Thermogenic Ability of Uncoupling Protein 1 in Beige Adipocytes in Mice [PDF]
PLoS ONE, 2013 Chronic adrenergic activation leads to the emergence of beige adipocytes in some depots of white adipose tissue in mice. Despite their morphological similarities to brown adipocytes and their expression of uncoupling protein 1 (UCP1), a thermogenic ...
Yuko Okamatsu-Ogura +2 more
exaly +2 more sources
Transferrin Receptor Functionally Marks Thermogenic Adipocytes
Frontiers in Cell and Developmental Biology, 2020 BackgroundThermogenic adipocytes, including beige and brown adipocytes, are critical for thermogenesis and energy homeostasis. Identification of functional cell surface markers of thermogenic adipocytes is of significance for potential application in ...
Xuejiang Gu, Jiqiu Wang, Tianhui Hu
exaly +3 more sources
Asc-1 regulates white versus beige adipocyte fate in a subcutaneous stromal cell population
Nature Communications, 2021 Adipose tissue is composed of a variety of cell types, including adipocyte precursor populations, that contribute to adipose tissue function upon differentiation. Here, using scRNA-sequencing of adolescent and adult mouse subcutaneous adipose tissue, the
Lisa Suwandhi +20 more
doaj +1 more source
Reduced intestinal lipid absorption improves glucose metabolism in aged G2-Terc knockout mice
BMC Biology, 2023 Background Biological aging is an important factor leading to the development of pathologies associated with metabolic dysregulation, including type 2 diabetes, cancer, cardiovascular and neurodegenerative diseases.
Xue Liu +10 more
doaj +1 more source
Immune Cell Regulation of White Adipose Progenitor Cell Fate
Frontiers in Endocrinology, 2022 Adipose tissue is essential for energy storage and endocrine regulation of metabolism. Imbalance in energy intake and expenditure result in obesity causing adipose tissue dysfunction.
Irem Altun +6 more
doaj +1 more source
PAT2 regulates vATPase assembly and lysosomal acidification in brown adipocytes
Molecular Metabolism, 2022 Objective: Brown adipocytes play a key role in maintaining body temperature as well as glucose and lipid homeostasis. However, brown adipocytes need to adapt their thermogenic activity and substrate utilization to changes in nutrient availability ...
Jiefu Wang +9 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2022 Abdominal obesity associates with cardiometabolic disease and an accumulation of lipids in the visceral adipose depot, whereas lipid accumulation in the subcutaneous depot is more benign.
Neha Mathur +12 more
doaj +1 more source
Active integrins regulate white adipose tissue insulin sensitivity and brown fat thermogenesis
Molecular Metabolism, 2021 Objective: Reorganization of the extracellular matrix is a prerequisite for healthy adipose tissue expansion, whereas fibrosis is a key feature of adipose dysfunction and inflammation.
Francisco Javier Ruiz-Ojeda +15 more
doaj +1 more source
Integrin αV Mediates the Effects of Irisin on Human Mature Adipocytes
Obesity Facts, 2022 Introdution and Aims: The myokine irisin is critical to modulating adipocytes thermogenesis and influence whole-body metabolism. However, whether there is difference in the effects of irisin on adipocytes derived from different depots remains unknown ...
Tingting Fu +6 more
doaj +1 more source
AMP-Activated Kinase (AMPK) Activation by AICAR in Human White Adipocytes Derived from Pericardial White Adipose Tissue Stem Cells Induces a Partial Beige-Like Phenotype. [PDF]
PLoS ONE, 2016 Beige adipocytes are special cells situated in the white adipose tissue. Beige adipocytes, lacking thermogenic cues, morphologically look quite similar to regular white adipocytes, but with a markedly different response to adrenalin.
Omar Abdul-Rahman +18 more
doaj +1 more source