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Pivotal contribution of super-enhancer-driven KLF6 expression to the adipogenesis of human adipose-derived stem cells [PDF]

Inflammation and Regeneration
Background Super-enhancers (SEs), characterized by dense clusters of enhancer elements enriched with transcriptional activator binding sites, are involved in cell differentiation. However, little is known about SE-mediated regulation of adipogenic genes.
Mai-Phuong Nguyen, Kaoru Yamagata, Anh Phuong Nguyen, Tong Zhang, Hidenori Sakai, Uyen Thi Ngo, Yu Shan, Takashi Otsuka, Ngo Thi Dieu Huong, Takafumi Aritomi, Meng Yuan, Shigeaki Kato, Yoshiya Tanaka, Shingo Nakayamada   +13 more
doaj   +2 more sources

Ocimum basilicum L. Methanol Extract Enhances Mitochondrial Efficiency and Decreases Adipokine Levels in Maturing Adipocytes Which Regulate Macrophage Systemic Inflammation

Molecules, 2022
Excessive storage of lipids in visceral or ectopic sites stimulates adipokine production, which attracts macrophages. This process determines the pro- and anti-inflammatory response regulation in adipose tissue during obesity-associated systemic ...
Pandurangan Subash-Babu, Hussah Mohammed Alowaidh, Laila Naif Al-Harbi, Ghalia Shamlan, Amal A. Aloud, Sahar Abdulaziz AlSedairy, Ali Abdullah Alshatwi   +6 more
doaj   +1 more source

Luteolin-7-O-rutinoside Protects RIN-5F Cells from High-Glucose-Induced Toxicity, Improves Glucose Homeostasis in L6 Myotubes, and Prevents Onset of Type 2 Diabetes

Metabolites, 2023
Luteolin-7-O-rutinoside (lut-7-O-rutin), a flavonoid commonly present in Mentha longifolia L. and Olea europaea L. leaves has been used as a flavoring agent with some biological activity.
Pandurangan Subash-Babu, Sahar Abdulaziz AlSedairy, Manal Abdulaziz Binobead, Ali A. Alshatwi   +3 more
doaj   +1 more source

Prevalence of using herbs and natural products as a protective measure during the COVID-19 pandemic among the Saudi population: an online cross-sectional survey

Saudi Pharmaceutical Journal, 2021
Considering that no food or supplement has been authorised to prevent COVID-19, individuals continue to search for and consume specific herbs, foods and commercial supplements for this purpose.
Amna Abdullah Alotiby, Laila Naif Al-Harbi   +1 more
doaj   +1 more source

A chromatin accessibility landscape during early adipogenesis of human adipose-derived stem cells

Adipocyte, 2022
Obesity has become a serious global public health problem; a deeper understanding of systemic change of chromatin accessibility during human adipogenesis contributes to conquering obesity and its related diseases.
Sen Li, Xiaolin Zong, Liheng Zhang, Luya Li, Jianxin Wu   +4 more
doaj   +1 more source

Adipogenesis in triple-negative breast cancer is associated with unfavorable tumor immune microenvironment and with worse survival

Scientific Reports, 2021
Cancer-associated adipocytes are known to cause inflammation; however, the role of adipogenesis, the formation of adipocytes, in breast cancer is unclear.
Masanori Oshi, Yoshihisa Tokumaru, Fernando A. Angarita, Lan Lee, Li Yan, Ryusei Matsuyama, Itaru Endo, Kazuaki Takabe   +7 more
doaj   +1 more source

Beneficial Fatty Acid Ratio of Salvia hispanica L. (Chia Seed) Potentially Inhibits Adipocyte Hypertrophy, and Decreases Adipokines Expression and Inflammation in Macrophage

Foods, 2020
The present study aimed to determine the role of Salvia hispanica L., (chia seed) fatty acid content in adipocyte lipid accumulation and human macrophage immunoregulatory potential.
Subash-Babu Pandurangan, Salah A. Al-Maiman, Laila Naif Al-Harbi, Ali A. Alshatwi   +3 more
doaj   +1 more source

METTL3 mediates bone marrow mesenchymal stem cell adipogenesis to promote chemoresistance in acute myeloid leukaemia

FEBS Open Bio, 2021
Adipogenesis of bone marrow mesenchymal stem cells (MSCs) promotes chemoresistance of acute myeloid leukaemia (AML) cells. MSCs from AML patients (AML‐MSCs) display enhanced adipogenesis compared with bone marrow MSCs from healthy donors.
Zhi‐peng Pan, Bin Wang, Di‐yu Hou, Ruo‐lan You, Xiao‐ting Wang, Wen‐hui Xie, Hui‐fang Huang   +6 more
doaj   +1 more source

RNA-seq analysis reveals the critical role of the novel lncRNA BIANCR in intramuscular adipogenesis through the ERK1/2 signaling pathway

Journal of Animal Science and Biotechnology, 2023
Background Long non-coding RNAs (lncRNAs) regulate numerous biological processes, including adipogenesis. Research on adipogenesis will assist in the treatment of human metabolic diseases and improve meat quality in livestock, such as the content of ...
Xinhao Ma, Xinran Yang, Dianqi Zhang, Wenzhen Zhang, Xiaoyu Wang, Kuncheng Xie, Jie He, Chugang Mei, Linsen Zan   +8 more
doaj   +1 more source

Regulatory network of metformin on adipogenesis determined by combining high-throughput sequencing and GEO database

Adipocyte, 2022
Adipose differentiation and excessive lipid accumulation are the important characteristics of obesity. Metformin, as a classic hypoglycaemic drug, has been proved to reduce body weight in type 2 diabetes, the specific mechanism has not been completely ...
Zhicong Zhao, Chenxi Wang, Jue Jia, Zhaoxiang Wang, Lian Li, Xia Deng, Zhensheng Cai, Ling Yang, Dong Wang, Suxian Ma, Li Zhao, Zhigang Tu, Guoyue Yuan   +12 more
doaj   +1 more source