(E)-3-(4-(tert-Butyl)Phenyl)-N-Isobutyl-2-Methylacrylamide Suppresses Adipogenesis in High-Fat-Fed Mice [PDF]
Acta Poloniae Pharmaceutica, 2023 Obesity is caused by excessive adipogenesis and leads to metabolic diseases such as diabetes, hypertension, and degenerative arthritis. Therefore, there is an ever-increasing need to identify new anti-obesity compounds.
Jinyoung Hur +6 more
doaj +1 more source
L-carnitine administration effects on AMPK, APPL1 and PPARγ genes expression in the liver and serum adiponectin levels and HOMA-IR in type 2 diabetes rat model induced by STZ and nicotinamide [PDF]
The Ukrainian Biochemical Journal, 2020 Diabetes is a chronic disease and a public health problem globally. L-Carnitine is synthesized in the liver, promotes fatty acids oxidation and currently is used as a supplement against weight gain.
B. Shahouzehi +2 more
doaj +1 more source
Evaluation of the Effect of Co-administration of IRAK Inhibitor and Pioglitazone on PPAR-γ, GLUT-4, TNF-α, and Leptin Genes Expression in Adipose Tissue of Insulin-resistant Mice [PDF]
Journal of Kerman University of Medical Sciences, 2021 Background: The worldwide prevalence of diabetes is increasing. Diabetes is a complex disease that results from impaired secretion of insulin or insulin resistance.
Saeedeh Moinaldini +3 more
doaj +1 more source
The effect of eight-week resistance training and consumption of grape seed nanoparticles on mitochondrial biogenesis of heart tissue in the myocardial infarction model [PDF]
Journal of Shahrekord University of Medical Sciences, 2022 Background and aims: The consumption of grape seed nanoparticles extract can control cardiovascular risk factors. Exercise plays a protective role against cardiovascular disease.
Ebrahim Khaki +3 more
doaj +1 more source
Cancer Biology & Medicine, 2023 Objective: Polyploid giant cancer cells (PGCCs) with daughter cells express epithelial–mesenchymal transition (EMT)-associated proteins. Highly malignant tumor cells with EMT properties can transdifferentiate into mature tumor cells.
Kexin Zhang +4 more
doaj +1 more source
Shockwaves Suppress Adipocyte Differentiation via Decrease in PPARγ
Cells, 2020 Adipogenesis is a crucial cellular process that contributes to the expansion of adipose tissue in obesity. Shockwaves are mechanical stimuli that transmit signals to cause biological responses.
Wonkyoung Cho +3 more
doaj +1 more source
PPARγ: the dominant regulator among PPARs in dry eye lacrimal gland and diabetic lacrimal gland [PDF]
International Journal of Ophthalmology, 2020 AIM: To investigate the regulatory roles of the members of the peroxisome proliferator-activated receptor (PPAR) family in lacrimal gland dysfunction under conditions of desiccating stress or diabetes.
Peng-Yue Mu +4 more
doaj +1 more source
Astragaloside IV regulates autophagy-mediated proliferation and apoptosis in a rat model of PCOS by activating the PPARγ pathway [PDF]
Iranian Journal of Basic Medical Sciences, 2022 Objective(s): Astragaloside IV (AS-IV) is a bioactive saponin with a wide range of pharmacological effects. This study was aimed at investigating its potential effect on polycystic ovary syndrome (PCOS).
Mingxiao Wen +3 more
doaj +1 more source
Curcumin improves adipocytes browning and mitochondrial function in 3T3-L1 cells and obese rodent model [PDF]
Royal Society Open Science, 2021 Accumulating evidence suggests that mitochondrial dysfunction and adipocyte differentiation promote lipid accumulation in the development of obesity and diabetes.
Dandan Zhao +12 more
doaj +1 more source
Exercise retards ongoing adipose tissue fibrosis in diet-induced obese mice
Endocrine Connections, 2021 Exercise has been recommended as an important strategy to impro ve glucose metabolism in obesity. Adipose tissue fibrosis is associated with inflammati on and is implicated in glucose metabolism disturbance and insulin resistance in obesit y.
Liangming Li +10 more
doaj +1 more source