Results 1 to 10 of about 1,303 (153)

Implications of Genetic Elements on Type 2 Diabetes Mellitus Pathogenesis and Management. [PDF]

Endocrinol Diabetes Metab
Genetic variations in T2DM, including key metabolic and insulin‐related genes, influence disease risk, insulin resistance, and drug response. Understanding these polymorphisms enables precision medicine, optimising therapy and improving glycaemic control across diverse populations.
Ngcobo NN, Sibiya NH.
europepmc   +2 more sources

Relationship between PPAR‐γ gene polymorphisms and ischemic stroke risk: A meta‐analysis

Brain and Behavior, Volume 11, Issue 12, December 2021., 2021
Ischemic strokes (IS) are one of the most common diseases resulting in disabilities and death among adults. Our meta‐analysis indicated that the individuals with G mutation of rs1801282 C/G polymorphism would face an increased risk of IS. But there was no significant association between rs3856806 C/T polymorphism and IS risk.
Fan Cheng, Xiao‐Min Si, Gong‐Li Yang, Lan Zhou   +3 more
wiley   +2 more sources

Associations Between TCF7L2, PPARγ, and KCNJ11 Genotypes and Insulin Response to an Oral Glucose Tolerance Test: A Systematic Review. [PDF]

Mol Nutr Food Res
No robust evidence for associations between TCF7L2, PPARγ, or KCNJ11 genotypes and postprandial insulin AUC after an oral glucose tolerance test (OGTT) was found. ABSTRACT Scope: Insulin responses to standardized meals differ between individuals. This variability may in part be explained by genotype.
Blanken CPS, Bayer S, Buchner Carro S, Hauner H, Holzapfel C.   +4 more
europepmc   +2 more sources

Genetic variants associated with weight loss and metabolic outcomes after bariatric surgery: A systematic review

Obesity Reviews, Volume 24, Issue 12, December 2023., 2023
Summary The extent to which genetic variations contribute to interindividual differences in weight loss and metabolic outcomes after bariatric surgery is unknown. Identifying genetic variants that impact surgery outcomes may contribute to clinical decision making.
Rieneke van der Meer, Siham A. Mohamed, Valerie M. Monpellier, Ronald S. L. Liem, Eric J. Hazebroek, Paul W. Franks, Timothy M. Frayling, Ignace M. C. Janssen, Mireille J. Serlie   +8 more
wiley   +1 more source

Development of a prediction protocol for the screening of metabolic associated fatty liver disease in children with overweight or obesity

Pediatric Obesity, Volume 17, Issue 9, September 2022., 2022
Summary Background The early detection and management of children with metabolic associated fatty liver disease (MAFLD) is challenging. Objective To develop a non‐invasive and accurate prediction protocol for the identification of MAFLD among children with overweight/obesity candidates to confirmatory diagnosis.
Maddi Oses, Cristina Cadenas‐Sanchez, María Medrano, Arkaitz Galbete, Emiliano Miranda‐Ferrua, Jonatan R. Ruiz, Felix Sánchez‐Valverde, Francisco B. Ortega, Rafael Cabeza, Arantxa Villanueva, Fernando Idoate, Idoia Labayen   +11 more
wiley   +1 more source

Mitochondrial haplogroups have a better correlation to insulin requirement than nuclear genetic variants for type 2 diabetes mellitus in Taiwanese individuals

Journal of Diabetes Investigation, Volume 13, Issue 1, Page 201-208, January 2022., 2022
Mitochondrial haplogroups, but not nuclear genetic variants, have a better association with the insulin requirement in patients with T2DM. ABSTRACT Aims/Introduction Identifying diabetes‐susceptible genetic variants will help to provide personalized therapy for the management of type 2 diabetes. Previous studies have reported a genetic risk score (GRS),
Feng‐Chih Shen, Shao‐Wen Weng, Meng‐Han Tsai, Yu‐Jih Su, Sung‐Chou Li, Shun‐Jen Chang, Jung‐Fu Chen, Yen‐Hsiang Chang, Chia‐Wei Liou, Tsu‐Kung Lin, Jiin‐Haur Chuang, Ching‐Yi Lin, Pei‐Wen Wang   +12 more
wiley   +1 more source

Molecular Dynamics Simulation and Essential Dynamics of Deleterious Proline 12 Alanine Single‐Nucleotide Polymorphism in PPARγ2 Associated with Type 2 Diabetes, Cardiovascular Disease, and Nonalcoholic Fatty Liver Disease

PPAR Research, Volume 2022, Issue 1, 2022., 2022
Background. Peroxisome proliferator‐activated receptor‐γ (PPARγ) gene is located at 3p25 position. PPARγ functions as the master regulator of glucose homeostasis and lipoprotein metabolism, and recent studies have reported that it is involved in various metabolic diseases such as diabetes mellitus, hyperlipidemia, coronary artery disease (CAD), and ...
Somayye Taghvaei, Leila Saremi, Nguan Soon Tan   +2 more
wiley   +1 more source

Association between Genetic Polymorphisms and Risk of Kidney Posttransplant Diabetes Mellitus: A Systematic Review and Meta‐Analysis

International Journal of Clinical Practice, Volume 2022, Issue 1, 2022., 2022
Objectives. The purpose of this study was to clarify the role of genetic factors on posttransplant diabetes mellitus (PTDM) risk. Methods. Relevant publications were systematically retrieved from PubMed, EMBASE, and the Cochrane Library up to December 2020.
Shan Xu, Zhenwei Jiang, Nan Hu, Ahmed Abdelwahab   +3 more
wiley   +1 more source

Genome‐wide association analysis of serum alanine and aspartate aminotransferase, and the modifying effects of BMI in 388k European individuals

Genetic Epidemiology, Volume 45, Issue 6, Page 664-681, September 2021., 2021
Abstract Serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) are biomarkers for liver health. Here we report the largest genome‐wide association analysis to date of serum ALT and AST levels in over 388k people of European ancestry from UK biobank and DiscovEHR. Eleven million imputed markers with a minor allele frequency (MAF) ≥ 0.
Chuan Gao, Anthony Marcketta, Joshua D. Backman, Colm O'Dushlaine, Jeffrey Staples, Manuel Allen Revez Ferreira, Luca A. Lotta, John D. Overton, Jeffrey G. Reid, Tooraj Mirshahi, Regeneron Genetics Center, Geisinger Regeneron Discovehr Collaboration, Aris Baras, Gonçalo Abecasis, Alan R. Shuldiner, Cristopher V. Van Hout, Shane McCarthy   +16 more
wiley   +1 more source

Pro12Ala polymorphism of peroxisome proliferator activated receptor gamma 2 may be associated with adverse neurodevelopment in European preterm babies

Brain and Behavior, Volume 11, Issue 8, August 2021., 2021
Abstract Introduction Prematurity is the leading cause of death and disability in children under 5 years of age. Understanding the molecular mechanisms of the biological processes involved in preterm brain injury may help develop novel neuroprotective treatment strategies.
Suresh Victor, Andrew Chew, Shona Falconer   +2 more
wiley   +1 more source