Results 1 to 10 of about 1,103 (148)

Genetic Associations of TCF7L2 (rs7903146) and PPARG (rs1801282) with Prediabetes in the Ethnic Kazakh Population [PDF]

Diagnostics
Background: This study aims to investigate the genetic contribution of polymorphic variants of the TCF7L2 (rs7903146) and PPARG (rs1801282) genes to the risk of developing prediabetes in individuals of Kazakh ethnicity.
Azhar Dyussupova, Gulnara Svyatova, Galina Berezina, Altay Dyussupov, Bauyrzhan Omarkulov, Anastassiya Dzharmukhametova, Oxana Yurkovskaya, Venera Akhmetova, Asylzhan Dyussupova   +8 more
doaj   +4 more sources

Genetic influence of PPAR-γ rs1801282 and MTRR rs162036 variants on non-small cell lung cancer risk in Egyptians [PDF]

Discover Oncology
Background Lung cancer remains the leading cause of cancer-related deaths worldwide. Despite advances in diagnostics and treatment, most patients are diagnosed at advanced stages.
Yomna F. Metwally, Rasha F. Zahran, Rana R. El Sadda, Sherif Refaat, Afaf M. Elsaid   +4 more
doaj   +3 more sources

Association between PPARγ rs1801282 polymorphism with diabetic nephropathy and type-2 diabetes mellitus susceptibility in south India and a meta-analysis

Nefrologia, 2020
Background: Diabetic Nephropathy (DN) is a major complication of Type 2 Diabetes Mellitus (T2DM) with high morbidity rates worldwide. Objective: To determine the association of PPARγ rs1801282 polymorphism in T2DM and DN in south Indian population ...
Veerabathiran Ramakrishnan
exaly   +7 more sources

Metabolic Biomarkers in Adults with Type 2 Diabetes: The Role of PPAR-γ2 and PPAR-β/δ Polymorphisms [PDF]

Biomolecules, 2023
Glucose and lipid metabolism regulation by the peroxisome proliferator-activated receptors (PPARs) has been extensively reported. However, the role of their polymorphisms remains unclear.
Sandra A. Reza-López, Susana González-Gurrola, Oscar O. Morales-Morales, Janette G. Moreno-González, Ana M. Rivas-Gómez, Everardo González-Rodríguez, Verónica Moreno-Brito, Angel Licón-Trillo, Irene Leal-Berumen   +8 more
doaj   +2 more sources

Relationship between PPAR‐γ gene polymorphisms and ischemic stroke risk: A meta‐analysis

Brain and Behavior, 2021
Background Published researches have suggested some associations between PPAR‐γ and ischemic stroke (IS) development. This meta‐analysis was conducted to evaluate the association between PPAR‐γ gene polymorphisms and IS risk.
Fan Cheng, Xiao‐Min Si, Gong‐Li Yang, Lan Zhou   +3 more
doaj   +2 more sources

Implications of Genetic Elements on Type 2 Diabetes Mellitus Pathogenesis and Management. [PDF]

Endocrinol Diabetes Metab
Genetic variations in T2DM, including key metabolic and insulin‐related genes, influence disease risk, insulin resistance, and drug response. Understanding these polymorphisms enables precision medicine, optimising therapy and improving glycaemic control across diverse populations.
Ngcobo NN, Sibiya NH.
europepmc   +2 more sources

G Allele of the rs1801282 Polymorphism in PPARγ Gene Confers an Increased Risk of Obesity and Hypercholesterolemia, While T Allele of the rs3856806 Polymorphism Displays a Protective Role Against Dyslipidemia: A Systematic Review and Meta-Analysis

Frontiers in Endocrinology, 2022
BackgroundThe relationships between the rs1801282 and rs3856806 polymorphisms in nuclear receptor peroxisome proliferator-activated receptor gamma (PPARγ) gene and obesity indexes as well as serum lipid levels have been extensively investigated in ...
Chuan He, Song Yongyan
exaly   +3 more sources

PPARγ Variant rs10865710 and Mortality in Pediatric Septic Shock Stratified by Corticosteroid Exposure [PDF]

Critical Care Explorations
OBJECTIVES:. To determine whether genetic variation in peroxisome proliferator-activated receptor gamma (PPARγ) is associated with mortality across corticosteroid exposure strata in pediatric septic shock. DESIGN:.
Valentina Bonnefil, Stephen Standage, Andrew J. Lautz, Natalja L. Stanski, Kelli Harmon, Patrick Lahni, Julie C. Fitzgerald, Adam J. Schwarz, Neal J. Thomas, Bereketeab Haileselassie, Basilia Zingarelli, Jennifer M. Kaplan, Mihir R. Atreya, for the Sepsis Genomics Collaborative   +13 more
doaj   +2 more sources

Associations Between TCF7L2, PPARγ, and KCNJ11 Genotypes and Insulin Response to an Oral Glucose Tolerance Test: A Systematic Review. [PDF]

Mol Nutr Food Res
No robust evidence for associations between TCF7L2, PPARγ, or KCNJ11 genotypes and postprandial insulin AUC after an oral glucose tolerance test (OGTT) was found. ABSTRACT Scope: Insulin responses to standardized meals differ between individuals. This variability may in part be explained by genotype.
Blanken CPS, Bayer S, Buchner Carro S, Hauner H, Holzapfel C.   +4 more
europepmc   +2 more sources

Effects of PPARG and PPARGC1A gene polymorphisms on obesity markers [PDF]

Frontiers in Public Health, 2022
Pediatric obesity presents a multifactorial etiology, which involves genetic traits as well, including single nucleotide polymorphisms. The aim of the study is to investigate the contribution of PPARG gene polymorphisms (namely Pro12Ala rs1801282 ...
Carmen Muntean, Maria Oana Sasaran, Adriana Crisan, Claudia Banescu   +3 more
doaj   +2 more sources