Results 31 to 40 of about 158,878 (217)

Screening of Reference Genes for RT-qPCR in Chicken Adipose Tissue and Adipocytes

Frontiers in Physiology, 2021
Reverse transcription quantitative real-time PCR is the most commonly used method to detect gene expression levels. In experiments, it is often necessary to correct and standardize the expression level of target genes with reference genes.
Wei Na, Wei Na, Wei Na, Wei Na, Yuxiang Wang, Yuxiang Wang, Yuxiang Wang, Pengfei Gong, Pengfei Gong, Pengfei Gong, Xinyang Zhang, Xinyang Zhang, Xinyang Zhang, Ke Zhang, Ke Zhang, Ke Zhang, Hui Zhang, Hui Zhang, Hui Zhang, Ning Wang, Ning Wang, Ning Wang, Hui Li, Hui Li, Hui Li   +24 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Anti-Inflammatory and Cytotoxicity Effects of Cudrania tricuspidata Fruits Vinegar in a Co-Culture System with RAW264.7 Macrophages and 3T3-L1 Adipocytes

Foods, 2020
Vinegar has been found to have in vitro improvement effect on inflammatory biomarkers, and clinically used to improve inflammation and obesity-related diseases.
Jun-Hui Choi, Se-Eun Park, Soo-Hwan Yeo, Seung Kim   +3 more
doaj   +1 more source

Adipocytes-Derived Extracellular Vesicle-miR-26b Promotes Apoptosis of Cumulus Cells and Induces Polycystic Ovary Syndrome

Frontiers in Endocrinology, 2022
BackgroundPolycystic ovary syndrome (PCOS) is a refractory reproductive disease and also a kind of endocrine and metabolic disease. Adipocyte cells can produce a mass of extracellular vesicles and orchestrate the status of other types cells.
Guannan Zhou, Guannan Zhou, Yuanyuan Gu, Yuanyuan Gu, Fangyue Zhou, Fangyue Zhou, Hongdao Zhang, Menglei Zhang, Menglei Zhang, Ganrong Zhang, Ganrong Zhang, Ligang Wu, Keqin Hua, Keqin Hua, Jingxin Ding, Jingxin Ding   +15 more
doaj   +1 more source

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

Intrinsic Properties of Brown and White Adipocytes Have Differential Effects on Macrophage Inflammatory Responses

Mediators of Inflammation, 2017
Obesity is marked by chronic, low-grade inflammation. Here, we examined whether intrinsic differences between white and brown adipocytes influence the inflammatory status of macrophages.
Louisa Dowal, Pooja Parameswaran, Sarah Phat, Syamala Akella, Ishita Deb Majumdar, Jyoti Ranjan, Chahan Shah, Saie Mogre, Kalyani Guntur, Khampaseuth Thapa, Stephane Gesta, Vivek K. Vishnudas, Niven R. Narain, Rangaprasad Sarangarajan   +13 more
doaj   +1 more source

HOXA5-miR-574-5p axis promotes adipogenesis and alleviates insulin resistance

Molecular Therapy: Nucleic Acids, 2022
Differentiation of preadipocytes into functional adipocytes could be a major target for repressing obesity-induced insulin resistance (IR). However, the molecular mechanisms involved in adipogenesis and the development of IR are unclear.
Yuying Li, Jiayin Li, Haibo Yu, Yanxia Liu, Haixu Song, Xiaoxiang Tian, Dan Liu, Chenghui Yan, Yaling Han   +8 more
doaj   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Thy-1 Deficiency Augments Bone Loss in Obesity by Affecting Bone Formation and Resorption

Frontiers in Cell and Developmental Biology, 2018
Healthy bone remodeling results from a balanced bone formation and bone resorption realized by bone-forming osteoblasts and bone-resorbing osteoclasts, respectively.
Ann-Kristin Picke, Ann-Kristin Picke, Graeme M. Campbell, Felix N. Schmidt, Björn Busse, Martina Rauner, Jan C. Simon, Ulf Anderegg, Lorenz C. Hofbauer, Anja Saalbach   +9 more
doaj   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source