Results 71 to 80 of about 267,086 (349)

Synthesis of Ziziphus spina-christi (Jujube) Root Methanol Extract Loaded Functionalized Silver Nanoparticle (ZS-Ag-NPs); Physiochemical Characterization and Effect of ZS-Ag-NPs on Adipocyte Maturation, Adipokine and Vascular Smooth Muscle Cell Interaction

Nanomaterials, 2021
In this research, a simple, green approach was employed to synthesize silver nanoparticles with the aid of Ziziphus spina-christi (L.) methanol root extract, which can act as a reducing, capping agent to treat obesity and inflammation. Globally, Ziziphus
Abu ElGasim Ahmed Yagoub, Ghedeir Muslem Alshammari, Pandurangan Subash-Babu, Mohammed Awad alkareem Mohammed, Mohammed Abdo Yahya, Aesha Ibrahim Alhosain   +5 more
doaj   +1 more source

Role of adipocyte-derived lipoprotein lipase in adipocyte hypertrophy [PDF]

Nutrition & Metabolism, 2007
A major portion of available fatty acids for adipocyte uptake is derived from lipoprotein lipase (LPL)-mediated hydrolysis of circulating lipoprotein particles. In vivo studies aimed at identifying the precise role of adipocyte-derived LPL in fat storage function of adipose tissue have been unable to provide conclusive evidence due to compensatory ...
Orlando Robert A, Gonzales Amanda M
openaire   +3 more sources

A PRDM16-driven metabolic signal from adipocytes regulates precursor cell fate

Cell Metabolism, 2019
Summary The precursor cells for metabolically beneficial beige adipocytes can alternatively become fibrogenic and contribute to adipose fibrosis. This adipogenic versus fibrogenic fate decision is poorly understood. Cold exposure or β3-adrenergic agonist
Wenshan Wang, Jeff Ishibashi, Sophie Trefely, Sophie Trefely, Mengle Shao, Alexis Cowan, Alexander Sakers, Hee-Woong Lim, Sean O’Connor, Mary T. Doan, P. Cohen, Joseph A. Baur, M. King, R. Veech, Kyoung-Jae Won, Joshua D. Rabinowitz, N. Snyder, Rana K. Gupta, P. Seale   +18 more
semanticscholar   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Bone marrow adipocytes promote the regeneration of stem cells and hematopoiesis by secreting SCF

Nature Cell Biology, 2017
Endothelial cells and leptin receptor+ (LepR+) stromal cells are critical sources of haematopoietic stem cell (HSC) niche factors, including stem cell factor (SCF), in bone marrow.
B. Zhou, Hua Yu, R. Yue, Zhiyu Zhao, J. Rios, O. Naveiras, S. Morrison   +6 more
semanticscholar   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Intrinsic Properties of Brown and White Adipocytes Have Differential Effects on Macrophage Inflammatory Responses

Mediators of Inflammation, 2017
Obesity is marked by chronic, low-grade inflammation. Here, we examined whether intrinsic differences between white and brown adipocytes influence the inflammatory status of macrophages.
Louisa Dowal, Pooja Parameswaran, Sarah Phat, Syamala Akella, Ishita Deb Majumdar, Jyoti Ranjan, Chahan Shah, Saie Mogre, Kalyani Guntur, Khampaseuth Thapa, Stephane Gesta, Vivek K. Vishnudas, Niven R. Narain, Rangaprasad Sarangarajan   +13 more
doaj   +1 more source

INSULIN AND LEPTIN: DISPUTABLE AND UNSOLVED QUESTIONS OF THEIR INTERACTION

Атеросклероз, 2019
Leptin and its receptor are widely distributed mainly in white adipose tissue. Serum leptin concentration correlates with body mass index, and its levels decrease with fasting.
E. V. Belik, O. V. Gruzdeva, E. I. Palicheva   +2 more
doaj   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Mammary adipocytes stimulate breast cancer invasion through metabolic remodeling of tumor cells.

JCI Insight, 2017
In breast cancer, a key feature of peritumoral adipocytes is their loss of lipid content observed both in vitro and in human tumors. The free fatty acids (FFAs), released by adipocytes after lipolysis induced by tumor secretions, are transferred and ...
Y. Wang, C. Attané, D. Milhas, B. Dirat, S. Dauvillier, Adrien Guérard, J. Gilhodes, I. Lazar, N. Alet, Victor Laurent, S. Le Gonidec, D. Biard, C. Hervé, F. Bost, G. Ren, F. Bono, G. Escourrou, M. Prentki, Laurence Nieto, P. Valet, C. Muller   +20 more
semanticscholar   +1 more source