Results 1 to 10 of about 66,281 (214)

Serum 15-d-PGJ2 and PPARγ levels are reduced in manic episode of bipolar disorder while IL-4 levels are not affected

Psychiatry and Clinical Psychopharmacology, 2019
OBJECTIVES: Bipolar disorder (BD) carries a high rate of morbidity and mortality, and the clarification of its aetiology continues to be an important field of research.
Gamze Erzin, Makbule Çiğdem Aydemir, Rabia Nazik Yüksel, Elif Tatlıdil Yaylacı, Bağdagül Çakır, Sevilay Sezer, Erol Göka   +6 more
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Inclisiran inhibits oxidized low-density lipoprotein-induced foam cell formation in Raw264.7 macrophages via activating the PPARγ pathway

Autoimmunity, 2022
Proprotein convertase subtilisin kexin type 9 (PCSK9) is a well-known proprotein convertase that influences foam cell formation and modulates atherosclerosis. Inclisiran is a novel chemosynthetic small interfering RNA that inhibits PCSK9 synthesis.
Zhaoping Wang, Xiangyu Chen, Jingxing Liu, Yingcui Wang, Suhua Zhang   +4 more
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CircRNF111 Contributes to Adipocyte Differentiation by Elevating PPARγ Expression via miR-27a-3p

Epigenetics, 2023
The content and distribution of adipocytes is an important factor that affects meat quality. Previous studies showed that circRNAs are involved in various physiological processes.
Xuemei Shen, Jia Tang, Yongzhen Huang, Xianyong Lan, Chuzhao Lei, Hong Chen   +5 more
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Effects of Aerobic Interval Training and Adenosine on the Expression of AMPK, PPARγ and A2B Receptor in the Liver of Rats Fed a High-Fat Diet [PDF]

Journal of Advanced Biomedical Sciences, 2020
Background & Objective: Obesity causes steatosis in the liver. PPARγ transcription factor of glucose and fat metabolism genes and AMPK cell energy sensor are considered as therapeutic targets in non-alcoholic fatty liver (NAFLD) patients.
Abolhasan Hedayati katooli, Mohammad Ali Azarbayjani, Abdolali Banaeifar, Sajad Arshadi   +3 more
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The Role of PPARγ Gene Polymorphisms, Gut Microbiota in Type 2 Diabetes: Current Progress and Future Prospects

Diabetes, Metabolic Syndrome and Obesity, 2023
Yi-Kun Zhao,1 Xiang-Dong Zhu,2 Rong Liu,1 Xia Yang,1 Yong-Lin Liang,1 Yan Wang2 1Department of Basic Medical College, Gansu University of Chinese Medicine, Lanzhou City, People’s Republic of China; 2Department of Traditional Chinese Medicine College ...
Zhao YK, Zhu XD, Liu R, Yang X, Liang YL, Wang Y   +5 more
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Enhanced anticancer effect of cetuximab combined with ethanol extract of Volvariella volvacea in colorectal cancer targeted TOP2A and PPARγ [PDF]

Journal of Pharmacy & Pharmacognosy Research
Context: Colorectal cancer (CRC) is a major global health concern as innovative therapeutic strategies to enhance treatment outcomes. This study investigates the therapeutic potential of the ethanol extract derived from Volvariella volvacea in ...
Sofy Permana, Elsafira A. Nabilahasna, Fairuz A. Meilany, Silvi Zakiyatul Ilmiyah, Edwin Widodo, Eviana Norahmawati, Yoshiyuki Kawamoto, Heni Endrawati, Agustina T. Endharti   +8 more
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VSP-2 attenuates secretion of inflammatory cytokines induced by LPS in BV2 cells by mediating the PPARγ/NF-κB signaling pathway

Open Life Sciences
Neuroinflammation, characterized by microglial activation and the subsequent secretion of inflammatory cytokines, plays a pivotal role in neurodegenerative diseases and brain injuries, often leading to neuronal damage and death.
Cui Jingxin, Xu Liwei, Sun Yimeng, Dai Lingfei, Mo Yuxiu, Yun Keli, Chen Yifei, Chen Linglin   +7 more
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Synthesis and Biological Activity of Piperine Derivatives as Potential PPARγ Agonists

Drug Design, Development and Therapy, 2020
Yanli Wang,1– 3 Yuan Yao,4,5 Jing Liu,2,6 Lili Wu,7 Tonghua Liu,7 Jian Cui,1 David Yue-Wei Lee2 1School of Pharmacy, Minzu University of China, Beijing 100081, People’s Republic of China; 2Bio-Organic and Natural Products Laboratory, McLean ...
Wang Y, Yao Y, Liu J, Wu L, Liu T, Cui J, Lee DYW   +6 more
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Cynarin inhibits PDGF-BB-induced proliferation and activation in hepatic stellate cells through PPARγ

Open Chemistry, 2022
Cynarin, a caffeoylquinic acid compound that was mainly extracted from Cynara scolymus L., displays various activities such as antioxidant, antibacterial, choleretic, and hepatoprotective functions. However, the target of cynarin and the mechanism of its
Ding Yong, Tao Congcong, Chen Qian, Chen Lulu, Hu Xianwen, Li Mingyu, Wang Shicong, Jiang Fuquan   +7 more
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Identification and Isolation of Active Compounds from Astragalus membranaceus that Improve Insulin Secretion by Regulating Pancreatic Β-Cell Metabolism

Biomolecules, 2019
In type 2 diabetes (T2D), insufficient secretion of insulin from the pancreatic β-cells contributes to high blood glucose levels, associated with metabolic dysregulation.
Dahae Lee, Da Hye Lee, Sungyoul Choi, Jin Su Lee, Dae Sik Jang, Ki Sung Kang   +5 more
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