Adipogenesis at a glance [PDF]
Journal of Cell Science, 2011 The formation of adipocytes from precursor stem cells involves a complex and highly orchestrated programme of gene expression. Our understanding of the basic network of transcription factors that regulates adipogenesis has remained remarkably unchanged in recent years.
Christopher E, Lowe +2 more
openaire +3 more sources
Adipocyte, 2022 Adipose differentiation and excessive lipid accumulation are the important characteristics of obesity. Metformin, as a classic hypoglycaemic drug, has been proved to reduce body weight in type 2 diabetes, the specific mechanism has not been completely ...
Zhicong Zhao +12 more
doaj +1 more source
Running Against the Wnt: How Wnt/β-Catenin Suppresses Adipogenesis
Frontiers in Cell and Developmental Biology, 2021 Mesenchymal stem cells (MSCs) give rise to adipocytes, osteocytes, and chondrocytes and reside in various tissues, including bone marrow and adipose tissue.
Twan J. J. de Winter, R. Nusse
semanticscholar +1 more source
Identification of a regulatory pathway inhibiting adipogenesis via RSPO2
Nature Metabolism, 2022 Healthy adipose tissue remodeling depends on the balance between de novo adipogenesis from adipogenic progenitor cells and the hypertrophy of adipocytes.
H. Dong +12 more
semanticscholar +1 more source
Matrix Stiffness Orchestrates Mesenchymal Stem Cell Lineage Commitment Toward Osteogenesis and Adipogenesis Through the PIEZO1/SP1/STC2 Axis. [PDF]
Adv Sci (Weinh)Matrix stiffness directs mesenchymal stem cell lineage commitment through PIEZO1‐dependent activation of the SP1/STC2 pathway. Stiff matrices favor osteogenesis and suppress adipogenesis, whereas the loss of PIEZO1 function impairs early bone formation. STC2 retains lineage‐regulatory activity even when PIEZO1 is inactive.
Zhang S +12 more
europepmc +2 more sources
Adipocyte differentiation between obese and lean conditions depends on changes in miRNA expression
Scientific Reports, 2022 Adipogenesis is the process by which precursor cells, preadipocytes (preACs), differentiate into adipocytes (ACs). Here, we investigated differentially expressed miRNAs (DEMs) between the two conditions to understand the regulatory role of miRNAs in ...
Yerim Heo +3 more
doaj +1 more source
Molecular Regulation of Lipogenesis, Adipogenesis and Fat Deposition in Chicken
Genes, 2021 In the poultry industry, excessive fat deposition is considered an undesirable factor, affecting feed efficiency, meat production cost, meat quality, and consumer’s health.
Sara Nematbakhsh +5 more
semanticscholar +1 more source
Bisecting GlcNAc Protein N-Glycosylation Is Characteristic of Human Adipogenesis
, 2021 Human adipose tissue contains a major source of adipose-derived stem cells (ADSCs) that have the ability to differentiate into various cell types: in vitro, ADSCs can differentiate into mesenchymal lineages including adipocytes, while in vivo, ADSCs ...
Wongtrakul-Kish, Katherine +2 more
core +1 more source
Reverse differentiation as a gene filtering tool in genome expression profiling of adipogenesis for fat marker gene selection and their analysis. [PDF]
PLoS ONE, 2013 BACKGROUND: During mesenchymal stem cell (MSC) conversion into adipocytes, the adipogenic cocktail consisting of insulin, dexamethasone, indomethacin and 3-isobutyl-1-methylxanthine not only induces adipogenic-specific but also genes for non-adipogenic ...
Mujib Ullah +5 more
doaj +1 more source
Exosomes Derived From M2 Macrophages Facilitate Osteogenesis and Reduce Adipogenesis of BMSCs
Frontiers in Endocrinology, 2021 Bone regeneration is a complex process that requires the coordination of osteogenesis and osteoclastogenesis. The balance between osteogenesis and adipogenesis of bone marrow mesenchymal stem cells (BMSCs) plays a major role in the process of bone ...
Ziyi Li +3 more
semanticscholar +1 more source