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Bone marrow adipocytes [PDF]

Adipocyte, 2017
Adipocytes were identified in human bone marrow more than a century ago, yet until recently little has been known about their origin, development, function or interactions with other cells in the bone marrow.
M. Horowitz, Ryan Berry, Brandon Holtrup, Zachary L. Sebo, T. Nelson, Jackie A Fretz, D. Lindskog, Jennifer L. Kaplan, G. Ables, Matthew S. Rodeheffer, C. Rosen   +10 more
semanticscholar   +4 more sources

Chronic Peroxisome Proliferator-activated Receptor γ (PPARγ) Activation of Epididymally Derived White Adipocyte Cultures Reveals a Population of Thermogenically Competent, UCP1-containing Adipocytes Molecularly Distinct from Classic Brown Adipocytes*

Journal of Biological Chemistry, 2009
The recent insight that brown adipocytes and muscle cells share a common origin and in this respect are distinct from white adipocytes has spurred questions concerning the origin and molecular characteristics of the UCP1-expressing cells observed in ...
N. Petrovic, Tomas B. Waldén, I. Shabalina, J. Timmons, B. Cannon, J. Nedergaard   +5 more
semanticscholar   +1 more source

Intermittent fasting promotes type 3 innate lymphoid cells secreting IL-22 contributing to the beigeing of white adipose tissue

eLife
Mechanism underlying the metabolic benefit of intermittent fasting remains largely unknown. Here, we reported that intermittent fasting promoted interleukin-22 (IL-22) production by type 3 innate lymphoid cells (ILC3s) and subsequent beigeing of ...
Hong Chen, Lijun Sun, Lu Feng, Xue Han, Yunhua Zhang, Wenbo Zhai, Zehe Zhang, Michael Mulholland, Weizhen Zhang, Yue Yin   +9 more
doaj   +1 more source

Reversible De-differentiation of Mature White Adipocytes into Preadipocyte-like Precursors During Lactation

Cell Metabolism, 2018
SUMMARY Adipose tissue in the mammary gland undergoes dramatic remodeling during reproduction. Adipocytes are replaced by mammary alveolar structures during pregnancy and lactation, then reappear upon weaning.
Qiong A. Wang, Anying Song, Wanze Chen, Petra C. Schwalie, Fang Zhang, Lavanya Vishvanath, Lei Jiang, Risheng Ye, Mengle Shao, Caroline Tao, Rana K. Gupta, B. Deplancke, P. Scherer   +12 more
semanticscholar   +1 more source

The fat and the bad: Mature adipocytes, key actors in tumor progression and resistance

OncoTarget, 2017
Growing evidence has raised the important roles of adipocytes as an active player in the tumor microenvironment. In many tumors adipocytes are in close contact with cancer cells.
M. Duong, A. Geneste, F. Fallone, Xia Li, C. Dumontet, C. Muller   +5 more
semanticscholar   +1 more source

Lipid and glucose metabolism in white adipocytes: pathways, dysfunction and therapeutics

Nature Reviews Endocrinology, 2021
Pauline Morigny, J. Boucher, P. Arner, D. Langin   +3 more
semanticscholar   +1 more source

Exosomes released by hepatocarcinoma cells endow adipocytes with tumor-promoting properties

Journal of Hematology & Oncology, 2018
BackgroundThe initiation and progression of hepatocellular carcinoma (HCC) are largely dependent on its local microenvironment. Adipocytes are an important component of hepatic microenvironment in nonalcoholic fatty liver disease (NAFLD), which is a ...
Shihua Wang, Meiqian Xu, Xiaoxia Li, Xiaodong Su, Xian Xiao, A. Keating, R. Zhao   +6 more
semanticscholar   +1 more source

Adipocyte-Mediated Electrophysiological Remodeling of PKP-2 Mutant Human Pluripotent Stem Cell-Derived Cardiomyocytes

Biomedicines
Background: Arrhythmogenic cardiomyopathy (ACM) is a genetic disorder responsible for nearly a quarter of sports-related sudden cardiac deaths. ACM cases caused by mutations in desmosome proteins lead to right ventricular enlargement, the loss of ...
Justin Morrissette-McAlmon, Christianne J. Chua, Alexander Arking, Stanley Chun Ming Wu, Roald Teuben, Elaine Zhelan Chen, Leslie Tung, Kenneth R. Boheler   +7 more
doaj   +1 more source

Expression, activity, and localization of hormone-sensitive lipase in rat mammary gland during pregnancy and lactation

Journal of Lipid Research, 2005
We examined the presence of hormone-sensitive lipase (HSL) in mammary glands of virgin, pregnant (12, 20, and 21 days), and lactating (1 and 4 days postpartum) rats.
Antonia Martín-Hidalgo, Lydia Huerta, Nieves Álvarez, Gemma Alegría, María del Val Toledo, Emilio Herrera   +5 more
doaj   +1 more source

Increased lipolysis in transgenic animals overexpressing the epithelial fatty acid binding protein in adipose cells

Journal of Lipid Research, 2002
Fatty acid binding proteins (FAB2222251) are low-molecular-mass, soluble, intracellular lipid carriers. Previous studies on adipocytes from adipocyte fatty acid binding protein (A-FABP)-deficient mice have revealed that both basal and isoproterenol ...
Ann Vogel Hertzel, Assumpta Bennaars-Eiden, David A. Bernlohr   +2 more
doaj   +1 more source