939609, in the fat mass and obesity associated (FTO) gene region is associated with body mass index (BMI) in European ...
Lindpaintner Klaus, Hou Dongqing, Cheng Hong, Wu Lijun, Zhao Xiaoyuan, Liu Xin, Zhang Meixian, Shen Yue, Xi Bo, Liu Lisheng, Mi Jie, Wang Xingyu   +11 more
doaj   +1 more source

Multi‐Omics Analysis Reveals Causal Relationships and Potential Mediators Between Dietary Preferences and Risk of NAFLD

Food Science &Nutrition, Volume 13, Issue 6, June 2025.
This study combines Mendelian randomization, co‐localization, and clinical cross‐sectional analyses to reveal that preferences for fruit juice and soft cheese have opposite causal effects on NAFLD risk, mediated by the FTO gene. Moreover, low‐calorie dietary preferences reduce NAFLD risk through up‐regulation of inflammatory protein DNER.
Qingan Fu, Jierui Liu, Zhekang Liu, Tianzhou Shen, Qingyun Yu, Huangxin Zhu, Shisheng Wu, Rixiang Liu, Deju Zhang, Xiao Liu, Xiaoping Yin, Jianping Liu, Yanze Wu, Jing Zhang, Peng Yu   +14 more
wiley   +1 more source