Results 21 to 30 of about 1,303 (153)

ASSOCIATION ANALYSIS OF PIOGLITAZONE EFFECTIVENESS IN TREATMENT OF NAFLD PATIENTS WITH OBESITY AND PPARG RS1801282 (PRO12ALA) GENOTYPE

Wiadomości Lekarskie, 2021
The aim: To study the association between the effectiveness of treatment with pioglitazone non-alcoholic fatty liver disease (NAFLD) in patients with obesity and PPARG rs1801282 (Pro12Ala)-polymorphism in Ukrainians. Materials and methods: 123 patients with NAFLD in combination with obesity 1, 2, 3 classes were included in comprehensive weight loss ...
Vadym P, Shypulin, Oleksandr A, Martynchuk, Nikolai N, Rudenko, Aleksandr K, Koliada, Viktoriia V, Tishchenko, Nataliia H, Melnyk   +5 more
openaire   +2 more sources

Leveraging genetic ancestry to study health disparities

American Journal of Physical Anthropology, Volume 175, Issue 2, Page 363-375, June 2021., 2021
Abstract Research to understand human genomic variation and its implications in health has great potential to contribute in the reduction of health disparities. Biological anthropology can play important roles in genomics and health disparities research using a biocultural approach.
Ken Batai, Stanley Hooker, Rick A. Kittles   +2 more
wiley   +1 more source

The Effect of PPARγ rs1801282 Variant on Mortality Risk Among Asians With Chronic Kidney Disease: A Cohort Study and Meta-Analysis [PDF]

Frontiers in Genetics, 2022
Background: Chronic kidney disease (CKD) is a public health issue, and an independent risk factor for cardiovascular disease. The peroxisome proliferator-activated receptor gamma (PPARG) plays an important role in the cardiovascular system. Previous studies have examined one important exon polymorphism, Pro12Ala, in PPARG with respect to mortality of ...
Wei-Teing Chen, Wei-Teing Chen, Chih-Chien Chiu, Dung-Jang Tsai, Dung-Jang Tsai, Pi-Shao Ko, Pi-Shao Ko, Meng-Chang Lee, Hsiao-Ting Lin, Ying-Kai Chen, Ying-Kai Chen, Wen Su, Yuh-Feng Lin, Yuh-Feng Lin, Sui-Lung Su   +14 more
openaire   +3 more sources

Genetic influence of PPAR-γ rs1801282 and MTRR rs162036 variants on non-small cell lung cancer risk in Egyptians. [PDF]

Discov Oncol
Abstract Background Lung cancer remains the leading cause of cancer-related deaths worldwide. Despite advances in diagnostics and treatment, most patients are diagnosed at advanced stages. Genetic variants such as single nucleotide polymorphisms (SNPs) may improve early detection and risk ...
Metwally YF, Zahran RF, El Sadda RR, Refaat S, Elsaid AM.   +4 more
europepmc   +2 more sources

Sex and Menopause Modify the Effect of Single Nucleotide Polymorphism Genotypes on Fibrosis in NAFLD

Hepatology Communications, Volume 5, Issue 4, Page 598-607, April 2021., 2021
The development of fibrosis in nonalcoholic fatty liver disease (NAFLD) is influenced by genetics, sex, and menopausal status, but whether genetic susceptibility to fibrosis is influenced by sex and reproductive status is unclear. Our aim was to identify metabolism‐related single nucleotide polymorphisms (SNPs), whose effect on NAFLD fibrosis is ...
Kara Wegermann, Melanie E. Garrett, Jiayin Zheng, Andrea Coviello, Cynthia A. Moylan, Manal F. Abdelmalek, Shein‐Chung Chow, Cynthia D. Guy, Anna Mae Diehl, Allison Ashley‐Koch, Ayako Suzuki   +10 more
wiley   +1 more source

Genetic Predisposition to Prediabetes in the Kazakh Population. [PDF]

Curr Issues Mol Biol
The aim of this study was to conduct a comparative analysis of the population frequencies of the minor allele of polymorphic variants in the genes TCF7L2 (rs7903146) and PPARG (rs1801282), based on the genome-wide association studies analysis data ...
Svyatova G, Berezina G, Murtazaliyeva A, Dyussupov A, Belyayeva T, Faizova R, Dyussupova A.   +6 more
europepmc   +2 more sources

DataSheet_1_G Allele of the rs1801282 Polymorphism in PPARγ Gene Confers an Increased Risk of Obesity and Hypercholesterolemia, While T Allele of the rs3856806 Polymorphism Displays a Protective Role Against Dyslipidemia: A Systematic Review and Meta-Analysis.docx

, 2022
BackgroundThe relationships between the rs1801282 and rs3856806 polymorphisms in nuclear receptor peroxisome proliferator-activated receptor gamma (PPARγ) gene and obesity indexes as well as serum lipid levels have been extensively investigated in ...
Yongyan Song (4415074), Chuan He (178952), Ruixia Wang (127601), Zhifu Zeng (12970706), Qianyin Pang (12970703), Shujin Li (313783), Haiyan Nie (12970700)   +6 more
core   +1 more source

The role of the rs1801282 PPARG polymorphic marker in the prediction and choice of carbohydrate metabolism disorders management: A review

Consilium Medicum, 2022
The PPARG gene has the great value in predicting of carbohydrate metabolism disorders development and the patients response to different therapy options. The article presents the information about the association between the single nucleotide polymorphism rs1801282 PPARG and the risk of different carbohydrate metabolism disorders development based on a
Kamilya B. Khasanova, Maria S. Medvedeva, Elena V. Valeeva, Zhanna A. Rodygina, Tatiana A. Kiseleva, Farida V. Valeeva   +5 more
openaire   +2 more sources

Association between chinese medicine body constitution and variants in metabolic gene (rs1501299 & rs1801282) [PDF]

, 2022
Chinese Medicine Body Constitution (CMBC) classifies people into nine types based on physical, mental features and different disease susceptibility. Early classification of CMBC may prevent disease onset by providing prophylactic treatment, especially ...
Fong, Yu Qi
core  

DataSheet_2_G Allele of the rs1801282 Polymorphism in PPARγ Gene Confers an Increased Risk of Obesity and Hypercholesterolemia, While T Allele of the rs3856806 Polymorphism Displays a Protective Role Against Dyslipidemia: A Systematic Review and Meta-Analysis.docx

, 2022
BackgroundThe relationships between the rs1801282 and rs3856806 polymorphisms in nuclear receptor peroxisome proliferator-activated receptor gamma (PPARγ) gene and obesity indexes as well as serum lipid levels have been extensively investigated in ...
Yongyan Song (4415074), Chuan He (178952), Ruixia Wang (127601), Zhifu Zeng (12970706), Qianyin Pang (12970703), Shujin Li (313783), Haiyan Nie (12970700)   +6 more
core   +1 more source