Results 1 to 10 of about 728,144 (119)

RETRACTED ARTICLE: Targeting transforming growth factor beta (TGF-β) using Pirfenidone, a potential repurposing therapeutic strategy in colorectal cancer

Scientific Reports, 2023
The modulating factors within the tumor microenvironment, for example, transforming growth factor beta (TGF-β), may limit the response to chemo and immunotherapy protocols in colorectal cancer (CRC).
Hamid Jamialahmadi, Seyedeh Elnaz Nazari, Hamid TanzadehPanah, Ehsan Saburi, Fereshteh Asgharzadeh, Fatemeh Khojasteh-Leylakoohi, Maryam Alaei, Mahdi Mirahmadi, Fatemeh Babaei, Seyedeh Zahra Asghari, Saeide Mansouri, Ghazaleh Khalili-Tanha, Mina Maftooh, Hamid Fiuji, Seyed Mahdi Hassanian, Gordon A. Ferns, Majid Khazaei, Amir Avan   +17 more
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Machine learning algorithms reveal potential miRNAs biomarkers in gastric cancer

Scientific Reports, 2023
Gastric cancer is the high mortality rate cancers globally, and the current survival rate is 30% even with the use of combination therapies. Recently, mounting evidence indicates the potential role of miRNAs in the diagnosis and assessing the prognosis ...
Hanieh Azari, Elham Nazari, Reza Mohit, Alireza Asadnia, Mina Maftooh, Mohammadreza Nassiri, Seyed Mahdi Hassanian, Majid Ghayour-Mobarhan, Soodabeh Shahidsales, Majid Khazaei, Gordon A. Ferns, Amir Avan   +11 more
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Down regulation of Cathepsin W is associated with poor prognosis in pancreatic cancer

Scientific Reports, 2023
Pancreatic ductal adenocarcinoma (PDAC) is associated with a very poor prognosis. Therefore, there has been a focus on identifying new biomarkers for its early diagnosis and the prediction of patient survival.
Fatemeh Khojasteh-Leylakoohi, Reza Mohit, Nima Khalili-Tanha, Alireza Asadnia, Hamid Naderi, Ghazaleh Pourali, Zahra Yousefli, Ghazaleh Khalili-Tanha, Majid Khazaei, Mina Maftooh, Mohammadreza Nassiri, Seyed Mahdi Hassanian, Majid Ghayour-Mobarhan, Gordon A. Ferns, Soodabeh Shahidsales, Alfred King-yin Lam, Elisa Giovannetti, Elham Nazari, Jyotsna Batra, Amir Avan   +19 more
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Therapeutic Potential of Hydrogen-Rich Water on Muscle Atrophy Caused by Immobilization in a Mouse Model

Pharmaceuticals, 2023
Skeletal muscle atrophy is associated with poor quality of life and disability. Thus, finding a new strategy for the prevention and treatment of skeletal muscle atrophy is very crucial.
Seyedeh Elnaz Nazari, Alex Tarnava, Nima Khalili-Tanha, Mahdieh Darroudi, Ghazaleh Khalili-Tanha, Amir Avan, Majid Khazaei, Tyler W. LeBaron   +7 more
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Diagnostic Value of CK19, HBME-1 and TROP2 Biomarkers in Identification of Different Types of Thyroid Follicular Neoplasms

Acta Medica Iranica, 2021
Thyroid malignancies are found in 7% to 15% of all thyroid nodules. Immunohistochemical markers, including CK19, HBME-1and TROP2, have shown an effective role in identifying these malignancies.
Masoud Mohebbi, Shohreh Vojuhi, Zohreh Mousavi, Mohammadali Yaghoubi, Reza Ziaolhagh   +4 more
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Bioinformatics analysis and machine learning approach applied to the identification of novel key genes involved in non-alcoholic fatty liver disease

Scientific Reports, 2023
Non-alcoholic fatty liver disease (NAFLD) comprises a range of chronic liver diseases that result from the accumulation of excess triglycerides in the liver, and which, in its early phases, is categorized NAFLD, or hepato-steatosis with pure fatty liver.
Elham Nazari, Ghazaleh Khalili-Tanha, Alireza Asadnia, Ghazaleh Pourali, Mina Maftooh, Majid Khazaei, Mohammadreza Nasiri, Seyed Mahdi Hassanian, Majid Ghayour-Mobarhan, Gordon A. Ferns, Mohammad Ali Kiani, Amir Avan   +11 more
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DsbA-L deficiency in T cells promotes diet-induced thermogenesis through suppressing IFN-γ production

Nature Communications, 2021
Adipose tissue-resident T cells are known to regulate thermogenesis and energy expenditure. Here the authors report that deletion of mitochondria-localized protein DsbA-L in T cells promotes diet-induced thermogenesis via suppressing IFN-γ production.
Haiyan Zhou, Xinyi Peng, Jie Hu, Liwen Wang, Hairong Luo, Junyan Zhang, Yacheng Zhang, Guobao Li, Yujiao Ji, Jingjing Zhang, Juli Bai, Meilian Liu, Zhiguang Zhou, Feng Liu   +13 more
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Chemical analysis of atherosclerotic plaque cholesterol combined with histology of the same tissue

Journal of Lipid Research, 2008
Sensitive method for chemical analysis of free cholesterol (FC) and cholesterol esters (CE) was developed. Mouse arteries were dissected and placed in chloroform-methanol without tissue grinding.
Ming-Shang Kuo, J. Michael Kalbfleisch, Pamela Rutherford, Donetta Gifford-Moore, Xiao-di Huang, Robert Christie, Kwan Hui, Kenneth Gould, Mark Rekhter   +8 more
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Circulating Markers Reflect Both Anti- and Pro-Atherogenic Drug Effects in ApoE-Deficient Mice

Biomarker Insights, 2008
Background Current drug therapy of atherosclerosis is focused on treatment of major risk factors, e.g. hypercholesterolemia while in the future direct disease modification might provide additional benefits.
Birong Liao, Eileen McCall, Karen Cox, Chung-Wein Lee, Shuguang Huang, Richard E Higgs, Li-Chun Chio, Eugene Zhen, John E Hale, Nancy K Jackson, Pamela G Rutherford, Xiao-di Huang, Donetta Gifford-Moore, Kwan Hui, Kevin Duffin, Kenneth E Gould, Mark Rekhter   +16 more
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Oral Administration of Achyranthis radix Extract Prevents TMA-induced Allergic Contact Dermatitis by Regulating Th2 Cytokine and Chemokine Production in Vivo

Molecules, 2015
Allergic contact dermatitis (ACD) remains a major skin disease in many countries, necessitating the discovery of novel and effective anti-ACD agents. In this study, we investigated the preventive effects of Achyranthis radix extract (AcRE) on trimellitic
Sung Keun Jung, Dae Woon Choi, Da-Ae Kwon, Min Jung Kim, Ki Seung Seong, Dong-Hwa Shon   +5 more
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