Results 41 to 50 of about 69,441 (277)

Transcriptional and post-transcriptional control of autophagy and adipogenesis by YBX1

Cell Death and Disease, 2023
Obesity is strongly associated with metabolic diseases, which have become a global health problem. Exploring the underlying mechanism of adipogenesis is crucial for the treatment of excess white fat.
Ruifan Wu, Shengchun Feng, Fan Li, Gang Shu, Lina Wang, Ping Gao, Xiaotong Zhu, Canjun Zhu, Songbo Wang, Qingyan Jiang   +9 more
doaj   +1 more source

The Marine Factor 3,5-Dihydroxy-4-methoxybenzyl Alcohol Represses Adipogenesis in Mouse 3T3-L1 Adipocytes In Vitro: Regulating Diverse Signaling Pathways

Nutraceuticals, 2023
The augmentation of adipocytes in the adipose tissues brings disordered pathophysiological conditions, including type 2 diabetes, hyperlipidemia, hypertension, cardiovascular disease, and cancer.
Masayoshi Yamaguchi, Kenji Yoshiike, Hideaki Watanabe, Mitsugu Watanabe   +3 more
doaj   +1 more source

A Spatiotemporal Proteomic Map of Human Adipogenesis

, 2023
SUMMARY White adipocytes function as the major energy reservoir in humans by storing substantial amounts of triglycerides and their dysfunction is associated with metabolic disorders.
Iuso, A, Klingelhuber, F, Omar-Hmeadi, M, Wabitsch, M, Messias, A, Frendo-Cumbo, S, Kakimoto, P, Taylor, A, Ribicic, S, Couchet, M   +9 more
core   +1 more source

Long noncoding RNAs regulate adipogenesis

, 2012
The prevalence of obesity has led to a surge of interest in understanding the detailed mechanisms underlying adipocyte development. Many protein-coding genes, mRNAs, and microRNAs have been implicated in adipocyte development, but the global expression ...
Hacisuleyman, Ezgi, Sauvageau, Martin, Yuan, Bingbing B., Hendrickson, David G., Kellis, Manolis, Kelley, David R., Tazon-Vega, Barbara, Goff, Loyal, Rinn, John L., Alexander, Ryan K., Sun, Lei, Lo, Kinyui Alice, Lodish, Harvey F., Trapnell, Cole   +13 more
core   +2 more sources

The Phytochemical Rhein Mediates M6A-Independent Suppression of Adipocyte Differentiation

Frontiers in Nutrition, 2021
Adipogenesis is mediated by the complex gene expression networks involving the posttranscriptional modifications. The natural compound rhein has been linked to the regulation of adipogenesis, but the underlying regulatory mechanisms remain elusive ...
Linyuan Huang, Jun Zhang, Xinyun Zhu, Xue Mi, Qiujie Li, Jing Gao, Jianheng Zhou, Jun Zhou, Jun Zhou, Xiao-Min Liu   +9 more
doaj   +1 more source

Transcriptional regulation of adipogenesis [PDF]

Genes & Development, 2000
Version of ...
Rosen, Evan D., Walkey, Christopher J., Puigserver, Pere, Spiegelman, Bruce M.   +3 more
openaire   +4 more sources

Inhibition of inosine monophosphate dehydrogenase reduces adipogenesis and diet-induced obesity

, 2009
We previously described a putative role for inosine monophosphate dehydrogenase (IMPDH), a rate-limiting enzyme in de novo guanine nucleotide biosynthesis, in lipid accumulation.
Hutley, Louise J., Whitehead, Jonathan P., Connor, Tim, Segal, David, Prins, Johannes B., Walder, Ken, Molero, Juan Carlos, Wanyonyi, Stephen, Reizes, Ofer, de Vries, Melissa, Newell, Felicity S., Su, Hua, Gunter, Jennifer H.   +12 more
core   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Zymosan-induced inflammation stimulates neo-adipogenesis

, 2008
Objective: To investigate the potential of inflammation to induce new adipose tissue formation in the in vivo environment.\ud \ud Methods and results: Using an established model of in vivo adipogenesis, a silicone chamber containing a Matrigel and ...
G P L Thomas, A J Penington, Thompson, Erik W., W A Morrison, McCombe, D., Penington, A. J., Abberton, K. M., Hemmrich, Karsten, Thompson, E. W., Thomas, G. P. L., Morrison, W. A., D McCombe, Abberton, Keren M., K M Abberton, Hemmrich, K., E W Thompson, K Hemmrich   +16 more
core   +1 more source

Gene-chip studies of adipogenesis-regulated microRNAs in mouse primary adipocytes and human obesity

BMC Endocrine Disorders, 2011
Background Adipose tissue abundance relies partly on the factors that regulate adipogenesis, i.e. proliferation and differentiation of adipocytes. While components of the transcriptional program that initiates adipogenesis is well-known, the importance ...
Gallagher Iain J, Petrovic Natasa, Gburcik Valentina, Keller Pernille, Nedergaard Jan, Cannon Barbara, Timmons James A   +6 more
doaj   +1 more source