Results 41 to 50 of about 267,086 (349)

Lipopolysaccharide, high glucose and saturated fatty acids induce endoplasmic reticulum stress in cultured primary human adipocytes : salicylate alleviates this stress [PDF]

, 2010
Recent findings indicate that endoplasmic reticulum (ER) stress is significantly increased in adipose tissue of obese human subjects and is critical to the initiation and integration of pathways of inflammation and insulin action.
Saif Alhusaini, Harte, A., McGee, K., Gyanendra Tripathi, Kumar, Sudhesh, Tripathi, Gyanendra, Sudhesh Kumar, Alhusaini, S., McTernan, P. G., Harte, A. L., McTernan, P., Bruno Schisano, Philip McTernan, Schisano, B., McGee, K. C., Kumar, S., Alison Harte, Tripathi, G., Kirsty McGee   +18 more
core   +1 more source

Tunicamycin-induced Endoplasmic Reticulum stress mediates mitochondrial dysfunction in human adipocytes [PDF]

, 2020
Context: Dysfunctional ER and mitochondria are known to contribute to the pathology of metabolic disease. This damage may occur, in part, as a consequence of ER-mitochondria cross-talk in conditions of nutrient excess such as obesity.
Randeva, H, Murphy, AM, Jackisch, Laura, McTernan, Philip G, Tripathi, G, Kumar, S, Jackisch, L, Murphy, Alice M, Randeva, Harpal, Kumar, Sudhesh, Tripathi, Gyanendra, McTernan, PG   +11 more
core   +1 more source

RIP140 represses the “Brown-in-White” adipocyte program including a futile cycle of triacyclglycerol breakdown and synthesis [PDF]

, 2014
Receptor-interacting protein 140 (RIP140) is a corepressor of nuclear receptors that is highly expressed in adipose tissues. We investigated the role of RIP140 in conditionally immortal preadipocyte cell lines prepared from white or brown fat depots.
Edward Curry, Curry, Edward, Myrsini Kaforou, Cinti, S, Cinti, Saverio, Saverio Cinti, Lemonia Chatzeli, Parker, MG, Kiskinis, E, Kiskinis, Evangelos, Kaforou, M, Frontini, A, Chatzeli, Lemonia, Montana, G, Chatzeli, L, Curry, E, Kaforou, Myrsini, Evangelos Kiskinis, Montana, Giovanni, Christian, Mark, Giovanni Montana, Frontini, Andrea, Mark Christian, Parker, Malcolm G., Christian, M, Malcolm G. Parker   +25 more
core   +1 more source

Characterization of human bone marrow derived mesenchymal stem cells as a model for in vitro adipocytes studies [PDF]

, 2013
Overweight and obesity are major problems of public health in many countries worldwide. Overweight can cause severe diseases such as type II diabetes mellitus, hypertension, stroke, heart failure and several types of cancer.
Hirzel, Estelle
core   +1 more source

Implication of adipocytes from subcutaneous adipose tissue and fatty [PDF]

, 2022
The role of subcutaneous adipose tissue adipocytes and the effects of fatty acids on carrageenan-induced skin inflammation in gilthead seabream (Sparus aurata) were studied. Fish were injected intramuscularly with phosphate-buffered saline (control) or λ-
Carlos Campos-Sánchez, Jose, Broughton, Richard, Gonzalez-Silvera, Daniel, Guardiola, Francisco A, Betancor, Mónica B, Gong, Xu, Ángeles, María   +6 more
core   +1 more source

Extracellular calcium modulates brown adipocyte differentiation and identity

Scientific Reports, 2017
Brown adipocytes are important in regulating non-shivering thermogenesis, whole body glucose and lipid homeostasis. Increasing evidence supports an important role of metabolites as well as macro- and micronutrients in brown adipocyte differentiation and ...
Ines Pramme-Steinwachs, Martin Jastroch, Siegfried Ussar   +2 more
doaj   +1 more source

Transferrin Receptor Functionally Marks Thermogenic Adipocytes

Frontiers in Cell and Developmental Biology, 2020
BackgroundThermogenic adipocytes, including beige and brown adipocytes, are critical for thermogenesis and energy homeostasis. Identification of functional cell surface markers of thermogenic adipocytes is of significance for potential application in ...
Jin Qiu, Zhiyin Zhang, Sainan Wang, Yanru Chen, Caizhi Liu, Sainan Xu, Dongmei Wang, Junlei Su, Mengshan Ni, Jian Yu, Xiangdi Cui, Lu Ma, Tianhui Hu, Yepeng Hu, Xuejiang Gu, Xinran Ma, Xinran Ma, Jiqiu Wang, Lingyan Xu   +18 more
doaj   +1 more source

Dydrogesterone and norethisterone regulate expression of lipoprotein lipase and hormones-sensitive lipase in human subcutaneous abdominal adipocytes [PDF]

, 2007
Aim: In premenopausal women, hyper-androgenicity is associated with central obesity and an increased cardiovascular risk. We investigated the effects of dydrogesterone (DYD)(a non-androgenic progestogen) and norethisterone (NET)(an androgenic progestogen)
Sturdee, D. W., D. W. Sturdee, Palin, SL, Barnett, Anthony, S. L. Palin, K. C. McGee, Kumar, Sudhesh, McTernan, PG, McTernan, P. G., Barnett, A. H., Sturdee, David, Kumar, S, A. H. Barnett, McGee, K. C., McGee, KC, P. G. McTernan, Palin, S. L., S. Kumar   +17 more
core   +1 more source

Effect of metformin on transcriptome and adipokinome of adipocytes of local fat deposts of patients with ischemic heart disease

Ожирение и метаболизм, 2023
BACKGROUND: The information available to date on the effect of metformin on the transcriptome and secretory capacity of adipocytes in human adipose tissue (AT) is scarce and contradictory.
Yu. A. Dyleva, O. V. Gruzdeva, E. V. Belik, D. A. Borodkina, M. Yu. Sinitskiy, S. V. Ivanov, O. L. Barbarash   +6 more
doaj   +1 more source

Overexpression of DGAT2 Regulates the Differentiation of Bovine Preadipocytes

Animals, 2023
Triacylglycerols (TAGs) are a major component of intramuscular fat. Diacylglycerol O-acyltransferase 2(DGAT2) expression determines the rate of TAG synthesis.
Pan-Pan Guo, Xin Jin, Jun-Fang Zhang, Qiang Li, Chang-Guo Yan, Xiang-Zi Li   +5 more
doaj   +1 more source