Results 31 to 40 of about 1,103 (148)
Iranian Journal of Psychiatry, 2020 Objective: Schizophrenia (SCZ) is a common psychiatric disorder characterized by a complex mode of inheritance. Peroxisome proliferator-activated receptor-γ (PPARG) mainly regulates lipid and glucose metabolisms while it is constitutively expressed in ...
Saman Sargazi +7 more
doaj +1 more source
Genetic Epidemiology, Volume 45, Issue 6, Page 664-681, September 2021., 2021 Abstract Serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) are biomarkers for liver health. Here we report the largest genome‐wide association analysis to date of serum ALT and AST levels in over 388k people of European ancestry from UK biobank and DiscovEHR. Eleven million imputed markers with a minor allele frequency (MAF) ≥ 0.
Chuan Gao +16 more
wiley +1 more source
Brain and Behavior, Volume 11, Issue 8, August 2021., 2021 Abstract Introduction Prematurity is the leading cause of death and disability in children under 5 years of age. Understanding the molecular mechanisms of the biological processes involved in preterm brain injury may help develop novel neuroprotective treatment strategies.
Suresh Victor +2 more
wiley +1 more source
Clinical and genetic characteristics of patients with obesity and non-alcoholic fatty liver disease
Gastroenterologìa, 2020 Backgrounds. Currently, the rs1801282 (Pro12Ala) polymorphism in PPAR-γ2 (peroxisome proliferator-activated receptor gamma) gene is important for the pathogenesis of both obesity and non-alcoholic fatty liver disease (NAFLD).
V.P. Shypulin +3 more
doaj +1 more source
Leveraging genetic ancestry to study health disparities
American Journal of Physical Anthropology, Volume 175, Issue 2, Page 363-375, June 2021., 2021 Abstract Research to understand human genomic variation and its implications in health has great potential to contribute in the reduction of health disparities. Biological anthropology can play important roles in genomics and health disparities research using a biocultural approach.
Ken Batai +2 more
wiley +1 more source
Sex and Menopause Modify the Effect of Single Nucleotide Polymorphism Genotypes on Fibrosis in NAFLD
Hepatology Communications, Volume 5, Issue 4, Page 598-607, April 2021., 2021 The development of fibrosis in nonalcoholic fatty liver disease (NAFLD) is influenced by genetics, sex, and menopausal status, but whether genetic susceptibility to fibrosis is influenced by sex and reproductive status is unclear. Our aim was to identify metabolism‐related single nucleotide polymorphisms (SNPs), whose effect on NAFLD fibrosis is ...
Kara Wegermann +10 more
wiley +1 more source
Вестник анестезиологии и реаниматологии, 2021 Hyperglycemia in premature newborns is an independent risk factor for death, so blood glucose testing is widely used in the practice of neonatal intensive care units.Objective: to evaluate the associations of the frequency of carriage of allelic variants
P. I. Mironov +3 more
doaj +1 more source
The Effect of PPARγ rs1801282 Variant on Mortality Risk Among Asians With Chronic Kidney Disease: A Cohort Study and Meta-Analysis [PDF]
Frontiers in Genetics, 2022 Background: Chronic kidney disease (CKD) is a public health issue, and an independent risk factor for cardiovascular disease. The peroxisome proliferator-activated receptor gamma (PPARG) plays an important role in the cardiovascular system. Previous studies have examined one important exon polymorphism, Pro12Ala, in PPARG with respect to mortality of ...
Wei-Teing Chen +14 more
openaire +3 more sources
Neural Regeneration Research, 2019 Two common polymorphisms of the peroxisome proliferator-activated receptor gamma (PPARG) gene, rs1801282 and rs3856806, may be important candidate gene loci affecting the susceptibility to ischemic stroke.
Yan-Zhe Wang +5 more
doaj +1 more source
Biology of Sport, 2021 Peroxisome proliferator-activated receptors (PPARs) have unique functions in energy metabolism regulation but are also involved in regulation of the inflammatory process and obesity.
Ewelina Maculewicz +14 more
doaj +1 more source