Results 11 to 20 of about 1,303 (153)

Genetic Associations of TCF7L2 (rs7903146) and PPARG (rs1801282) with Prediabetes in the Ethnic Kazakh Population. [PDF]

Diagnostics (Basel)
Background: This study aims to investigate the genetic contribution of polymorphic variants of the TCF7L2 (rs7903146) and PPARG (rs1801282) genes to the risk of developing prediabetes in individuals of Kazakh ethnicity. Materials and Methods: This was a case-control study involving 200 cases with prediabetes and 200 prediabetes-free controls, aged 16 ...
Dyussupova A, Svyatova G, Berezina G, Dyussupov A, Omarkulov B, Dzharmukhametova A, Yurkovskaya O, Akhmetova V, Dyussupova A.   +8 more
europepmc   +5 more sources

Clinical effect of thiazolidinediones in subjects with disorders of carbohydrate metabolism in case of polymorphism rs1801282 [PDF]

Obesity and metabolism, 2020
BACKGROUND: The polymorphism rs1801282 (Pro12Ala) may be one of the reasons for the heterogeneous response of patients with carbohydrate metabolism disorders to thiazolidinedione therapy. Studies of this polymorphism in patients with metabolic syndrome (MS) will help identify a group of patients in whom the use of thiazolidinedione is advisable. AIMS:
Tatyana V. Eremenko, Nikolay A. Matsievskiy, Natalya V. Vorokhobina, Irina Y. Matesius, Irina N. Abramashvili   +4 more
openaire   +4 more sources

THE RS1801282 PPARG POLYMORPHISM DEPENDENT METABOLIC EFFECTS OF PIOGLITAZONE IN PATIENTS WITH OBESITY AND CONCOMITANT NAFLD [PDF]

EUREKA: Health Sciences, 2020
The aim: to investigate the metabolic effects of different treatment options in patients with obesity and concomitant non-alcoholic fatty liver disease (NAFLD) based on the presence of CG and GG genotypes PPARG rs1801282 (Pro12Ala) polymorphism in Ukrainians.
Vadym Shypulin, Nikolai Rudenko, Oleksandr Martynchuk, Aleksandr Koliada, Vitaly Guryanov, Nataliia Melnyk   +5 more
openaire   +4 more sources

Changes in body composition depending on the rs1801282 PPARG polymorphism in patients with different variants of treatment of early carbohydrate metabolism disorders [PDF]

Medical Herald of the South of Russia, 2021
Objective: To study the effect of the rs1801282 PPARG polymorphism on changes in the body composition of patients with early carbohydrate metabolism disorders in groups with different variants of treatment.Materials and Methods: The study involved 64 patients (8 men and 56 women) with early carbohydrate metabolism disorders.
F. V. Valeeva, M. S. Medvedeva, K. B. Khasanova, T. S. Turtseva, T. S. Yilmaz   +4 more
openaire   +4 more sources

Is the rs1801282 (G/C) Polymorphism of PPAR - Gamma Gene Associated with T2DM in Iraqi People? [PDF]

Open Access Macedonian Journal of Medical Sciences, 2018
BACKGROUND: Pro12Ala (rs1801282) is a common polymorphism of the human PPAR-γ gene. Studies have demonstrated conflicting results about its association with T2DM worldwide. There are no reports about such possible association among Iraqi people. OBJECTIVES:  This study aims at finding out whether having the mutant allele (Ala12) might be associated ...
Al-Naemi, Amjad Hazim, Ahmad, Akram Jarjees   +1 more
core   +5 more sources

Polymorphisms FTO rs9939609, PPARG rs1801282 and ADIPOQ rs4632532 and rs182052 but not lifestyle are associated with obesity related-traits in Mexican children [PDF]

Genetics and Molecular Biology, 2016
Concerning the genetic factors of obesity, no consistent association between populations has been reported, which may be due to the frequency of polymorphisms, the lifestyle of studied populations and its interaction with other factors. We studied a possible association of polymorphisms FTO rs9939609, PPARG rs1801282, and ADIPOQ rs4632532 and rs182052 ...
Muñoz-Yáñez, C, Pérez-Morales, R, Moreno-Macías, H, Calleros-Rincón, E, Ballesteros, G, González, R. A, Espinosa, J   +6 more
core   +8 more sources

Polymorphisms of the PPAR-γ(rs1801282) and Its Coactivator (rs8192673) Have a Minor Effect on Markers of Carotid Atherosclerosis in Patients with Type 2 Diabetes Mellitus [PDF]

PPAR Research, 2016
Background. The present study was designed to clarify whether common single nucleotide polymorphisms (SNPs) of the Peroxisome Proliferator-Activated Receptor-γ(PPAR-γ) gene (rs1801282) and the Peroxisome Proliferator-Activated Receptor-γCoactivator-1 (PGC-1α) gene (rs8192673) are associated with markers of carotid and coronary atherosclerosis in ...
Aleš Pleskovič, Marija Šantl Letonja, Andreja Cokan Vujkovac, Jovana Nikolajević Starćević, Danijel Petrovič   +4 more
openaire   +5 more sources

Metabolic Biomarkers in Adults with Type 2 Diabetes: The Role of PPAR-γ2 and PPAR-β/δ Polymorphisms. [PDF]

Biomolecules, 2023
Glucose and lipid metabolism regulation by the peroxisome proliferator-activated receptors (PPARs) has been extensively reported. However, the role of their polymorphisms remains unclear.
Reza-López SA, González-Gurrola S, Morales-Morales OO, Moreno-González JG, Rivas-Gómez AM, González-Rodríguez E, Moreno-Brito V, Licón-Trillo A, Leal-Berumen I.   +8 more
europepmc   +2 more sources

Association of PPARγ (rs1801282) and TCF7L2 (rs7903146) gene polymorphisms and susceptibility of Type 1 diabetes mellitus in Egyptian children. [PDF]

J Genet Eng Biotechnol
Mahmoud NH, Abdel-Hakem NE, Ghanoum RAEA, Ghanem AI, Ali YBM.   +4 more
europepmc   +2 more sources

Association of polimorphism rs1801282 with different components of the metabolic syndrome

HERALD of North-Western State Medical University named after I.I. Mechnikov, 2018
Objective. To study the association of polymorphism rs1801282 of the PPARγ gene with different components of metabolic syndrome (MS). Materials and methods. 145 subjects with newly diagnosed MS were examined. All subjects underwent a clinical examination, including general clinical, laboratory and instrumental methods; presence of polymorphism ...
T V Eremenko, S M Kotova, I Yu Matezius, F K Khetagurova, F M Radugin   +4 more
openaire   +4 more sources