Results 21 to 30 of about 1,103 (148)

Genetic markers of cardiac autonomic neuropathy in the Kazakh population [PDF]

BMC Cardiovascular Disorders
Background Cardiac autonomic neuropathy (CAN) is a complication of diabetes mellitus (DM) that increases the risk of morbidity and mortality by disrupting cardiac innervation.
Nazira Bekenova, Ainur Sibagatova, Alisher Aitkaliyev, Tamara Vochshenkova, Balzhan Kassiyeva, Valeriy Benberin   +5 more
doaj   +2 more sources

Differences between Aqueous Humor and Serum Concentrations of BDNF and PPARG Genetic Variants in Glaucoma Patients [PDF]

Acta Clinica Croatica
Brain-derived neurotrophic factor (BDNF) is essential for neuronal development, differentiation and survival, and aberrant BDNF expression in retina is associated with glaucoma.
Tena Križ, Mia Zorić Geber, Ana Merkler Šorgić, Ana Kozmar, Katia Novak-Lauš, Zoran Vatavuk, Jadranka Sertić   +6 more
doaj   +2 more sources

Gene sequence variants PPARGC1Ars8192678, PPARG2rs1801282, FTORS9939609, LEPRS7799039 and LEPRRS1137101 in non-alcoholic fatty liver disease [PDF]

Saratov Medical Journal, 2023
Objective: assessing the association of sequence variants rs8192678, rs1801282, rs9939609, rs7799039 and rs1137101in PPARGC1A, PPARG2, FTO, LEP and LEPR genes, respectively,with non-alcoholic fatty liver disease (NAFLD) inyounger adults (18-44 years ...
Pankova, Ekaterina D. , Chulkov, Vasiliy S. , Gavrilova, Elena S. , Zotova, Maria A. , Sumerkina, Veronika A. , Zhmaylova, Svetlana V. , Okonenko, Tatiana I.   +6 more
doaj   +1 more source

Genetic variants associated with weight loss and metabolic outcomes after bariatric surgery: A systematic review

Obesity Reviews, Volume 24, Issue 12, December 2023., 2023
Summary The extent to which genetic variations contribute to interindividual differences in weight loss and metabolic outcomes after bariatric surgery is unknown. Identifying genetic variants that impact surgery outcomes may contribute to clinical decision making.
Rieneke van der Meer, Siham A. Mohamed, Valerie M. Monpellier, Ronald S. L. Liem, Eric J. Hazebroek, Paul W. Franks, Timothy M. Frayling, Ignace M. C. Janssen, Mireille J. Serlie   +8 more
wiley   +1 more source

ASSOCIATION ANALYSIS OF PIOGLITAZONE EFFECTIVENESS IN TREATMENT OF NAFLD PATIENTS WITH OBESITY AND PPARG RS1801282 (PRO12ALA) GENOTYPE

Wiadomości Lekarskie, 2021
The aim: To study the association between the effectiveness of treatment with pioglitazone non-alcoholic fatty liver disease (NAFLD) in patients with obesity and PPARG rs1801282 (Pro12Ala)-polymorphism in Ukrainians. Materials and methods: 123 patients with NAFLD in combination with obesity 1, 2, 3 classes were included in comprehensive weight loss ...
Vadym P, Shypulin, Oleksandr A, Martynchuk, Nikolai N, Rudenko, Aleksandr K, Koliada, Viktoriia V, Tishchenko, Nataliia H, Melnyk   +5 more
openaire   +2 more sources

Association of polimorphism rs1801282 with different components of the metabolic syndrome

HERALD of North-Western State Medical University named after I.I. Mechnikov, 2018
Objective. To study the association of polymorphism rs1801282 of the PPARγ gene with different components of metabolic syndrome (MS). Materials and methods. 145 subjects with newly diagnosed MS were examined. All subjects underwent a clinical examination, including general clinical, laboratory and instrumental methods; presence of polymorphism ...
T V Eremenko, S M Kotova, I Yu Matezius, F K Khetagurova, F M Radugin   +4 more
openaire   +4 more sources

Development of a prediction protocol for the screening of metabolic associated fatty liver disease in children with overweight or obesity

Pediatric Obesity, Volume 17, Issue 9, September 2022., 2022
Summary Background The early detection and management of children with metabolic associated fatty liver disease (MAFLD) is challenging. Objective To develop a non‐invasive and accurate prediction protocol for the identification of MAFLD among children with overweight/obesity candidates to confirmatory diagnosis.
Maddi Oses, Cristina Cadenas‐Sanchez, María Medrano, Arkaitz Galbete, Emiliano Miranda‐Ferrua, Jonatan R. Ruiz, Felix Sánchez‐Valverde, Francisco B. Ortega, Rafael Cabeza, Arantxa Villanueva, Fernando Idoate, Idoia Labayen   +11 more
wiley   +1 more source

Mitochondrial haplogroups have a better correlation to insulin requirement than nuclear genetic variants for type 2 diabetes mellitus in Taiwanese individuals

Journal of Diabetes Investigation, Volume 13, Issue 1, Page 201-208, January 2022., 2022
Mitochondrial haplogroups, but not nuclear genetic variants, have a better association with the insulin requirement in patients with T2DM. ABSTRACT Aims/Introduction Identifying diabetes‐susceptible genetic variants will help to provide personalized therapy for the management of type 2 diabetes. Previous studies have reported a genetic risk score (GRS),
Feng‐Chih Shen, Shao‐Wen Weng, Meng‐Han Tsai, Yu‐Jih Su, Sung‐Chou Li, Shun‐Jen Chang, Jung‐Fu Chen, Yen‐Hsiang Chang, Chia‐Wei Liou, Tsu‐Kung Lin, Jiin‐Haur Chuang, Ching‐Yi Lin, Pei‐Wen Wang   +12 more
wiley   +1 more source

Molecular Dynamics Simulation and Essential Dynamics of Deleterious Proline 12 Alanine Single‐Nucleotide Polymorphism in PPARγ2 Associated with Type 2 Diabetes, Cardiovascular Disease, and Nonalcoholic Fatty Liver Disease

PPAR Research, Volume 2022, Issue 1, 2022., 2022
Background. Peroxisome proliferator‐activated receptor‐γ (PPARγ) gene is located at 3p25 position. PPARγ functions as the master regulator of glucose homeostasis and lipoprotein metabolism, and recent studies have reported that it is involved in various metabolic diseases such as diabetes mellitus, hyperlipidemia, coronary artery disease (CAD), and ...
Somayye Taghvaei, Leila Saremi, Nguan Soon Tan   +2 more
wiley   +1 more source

Association between Genetic Polymorphisms and Risk of Kidney Posttransplant Diabetes Mellitus: A Systematic Review and Meta‐Analysis

International Journal of Clinical Practice, Volume 2022, Issue 1, 2022., 2022
Objectives. The purpose of this study was to clarify the role of genetic factors on posttransplant diabetes mellitus (PTDM) risk. Methods. Relevant publications were systematically retrieved from PubMed, EMBASE, and the Cochrane Library up to December 2020.
Shan Xu, Zhenwei Jiang, Nan Hu, Ahmed Abdelwahab   +3 more
wiley   +1 more source