Results 31 to 40 of about 2,006 (194)

Association between Genetic Polymorphisms and Risk of Kidney Posttransplant Diabetes Mellitus: A Systematic Review and Meta‐Analysis

International Journal of Clinical Practice, Volume 2022, Issue 1, 2022., 2022
Objectives. The purpose of this study was to clarify the role of genetic factors on posttransplant diabetes mellitus (PTDM) risk. Methods. Relevant publications were systematically retrieved from PubMed, EMBASE, and the Cochrane Library up to December 2020.
Shan Xu, Zhenwei Jiang, Nan Hu, Ahmed Abdelwahab   +3 more
wiley   +1 more source

Genome‐wide association analysis of serum alanine and aspartate aminotransferase, and the modifying effects of BMI in 388k European individuals

Genetic Epidemiology, Volume 45, Issue 6, Page 664-681, September 2021., 2021
Abstract Serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) are biomarkers for liver health. Here we report the largest genome‐wide association analysis to date of serum ALT and AST levels in over 388k people of European ancestry from UK biobank and DiscovEHR. Eleven million imputed markers with a minor allele frequency (MAF) ≥ 0.
Chuan Gao, Anthony Marcketta, Joshua D. Backman, Colm O'Dushlaine, Jeffrey Staples, Manuel Allen Revez Ferreira, Luca A. Lotta, John D. Overton, Jeffrey G. Reid, Tooraj Mirshahi, Regeneron Genetics Center, Geisinger Regeneron Discovehr Collaboration, Aris Baras, Gonçalo Abecasis, Alan R. Shuldiner, Cristopher V. Van Hout, Shane McCarthy   +16 more
wiley   +1 more source

Impact of Proliferator-Activated Receptor γ Gene Polymorphisms on Risk of Schizophrenia: A Case-Control Study and Computational Analyses

Iranian Journal of Psychiatry, 2020
Objective: Schizophrenia (SCZ) is a common psychiatric disorder characterized by a complex mode of inheritance. Peroxisome proliferator-activated receptor-γ (PPARG) mainly regulates lipid and glucose metabolisms while it is constitutively expressed in ...
Saman Sargazi, Fariba Mirani Sargazi, Mahdiyeh Moudi, Milad Heidari Nia, Ramin Saravani, Shekoufeh Mirinejad, Sheida Shahraki, Mansoor Shakiba   +7 more
doaj   +1 more source

Pro12Ala polymorphism of peroxisome proliferator activated receptor gamma 2 may be associated with adverse neurodevelopment in European preterm babies

Brain and Behavior, Volume 11, Issue 8, August 2021., 2021
Abstract Introduction Prematurity is the leading cause of death and disability in children under 5 years of age. Understanding the molecular mechanisms of the biological processes involved in preterm brain injury may help develop novel neuroprotective treatment strategies.
Suresh Victor, Andrew Chew, Shona Falconer   +2 more
wiley   +1 more source

Leveraging genetic ancestry to study health disparities

American Journal of Physical Anthropology, Volume 175, Issue 2, Page 363-375, June 2021., 2021
Abstract Research to understand human genomic variation and its implications in health has great potential to contribute in the reduction of health disparities. Biological anthropology can play important roles in genomics and health disparities research using a biocultural approach.
Ken Batai, Stanley Hooker, Rick A. Kittles   +2 more
wiley   +1 more source

Clinical and genetic characteristics of patients with obesity and non-alcoholic fatty liver disease

Gastroenterologìa, 2020
Backgrounds. Currently, the rs1801282 (Pro12Ala) polymorphism in PPAR-γ2 (peroxisome proliferator-activated receptor gamma) gene is important for the pathogenesis of both obesity and non-alcoholic fatty liver disease (NAFLD).
V.P. Shypulin, N.N. Rudenko, A.K. Koliada, N.Н. Melnyk   +3 more
doaj   +1 more source

Sex and Menopause Modify the Effect of Single Nucleotide Polymorphism Genotypes on Fibrosis in NAFLD

Hepatology Communications, Volume 5, Issue 4, Page 598-607, April 2021., 2021
The development of fibrosis in nonalcoholic fatty liver disease (NAFLD) is influenced by genetics, sex, and menopausal status, but whether genetic susceptibility to fibrosis is influenced by sex and reproductive status is unclear. Our aim was to identify metabolism‐related single nucleotide polymorphisms (SNPs), whose effect on NAFLD fibrosis is ...
Kara Wegermann, Melanie E. Garrett, Jiayin Zheng, Andrea Coviello, Cynthia A. Moylan, Manal F. Abdelmalek, Shein‐Chung Chow, Cynthia D. Guy, Anna Mae Diehl, Allison Ashley‐Koch, Ayako Suzuki   +10 more
wiley   +1 more source

Variants of the human PPARG locus and the susceptibility to chronic periodontitis [PDF]

, 2011
Apart from its regulatory function in lipid and glucose metabolism, peroxisome proliferator-activated receptor (PPAR)γ has impact on the regulation of inflammation and bone metabolism.
Desvergne B, Excoffier L, Glas J, Loos BG, Miller SA, Nyman S   +5 more
core   +1 more source

The PPARγ2 P12A polymorphism is not associated with all-cause mortality in patients with type 2 diabetes mellitus [PDF]

, 2016
The high mortality risk of patients with type 2 diabetes mellitus may well be explained by the several comorbidities and/or complications. Also the intrinsic genetic component predisposing to diabetes might have a role in shaping the risk of diabetes ...
Alberico, Federica, Bacci, Simonetta, Cignarelli, Mauro, Copetti, Massimiliano, De Cosmo, Salvatore, Fontana, Andrea, Lamacchia, Olga, Marucci, Antonella, Mercuri, Luana, Pacilli, Antonio, Palena, Antonio, Prudente, Sabrina, Trischitta, Vincenzo, Viti, Raffaella   +13 more
core   +1 more source

Associations of molecular genetic predictors of type 2 diabetes mellitus with hyperglycemia in extremely low birth weight infants

Вестник анестезиологии и реаниматологии, 2021
Hyperglycemia in premature newborns is an independent risk factor for death, so blood glucose testing is widely used in the practice of neonatal intensive care units.Objective: to evaluate the associations of the frequency of carriage of allelic variants
P. I. Mironov, N. N. Mingazov, R. R. Valiev, А. U. Lekmanov   +3 more
doaj   +1 more source