G Allele of the rs1801282 Polymorphism in PPARγ Gene Confers an Increased Risk of Obesity and Hypercholesterolemia, While T Allele of the rs3856806 Polymorphism Displays a Protective Role Against Dyslipidemia: A Systematic Review and Meta-Analysis [PDF]
Frontiers in Endocrinology, 2022 BackgroundThe relationships between the rs1801282 and rs3856806 polymorphisms in nuclear receptor peroxisome proliferator-activated receptor gamma (PPARγ) gene and obesity indexes as well as serum lipid levels have been extensively investigated in ...
Chuan He
exaly +4 more sources
Metabolic Biomarkers in Adults with Type 2 Diabetes: The Role of PPAR-γ2 and PPAR-β/δ Polymorphisms [PDF]
Biomolecules, 2023 Glucose and lipid metabolism regulation by the peroxisome proliferator-activated receptors (PPARs) has been extensively reported. However, the role of their polymorphisms remains unclear.
Sandra A. Reza-López +8 more
doaj +2 more sources
Nefrologia, 2020 Background: Diabetic Nephropathy (DN) is a major complication of Type 2 Diabetes Mellitus (T2DM) with high morbidity rates worldwide. Objective: To determine the association of PPARγ rs1801282 polymorphism in T2DM and DN in south Indian population ...
Shiek Ssj
exaly +7 more sources
Association of FTO and PPARG polymorphisms with obesity in Portuguese women [PDF]
Diabetes, Metabolic Syndrome and Obesity, 2013 Fábio Ferreira Carlos,1,2 José Silva-Nunes,3,4 Orfeu Flores,1 Miguel Brito,3 Gonçalo Doria,1 Luísa Veiga,3 Pedro Viana Baptista1 1Centro de Investigação em Genética Molecular Humana, Universidade Nova de ...
Ferreira Carlos F +6 more
doaj +3 more sources
Genetic Associations of TCF7L2 (rs7903146) and PPARG (rs1801282) with Prediabetes in the Ethnic Kazakh Population [PDF]
DiagnosticsBackground: This study aims to investigate the genetic contribution of polymorphic variants of the TCF7L2 (rs7903146) and PPARG (rs1801282) genes to the risk of developing prediabetes in individuals of Kazakh ethnicity.
Azhar Dyussupova +8 more
doaj +2 more sources
Effects of PPARG and PPARGC1A gene polymorphisms on obesity markers [PDF]
Frontiers in Public Health, 2022 Pediatric obesity presents a multifactorial etiology, which involves genetic traits as well, including single nucleotide polymorphisms. The aim of the study is to investigate the contribution of PPARG gene polymorphisms (namely Pro12Ala rs1801282 ...
Carmen Muntean +3 more
doaj +2 more sources
Genetic Predisposition to Prediabetes in the Kazakh Population [PDF]
Current Issues in Molecular BiologyThe aim of this study was to conduct a comparative analysis of the population frequencies of the minor allele of polymorphic variants in the genes TCF7L2 (rs7903146) and PPARG (rs1801282), based on the genome-wide association studies analysis data ...
Gulnara Svyatova +6 more
doaj +2 more sources
Association between PPARγ, PPARGC1A, and PPARGC1B genetic variants and susceptibility of gastric cancer in an Eastern Chinese population [PDF]
BMC Medical Genomics, 2022 Purpose Previous studies showed that peroxisome proliferator-activated receptor gamma (PPARγ) and PPARγ coactivator1 family (PPARGC1A and PPARGC1B) gene single nucleotide variants (SNVs)were strongly associated with cancer susceptibility.
Boyang Chen +6 more
doaj +2 more sources
PPARγ Gene Polymorphisms, Metabolic Disorders, and Coronary Artery Disease [PDF]
Frontiers in Cardiovascular Medicine, 2022 Being activated by endogenous and exogenous ligands, nuclear receptor peroxisome proliferator-activated receptor gamma (PPARγ) enhances insulin sensitivity, promotes adipocyte differentiation, stimulates adipogenesis, and has the properties of anti ...
Yongyan Song, Shujin Li, Chuan He
doaj +2 more sources
The Analysis of ECE1 and PPARG Variants in the Development of Osteopenia and Osteoporosis in Postmenopausal Women [PDF]
BiomedicinesOsteoporosis is a multifactorial systemic skeletal disease that is characterized by a low bone mineral density (BMD) and the microarchitectural deterioration of bone tissue, leading to bone fragility.
Izabela Uzar +8 more
doaj +2 more sources