Results 21 to 30 of about 267,086 (349)
Reduced intestinal lipid absorption improves glucose metabolism in aged G2-Terc knockout mice
BMC Biology, 2023 Background Biological aging is an important factor leading to the development of pathologies associated with metabolic dysregulation, including type 2 diabetes, cancer, cardiovascular and neurodegenerative diseases.
Xue Liu +10 more
doaj +1 more source
Active integrins regulate white adipose tissue insulin sensitivity and brown fat thermogenesis
Molecular Metabolism, 2021 Objective: Reorganization of the extracellular matrix is a prerequisite for healthy adipose tissue expansion, whereas fibrosis is a key feature of adipose dysfunction and inflammation.
Francisco Javier Ruiz-Ojeda +15 more
doaj +1 more source
PAT2 regulates vATPase assembly and lysosomal acidification in brown adipocytes
Molecular Metabolism, 2022 Objective: Brown adipocytes play a key role in maintaining body temperature as well as glucose and lipid homeostasis. However, brown adipocytes need to adapt their thermogenic activity and substrate utilization to changes in nutrient availability ...
Jiefu Wang +9 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2022 Abdominal obesity associates with cardiometabolic disease and an accumulation of lipids in the visceral adipose depot, whereas lipid accumulation in the subcutaneous depot is more benign.
Neha Mathur +12 more
doaj +1 more source
Role of SUMO-Specific Protease 2 in Leptin-Induced Fatty Acid Metabolism in White Adipocytes [PDF]
Diabetes & Metabolism Journal, 2023 Background Leptin is a 16-kDa fat-derived hormone with a primary role in controlling adipose tissue levels. Leptin increases fatty acid oxidation (FAO) acutely through adenosine monophosphate-activated protein kinase (AMPK) and on delay through the SUMO ...
Praise Chanmee Kim +3 more
doaj +1 more source
The International Journal of Biochemistry & Cell Biology, 2010 Lipolysis in adipocytes, the hydrolysis of triacylglycerol (TAG) to release fatty acids (FAs) and glycerol for use by other organs, is a unique function of white adipose tissue. Lipolysis in adipocytes occurs at the surface of cytosolic lipid droplets, which have recently gained much attention as dynamic organelles integral to lipid metabolism ...
Maryam, Ahmadian +2 more
openaire +2 more sources
Scientific Reports, 2021 The NAD+-dependent deacetylase SIRT1 controls key metabolic functions by deacetylating target proteins and strategies that promote SIRT1 function such as SIRT1 overexpression or NAD+ boosters alleviate metabolic complications. We previously reported that
Y. Majeed +15 more
semanticscholar +1 more source
Integrin αV Mediates the Effects of Irisin on Human Mature Adipocytes
Obesity Facts, 2022 Introdution and Aims: The myokine irisin is critical to modulating adipocytes thermogenesis and influence whole-body metabolism. However, whether there is difference in the effects of irisin on adipocytes derived from different depots remains unknown ...
Tingting Fu +6 more
doaj +1 more source
snRNA-seq reveals a subpopulation of adipocytes that regulates thermogenesis
Nature, 2020 Adipose tissue is usually classified on the basis of its function as white, brown or beige (brite) 1 . It is an important regulator of systemic metabolism, as shown by the fact that dysfunctional adipose tissue in obesity leads to a variety of secondary ...
Wenfei Sun +17 more
semanticscholar +1 more source
Insulin action in adipocytes, adipose remodeling, and systemic effects
Cell Metabolism, 2021 On this 100th anniversary of the discovery of insulin, we recognize the critical role that adipocytes, which are exquisitely responsive to insulin, have played in determining the mechanisms for insulin action at the cellular level.
A. Santoro, T. McGraw, B. Kahn
semanticscholar +1 more source