Results 51 to 60 of about 194,972 (197)
NRAC controls CD36-mediated fatty acid uptake in adipocytes and lipid clearance in vivo
The EMBO JournalAdipose tissue is a central organiser of systemic lipid homeostasis and a pharmacological target in obesity, orchestrating cellular responses to environmental cues.
Inderjeet Singh +36 more
doaj +1 more source
Sulfated galactan from Acanthophora muscoides inhibits adipogenesis via regulating adipogenic transcription factors and AMPK in 3T3-L1 cells [PDF]
Brazilian Journal of BiologyObesity is a global public health issue, closely linked to cardiovascular disease and type 2 diabetes. Pharmacological interventions for weight loss are one option for treating obesity; however, these drugs often come with side effects or limited ...
A. V. L. Silva +5 more
doaj +1 more source
Antioxidants, 2020 This review summarizes data from several laboratories that have demonstrated a role of the Na/K-ATPase, specifically its α1 subunit, in the generation of reactive oxygen species (ROS) via the negative regulator of Src.
Zi-jian Xie +7 more
doaj +1 more source
Hypoxia-driven metabolic reprogramming of adipocytes fuels cancer cell proliferation
Frontiers in Endocrinology, 2022 ObjectiveObesity increases the risk of certain cancers, especially tumours that reside close to adipose tissue (breast and ovarian metastasis in the omentum).
R. Aird +8 more
doaj +1 more source
Tunicamycin-induced ER stress mediates mitochondrial dysfunction in human adipocytes
, 2014 The pathogenesis of obesity and T2DM mediates mitochondrial dysfunction which, in part, may arise as a consequence of endoplasmic reticulum (ER) stress. However, the potential impact of ER stress on mitochondria dysfunction is unclear.
Randeva, H +5 more
core +1 more source
CIRCADIAN RHYTHMICITY IN MURINE PRE-ADIPOCYTE AND ADIPOCYTE CELLS
Chronobiology International, 2009 Adipose tissue is central to metabolic homeostasis, signaling in part through the secretion of molecules termed adipokines. Circadian rhythms play an important role in adipose physiology, with plasma adipokine concentration and approximately 20 % of the murine adipose transcriptome undergoing 24 h variation. However, due to the heterogeneity of adipose
Otway, DT, Frost, G, Johnston, JD
openaire +5 more sources
BiologyThe growing obesity epidemic necessitates increased research on adipocyte and adipose tissue function and disease mechanisms that progress obesity. Historically, adipocytes were viewed simply as storage for excess energy. However, recent studies have demonstrated that adipocytes play a critical role in whole-body homeostasis, are involved in cell ...
Sean P. Blade +4 more
openaire +3 more sources
Rôle des adipocytes péri-tumoraux dans la progression tumorale mammaire [PDF]
, 2011 De nombreux arguments suggèrent que la progression tumorale est non seulement dépendante des cellules cancéreuses mais aussi des cellules normales qui entourent la tumeur.
Bochet, Ludivine
core
Oral Protein Therapy for the Future - Transport of Glycolipid-Modified Proteins: Vision or Fiction? [PDF]
, 2010 The reliable and early diagnosis of common complex multifactorial diseases depends on the individual determination of all (or as many as possible) polymorphisms of each susceptibility gene together with amount and type of the corresponding gene products ...
Mueller, Guenter, Günter Müller
core +1 more source
BiomedicinesBackground: Arrhythmogenic cardiomyopathy (ACM) is a genetic disorder responsible for nearly a quarter of sports-related sudden cardiac deaths. ACM cases caused by mutations in desmosome proteins lead to right ventricular enlargement, the loss of ...
Justin Morrissette-McAlmon +7 more
doaj +1 more source