Results 1 to 10 of about 94,652 (323)

RNA-seq analysis reveals the critical role of the novel lncRNA BIANCR in intramuscular adipogenesis through the ERK1/2 signaling pathway

Journal of Animal Science and Biotechnology, 2023
Background Long non-coding RNAs (lncRNAs) regulate numerous biological processes, including adipogenesis. Research on adipogenesis will assist in the treatment of human metabolic diseases and improve meat quality in livestock, such as the content of ...
Xinhao Ma, Xinran Yang, Dianqi Zhang, Wenzhen Zhang, Xiaoyu Wang, Kuncheng Xie, Jie He, Chugang Mei, Linsen Zan   +8 more
doaj   +2 more sources

m6A mRNA methylation controls autophagy and adipogenesis by targeting Atg5 and Atg7

Autophagy, 2020
N 6-methyladenosine (m6A), the most abundant internal modification on mRNAs in eukaryotes, play roles in adipogenesis. However, the underlying mechanism remains largely unclear.
Hailing Shi, Zhi Li, Fengqin Wang
exaly   +2 more sources

Adipogenesis in triple-negative breast cancer is associated with unfavorable tumor immune microenvironment and with worse survival

Scientific Reports, 2021
Cancer-associated adipocytes are known to cause inflammation; however, the role of adipogenesis, the formation of adipocytes, in breast cancer is unclear.
Masanori Oshi, Yoshihisa Tokumaru, Fernando A. Angarita, Lan Lee, Li Yan, Ryusei Matsuyama, Itaru Endo, Kazuaki Takabe   +7 more
doaj   +2 more sources

METTL3 mediates bone marrow mesenchymal stem cell adipogenesis to promote chemoresistance in acute myeloid leukaemia

FEBS Open Bio, 2021
Adipogenesis of bone marrow mesenchymal stem cells (MSCs) promotes chemoresistance of acute myeloid leukaemia (AML) cells. MSCs from AML patients (AML‐MSCs) display enhanced adipogenesis compared with bone marrow MSCs from healthy donors.
Zhi‐peng Pan, Bin Wang, Di‐yu Hou, Ruo‐lan You, Xiao‐ting Wang, Wen‐hui Xie, Hui‐fang Huang   +6 more
doaj   +2 more sources

Transcriptional and post-transcriptional control of autophagy and adipogenesis by YBX1

Cell Death and Disease, 2023
Obesity is strongly associated with metabolic diseases, which have become a global health problem. Exploring the underlying mechanism of adipogenesis is crucial for the treatment of excess white fat.
Ruifan Wu, Shengchun Feng, Fan Li, Gang Shu, Lina Wang, Ping Gao, Xiaotong Zhu, Canjun Zhu, Songbo Wang, Qingyan Jiang   +9 more
doaj   +2 more sources

Omega-3 Fatty Acids Activate Ciliary FFAR4 to Control Adipogenesis

Cell, 2019
Summary Adult mesenchymal stem cells, including preadipocytes, possess a cellular sensory organelle called the primary cilium. Ciliated preadipocytes abundantly populate perivascular compartments in fat and are activated by high fat diet. Here, we sought
Daniel Kopinke, Keren I Hilgendorf, Peter K Jackson   +2 more
exaly   +2 more sources

Transcriptional and Epigenomic Regulation of Adipogenesis

Molecular and Cellular Biology, 2019
Understanding adipogenesis, the process of adipocyte development, may provide new ways to treat obesity and related metabolic diseases. Adipogenesis is controlled by coordinated actions of lineage-determining transcription factors and epigenomic ...
Binbin Lai, Ji-Eun Lee, Kai Ge
exaly   +2 more sources

Adipogenesis: A Complex Interplay of Multiple Molecular Determinants and Pathways

International Journal of Molecular Sciences, 2020
The formation of adipocytes during embryogenesis has been largely understudied. However, preadipocytes appear to originate from multipotent mesenchymal stromal/stem cells which migrate from the mesoderm to their anatomical localization.
Michael S Pepper, Priyanka Dhanraj, Melvin Ambele   +2 more
exaly   +2 more sources

Novel insights into regulators and functional modulators of adipogenesis

Biomedicine and Pharmacotherapy
Adipogenesis is a process that differentiates new adipocytes from precursor cells and is tightly regulated by several factors, including many transcription factors and various post-translational modifications.
Jun Hong Park, Hyun-Jun Jang, Younghoon Go   +2 more
exaly   +2 more sources

TMBIM1 is an inhibitor of adipogenesis and its depletion promotes adipocyte hyperplasia and improves obesity-related metabolic disease

Cell Metabolism, 2021
Obesity is characterized by the excessive accumulation of the white adipose tissue (WAT), but healthy expansion of WAT via adipocyte hyperplasia can offset the negative metabolic effects of obesity.
Man-Li Hu, Zhi-Gang She, Tian Tian
exaly   +2 more sources